Symptomatology and Neuropsychological Functioning in Cannabis Using Subjects at Ultra-High Risk for Developing Psychosis and Healthy Controls

Korver, Nikie; Nieman, Dorien H.; Becker, Hiske E.; Fliert, J.R. van de; Dingemans, Peter; Haan, Lieuwe de; Spiering, Menno; Schmitz, Nicole; Linszen, Don

doi:10.3109/00048670903487118

Cited by 51 publications

(56 citation statements)

References 23 publications

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“…Executive function impairments including working memory (WM) [39][40][41][42][43][44][45][46][47], spatial memory and verbal fluency deficits [48][49][50][51][52][53][54][55], and reward and salience processing anomalies [56][57][58][59] are pronounced cognitive features found in schizophrenia. However, the relation of physiological and clinical variables (positive, negative symptoms) is complicated by the multidimensional nature of psychotic symptoms.…”

Section: Neuroimaging Findings In Psychosismentioning

confidence: 99%

Neuroimaging and Resilience Factors - Staging of the At-risk Mental State?

Smieskova¹,

Fusar‐Poli²,

Riecher‐Rössler³

et al. 2012

CPD

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Over the past decade, vulnerability-and psychosis-associated structural and functional brain abnormalities in a population at high clinical risk to develop psychosis were intensively studied. We reviewed the results from studies comparing at-risk mental state (ARMS) individuals with and without subsequent transition to psychosis. Additionally, we introduced a new concept of splitting ARMS population according to the duration of the psychosis risk syndrome and their probability to develop psychosis. Studying the ARMS individuals still vulnerable to psychosis but with lower risk to transit can disclose the possible protective -resilience factors or characteristics. Resilience, understood as ability to recover from change, can be thus applied in the early intervention for high clinical risk for psychosis individuals.

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Section: Neuroimaging Findings In Psychosismentioning

confidence: 99%

Neuroimaging and Resilience Factors - Staging of the At-risk Mental State?

Smieskova¹,

Fusar‐Poli²,

Riecher‐Rössler³

et al. 2012

CPD

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“…Third, little is known about the change in substance use over time in this population. Fourth, in studies examining the substance use-transition to psychosis link, some recorded patterns of cannabis use only (Korver et al 2010) whereas other studies grouped the use of any substance into one variable (Cannon et al 2008; Thompson et al 2011). Fifth, studies that reported on smaller sample sizes may be underpowered to detect an effect of substance use on transition to psychosis.…”

Section: Introductionmentioning

confidence: 99%

“…Fifth, studies that reported on smaller sample sizes may be underpowered to detect an effect of substance use on transition to psychosis. Further details on cannabis use in particular also deserve further evaluation as there are some results suggesting that cannabis use may be related to severity of attenuated psychotic symptoms (Corcoran et al 2008;Korver et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Substance use in individuals at clinical high risk of psychosis

et al. 2015

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Background. A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between substance use and later transition to psychosis in CHR individuals are mixed.Method. At baseline and 6-and 12-month follow-ups, 735 CHR and 278 control participants completed the Alcohol and Drug Use Scale and a cannabis use questionnaire. The longitudinal trajectory of substance use was evaluated with linear mixed models.Results. CHR participants endorsed significantly higher cannabis and tobacco use severity, and lower alcohol use severity, at baseline and over a 1-year period compared with controls. CHR youth had higher lifetime prevalence and frequency of cannabis, and were significantly younger upon first use, and were more likely to use alone and during the day. Baseline substance use did not differentiate participants who later transitioned to psychosis (n = 90) from those who did not transition (n = 272). Controls had lower tobacco use than CHR participants with a prodromal progression clinical outcome and lower cannabis use than those with a psychotic clinical outcome at the 2-year assessment.Conclusions. In CHR individuals cannabis and tobacco use is higher than in controls and this pattern persists across 1 year. Evaluation of clinical outcome may provide additional information on the longitudinal impact of substance use that cannot be detected through evaluation of transition/non-transition to psychosis alone.

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“…9,10 Recent reviews suggest that marijuana is a partial causal factor. 11 The association between marijuana use and the onset of psychosis is stronger for people with a predisposition for psychotic disorders. Onset of use before the age of 16 has a much stronger effect than if the cannabis use started at a later age.…”

mentioning

confidence: 99%

“…Onset of use before the age of 16 has a much stronger effect than if the cannabis use started at a later age. 11 It can be concluded that early marijuana use is a risk modifying factor for psychosis related outcomes. 9 There is an emerging body of evidence that suggests that the early stage of schizophrenia might provide an opportunity for interventions, even very simple ones that may help to prevent the development of full blown schizophrenia.…”

mentioning

confidence: 99%