Symptomatic hyponatremia after ChAdOx1 nCoV-19 coronavirus disease-19 vaccination

Chienwichai, Kittiphan; Sriinkua, Phanuphong; Chang, Arunchai

doi:10.5414/cn110906

Cited by 6 publications

(5 citation statements)

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“…The concurrent serum sodium level was 111 mEq/L, suggesting that hyponatremia, possibly caused by the immunization, may have contributed to the seizure 44 . Developing hyponatremia after Oxford/AstraZeneca COVID‐19 vaccination has also rarely been reported 51 …”

Section: Discussionmentioning

confidence: 99%

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Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Rafati,

Jameie,

Amanollahi

et al. 2023

Journal of Medical Virology

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Seizure aggravation following coronavirus disease 2019 (COVID‐19) vaccines is a major cause behind vaccine hesitancy among persons with epilepsy (PwE), resulting in lower immunization rates. We systematically reviewed seizure‐activity‐related events in PwE following COVID‐19 vaccination. We systematically searched PubMed, Web of Science, Scopus, and Cochrane Library, until January 31, 2023, and included articles reporting seizure activity‐related events in PwE receiving COVID‐19 vaccination. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses were followed. The protocol was registered with PROSPERO (CRD42022312475). Outcomes included pooled incidence proportions of (a) increased seizure frequency, (b) status epilepticus (SE), and (c) change in seizure type. Of the 2207 studies, 16 entered the meta‐analysis. The pooled incidence proportion of increased seizure frequency (16 studies‐3245 PwE) was 5% (95% CI: 3%−7%, I2 = 52%). Regarding increased seizure frequency, no significant difference was observed between mRNA and viral vector (OR: 1.11, 95% CI: 0.49−2.52, I2 = 0%), and between mRNA and inactivated virus (OR: 1.60, 95% CI: 0.27−9.37; I2 = 0%). The pooled incidence proportion of SE (15 studies‐2387 PwE) was 0.08% (95% CI: 0.02%−0.33%, I2 = 0%). Ultimately, the pooled incidence proportion of change in seizure type (7 studies‐1172 PwE) was 1% (95% CI: 1%−2%, I2 = 0%). The meta‐analysis revealed post‐COVID‐19‐vaccination increased seizure frequency in 5% of PwE, with no difference between mRNA and viral vector or inactivated virus vaccines. Furthermore, we found 0.08% and 1% incidence proportions for postvaccination SE and change in seizure type, respectively. While noteworthy, these values are far less than reports for COVID‐19 infection, emphasizing vaccination importance in preventing COVID‐19 consequences in PwE.

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Section: Discussionmentioning

confidence: 99%

“…44 Developing hyponatremia after Oxford/AstraZeneca COVID-19 vaccination has also rarely been reported. 51…”

Section: Other Possible Related Factorsmentioning

confidence: 99%

Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Rafati,

Jameie,

Amanollahi

et al. 2023

Journal of Medical Virology

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“…Not only SARS-CoV-2 itself but also specific vaccines against it could also potentially induce acute cytokine release [125] thus causing endocrine dysfunction [126] . Rare and isolated case reports raise the possibility of SIADH [127] , [128] or central AVP deficiency after vaccination- one case developing AVP deficiency one week after BNT162b2mRNA COVID-19 vaccine (BioNTech/Pfizer) administration, with infundibulo-neurohypophysitis on MRI images [129] .…”

Section: Pituitary Pathology In the Context Of Covid-19mentioning

confidence: 99%

Pituitary and SARS CoV-2: An unremitting conundrum

Căpățînă

Poiană

Fleseriu

2023

Best Practice & Research Clinical Endocrinology & Metab

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“…In the thyroid gland, the most common disorder was subacute thyroiditis, 5 followed by autoimmune thyroid disease, newly diagnosed or relapsed Graves’ disease, 6 in addition to cases of painless thyroiditis, 14 totaling more than 100 cases. Severe hyponatremia has been reported after immunization with COVID-19 vaccine, 15 , 16 which was later confirmed to be syndrome of inappropriate antidiuresis. 16 Murvelashvili N reported a case of pituitary inflammation following immunization with the mRNA-1273 SARS-CoV-2 vaccine, which is the first reported case of hypopituitarism possibly associated with immunization against COVID-19.…”

Section: Discussionmentioning

confidence: 90%

Hypophysitis after COVID-19 vaccination in a patient with Rathke’s cleft cyst: A case report

Yu,

Zhou,

et al. 2024

Human Vaccines & Immunotherapeutics

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With the widespread vaccination of COVID-19 vaccine, a few cases have been reported that COVID-19 vaccine may cause endocrine disorders. A 59-y-old man presented with a loss of appetite after the first COVID-19 vaccination, which resolved spontaneously after 3 d. After the second COVID-19 vaccination, the symptoms including the loss of appetite, nausea, and vomiting reappeared and worsened along with loss of vision. He was found to have severe hyponatremia, and further investigations revealed secondary adrenal insufficiency, secondary hypothyroidism and Rathke’s cleft cyst. The patient responded well to glucocorticoid and levothyroxine supplementation, and at 1-y follow-up the patient developed hypogonadism. We hypothesize that hypophysitis is probably induced by COVID-19 vaccine and report the rare but serious adverse reactions for early recognition and intervention.

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Symptomatic hyponatremia after ChAdOx1 nCoV-19 coronavirus disease-19 vaccination

Cited by 6 publications

References 0 publications

Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Pituitary and SARS CoV-2: An unremitting conundrum

Hypophysitis after COVID-19 vaccination in a patient with Rathke’s cleft cyst: A case report

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