Symplocos cochinchinensis enhances insulin sensitivity via the down regulation of lipogenesis and insulin resistance in high energy diet rat model

Antu, Kalathookunnel Antony; Riya, Mariam Philip; Nair, Anupama; Mishra, Arvind; Srivastava, Arvind K.; Raghu, Kozhiparambil Gopalan

doi:10.1016/j.jep.2016.09.050

Cited by 18 publications

(6 citation statements)

References 48 publications

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“…The oral administration of S. cochinchinesis extract at 250 and 500 mg kg −1 .day −1 significantly reduced the plasma glucose level in diabetic induced rats with insulin resistant on day 20. 39 Simultaneously, it was observed that the plasma insulin level and homeostatic model assessment score on insulin resistance (HOM-IR) in treatment group were significantly lower as compared to control group, suggesting improved sensitivity of the cells towards endogenous insulin. 39 Similarly, ethanolic extract of Helicterus angustifolia root was also found to have antidiabetic potential.…”

Section: Herbal Remedy In Diabetesmentioning

confidence: 96%

“… 39 Simultaneously, it was observed that the plasma insulin level and homeostatic model assessment score on insulin resistance (HOM-IR) in treatment group were significantly lower as compared to control group, suggesting improved sensitivity of the cells towards endogenous insulin. 39 Similarly, ethanolic extract of Helicterus angustifolia root was also found to have antidiabetic potential. A 200 and 400 mg/kg/day dose for a period of 28 days in STZ-induced diabetic rats resulted in significant reduction in blood glucose, plasma insulin level and HOMA-IR in treatment group as compared to control group.…”

Section: Herbal Remedy In Diabetesmentioning

confidence: 96%

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An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

345

192

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Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for medicinal purposes. Medicinal use of herbal medicine in the treatment and prevention of diseases including diabetes has a long history compared to conventional medicine. Diabetes is one of the major public health concerns over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazard; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes. There are various approaches to treat and prevent diabetes as well as its secondary complications, one of it is herbal medicines. However, the selection of herbs might depends on several factors, which include the stage of progression of diabetes, types of comorbidities that the patients are having, availability, affordability as well as the safety profile of the herbs. This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder – diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.

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Section: Herbal Remedy In Diabetesmentioning

confidence: 96%

Section: Herbal Remedy In Diabetesmentioning

confidence: 96%

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Choudhury

Pandey

Hua

et al. 2018

Journal of Traditional and Complementary Medicine

345

192

View full text Add to dashboard Cite

show abstract

“…Hepatic gene expression and protein profiles were analyzed after administration of the ethanol extract. The results indicated that S. cochinchinensis ethanol extract decreased the expression of SCD-1, SREBP-1c, and FAS to modulate lipid accumulation and attenuate hepatic insulin resistance [ 25 ]. Another traditional herbal medicine for obesity and diabetes—the root of Salacia oblonga , belonging to the family Celastraceae—exhibited a regulation effect on fructose-induced fatty liver in rats.…”

Section: Effects Of Natural Products On Fructose-induced Nafldmentioning

confidence: 99%

Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD)

Chen

Wang

Li³

et al. 2017

Nutrients

133

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As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is related to several pathological processes, including: (1) augmenting lipogenesis; (2) leading to mitochondrial dysfunction; (3) stimulating the activation of inflammatory pathways; and (4) causing insulin resistance. Cellular signaling research indicated that partial factors play significant roles in fructose-induced NAFLD, involving liver X receptor (LXR)α, sterol regulatory element binding protein (SREBP)-1/1c, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), peroxisome proliferator–activated receptor α (PPARα), leptin nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), c-Jun amino terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3K) and adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK). Until now, a series of natural products have been reported as regulators of NAFLD in vivo and in vitro. This paper reviews the natural products (e.g., curcumin, resveratrol, and (−)-epicatechin) and their mechanisms of ameliorating fructose-induced NAFLD over the past years. Although, as lead compounds, natural products usually have fewer activities compared with synthesized compounds, it will shed light on studies aiming to discover new drugs for NAFLD.

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“…In recent years, some crude plant extracts have also been reported to reverse overexpression of GLUT2 or suppress its translocation from the cytoplasm to the plasma membrane in cases of MSs or hepatic steatosis. The representative plants include Ficus deltoidea (Moraceae) leaves, 32 Ganoderma lucidum , 33 Psidium guajava leaves, 34 Symplocos cochinchinensis 35 and Urtica dioica (stinging nettle) leaves. 30 …”

Section: Hepatic Glucose Utilization In Normal and Metabolically Distmentioning

confidence: 99%

Natural products, an important resource for discovery of <br />multitarget drugs and functional food for regulation of hepatic glucose metabolism

Li¹,

Yu²,

Wang³

et al. 2018

DDDT

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Imbalanced hepatic glucose homeostasis is one of the critical pathologic events in the development of metabolic syndromes (MSs). Therefore, regulation of imbalanced hepatic glucose homeostasis is important in drug development for MS treatment. In this review, we discuss the major targets that regulate hepatic glucose homeostasis in human physiologic and pathophysiologic processes, involving hepatic glucose uptake, glycolysis and glycogen synthesis, and summarize their changes in MSs. Recent literature suggests the necessity of multitarget drugs in the management of MS disorder for regulation of imbalanced glucose homeostasis in both experimental models and MS patients. Here, we highlight the potential bioactive compounds from natural products with medicinal or health care values, and focus on polypharmacologic and multitarget natural products with effects on various signaling pathways in hepatic glucose metabolism. This review shows the advantage and feasibility of discovering multicompound–multitarget drugs from natural products, and providing a new perspective of ways on drug and functional food development for MSs.

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Symplocos cochinchinensis enhances insulin sensitivity via the down regulation of lipogenesis and insulin resistance in high energy diet rat model

Cited by 18 publications

References 48 publications

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

An update on natural compounds in the remedy of diabetes mellitus: A systematic review

Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD)

Natural products, an important resource for discovery of <br />multitarget drugs and functional food for regulation of hepatic glucose metabolism

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