Sympathomimetics regulate quantal acetylcholine release at neuromuscular junctions through various types of adrenoreceptors

Tsentsevitsky, A. N.; Нуруллин, Л. Ф.; Tyapkina, O. V.; Bukharaeva, É. A.

doi:10.1016/j.mcn.2020.103550

Cited by 9 publications

(16 citation statements)

References 65 publications

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“…In contrast to these data, we observed opposite effects of the adrenergic drugs on spontaneous ACh quantal release at the mouse diaphragm NMJ at a low calcium (Ca 2+ ) concentration [ 30 ]. α1- and α2-adrenoceptor activation by phenylephrine, dexmedetomidine and clonidine decreased the MEPP frequency.…”

Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

“…Previously, we observed the same effects for adrenaline and noradrenaline. The noradrenaline effect was prevented by the β-adrenoceptor blocker propranolol, whereas the adrenaline action was prevented by the α-adrenoceptor antagonist phentolamine [ 30 , 31 ]. The action of specific α1- and α2-adrenoceptor agonists was eliminated by blockers of α1-receptors doxazosin and α2-receptors SKF86466.…”

Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

“…The action of specific α1- and α2-adrenoceptor agonists was eliminated by blockers of α1-receptors doxazosin and α2-receptors SKF86466. β1-receptor activation by xamoterol also decreased the MEPP frequency [ 29 , 30 ]. The described evidences suggests the participation of various adrenoceptor subtypes in spontaneous ACh quanta secretion modulation.…”

Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

“…Specific antagonists SKF and atenolol prevented the effects of activators. In contrast, procaterol, a β2-adrenoceptor agonist, slightly but significantly increased the EPP quantal content [ 30 ]. The oppositely directed action of the different types of adrenergic receptors activators may cause no effect of noradrenaline on the EPP quantal content [ 28 , 31 ].…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

“…In contrast to the observations at frog and soleus muscle NMJ, data obtained demonstrate that the activation of α2-adrenoceptors by dexmedetomidine and β2-adrenoceptors by procaterol increased the ACh quantal secretion asynchrony at mouse diaphragm. These effects were eliminated by α2- and β2-adrenoceptor blockers [ 30 , 31 ].…”

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

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Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva

Khuzakhmetova

Dmitrieva

et al. 2021

IJMS

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Adrenoceptor activators and blockers are widely used clinically for the treatment of cardiovascular and pulmonary disorders. More recently, adrenergic agents have also been used to treat neurodegenerative diseases. Recent studies indicate a location of sympathetic varicosities in close proximity to neuromuscular junctions. The pressing question is whether there could be any effects of endo- or exogenous catecholamines on cholinergic neuromuscular transmission. It was shown that the pharmacological stimulation of adrenoceptors, as well as sympathectomy, can affect both acetylcholine release from motor nerve terminals and the functioning of postsynaptic acetylcholine receptors. In this review, we discuss the recent data regarding the effects of adrenergic drugs on neurotransmission at the neuromuscular junction. The elucidation of the molecular mechanisms by which the clinically relevant adrenomimetics and adrenoblockers regulate quantal acetylcholine release from the presynaptic nerve terminals and postsynaptic sensitivity may help in the design of highly effective and well-tolerated sympathomimetics for treating a number of neurodegenerative diseases accompanied by synaptic defects.

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Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

Section: Activators and Blockers Of Adrenergic Receptors Alter The Spontaneous Achmentioning

confidence: 99%

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

Section: Sympathomimetic Effects On Ach Quantal Release Evoked By the Nerve Stimulusmentioning

confidence: 99%

See 3 more Smart Citations

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva

Khuzakhmetova

Dmitrieva

et al. 2021

IJMS

Self Cite

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Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction

Rudolf,

Kettelhut,

Navegantes

2024

J Muscle Res Cell Motil

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Neuromuscular junctions are the synapses between motor neurons and skeletal muscle fibers, which mediate voluntary muscle movement. Since neuromuscular junctions are also tightly associated with the capping function of terminal Schwann cells, these synapses have been classically regarded as tripartite chemical synapses. Although evidences from sympathetic innervation of neuromuscular junctions was described approximately a century ago, the essential presence and functional relevance of sympathetic contribution to the maintenance and modulation of neuromuscular junctions was demonstrated only recently. These findings shed light on the pathophysiology of different clinical conditions and can optimize surgical and clinical treatment modalities for skeletal muscle disorders.

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The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions

Tsentsevitsky,

Khuzakhmetova,

Bukharaeva

et al. 2023

Neurochem Res

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Sympathomimetics regulate quantal acetylcholine release at neuromuscular junctions through various types of adrenoreceptors

Cited by 9 publications

References 65 publications

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Sympathetic innervation in skeletal muscle and its role at the neuromuscular junction

The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions

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