Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Bukharaeva, É. A.; Khuzakhmetova, Venera; Dmitrieva, S. A.; Tsentsevitsky, A. N.

doi:10.3390/ijms22094611

Cited by 13 publications

(14 citation statements)

References 75 publications

(149 reference statements)

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“…Cholinergic neurotransmission has been implicated in a number of disease states [ 280 , 282 ]. Defects in cholinergic transmission may affect all aspects of cognition and behavior, including cortical and hippocampal processing of information [ 296 ], which was found not only in AD but also in PD, Down syndrome, and ALS [ 297 , 298 ]. In addition, Huntington's disease seems to be related to the decrease of ChAT activity [ 297 , 298 ].…”

Section: Neurotransmitters and Synaptic Function In Neurodegenerative...mentioning

confidence: 99%

Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases

Wei

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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The nervous system is important, because it regulates the physiological function of the body. Neurons are the most basic structural and functional unit of the nervous system. The synapse is an asymmetric structure that is important for neuronal function. The chemical transmission mode of the synapse is realized through neurotransmitters and electrical processes. Based on vesicle transport, the abnormal information transmission process in the synapse can lead to a series of neurorelated diseases. Numerous proteins and complexes that regulate the process of vesicle transport, such as SNARE proteins, Munc18-1, and Synaptotagmin-1, have been identified. Their regulation of synaptic vesicle secretion is complicated and delicate, and their defects can lead to a series of neurodegenerative diseases. This review will discuss the structure and functions of vesicle-based synapses and their roles in neurons. Furthermore, we will analyze neurotransmitter and synaptic functions in neurodegenerative diseases and discuss the potential of using related drugs in their treatment.

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Section: Neurotransmitters and Synaptic Function In Neurodegenerative...mentioning

confidence: 99%

Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases

Wei

Yang

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Hindlimb muscle nerves contain unmyelinated sympathetic postganglionic bers, for example, which account for 40% of all nerve bers in the combined nerve of the lateral gastrocnemius and soleus muscle of the cat [15]. These sympathetic nerve bers appear to be distributed not only in vascular smooth muscle, but also in skeletal muscle bers [16] and neuromuscular junctions [17][18][19]. We identi ed a feedback mechanism between skeletal muscle and sympathetic nerves, in which re ex excitation of the lumbar sympathetic nerves induced by contractions of the hindlimb muscles modulates their contractility [20].…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence for adrenergic receptors on both the skeletal muscle ber itself and on the cholinergic motor nerve terminal [17] and each target have potential to alter the contractility of the muscle ber when activated. The β-receptor-mediated increase in frequency of the miniature endplate potential of dissected hindlimb muscle resulting from sympathetic stimulation was reduced in aged mice (31 months old) compared with young mice (3-4 months old), suggesting decline of sympathetic regulation of cholinergic nerve terminal during aging [21].…”

Section: Introductionmentioning

confidence: 99%

Sympathetic modulation of hindlimb muscle contractility is altered in aged rats

Hotta

Iimura

Watanabe

et al. 2023

Preprint

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It has recently been demonstrated that reflex excitation of muscle sympathetic nerves triggered by muscle contraction contributes to the maintenance of tetanic force (TF) in rat hindlimb muscles. We hypothesized that this feedback mechanism between the contraction of hindlimb muscles and the lumbar sympathetic nerves declines during aging. In this study, we examined the contribution of sympathetic nerves on skeletal muscle contractility in young adult (4–9 months old, n = 11) and aged (32–36 months old, n = 11) male and female rats. The tibial nerve was electrically stimulated to measure the TF of the triceps surae muscles resulting from motor nerve activation before and after cutting or stimulating (at 5–20 Hz) the lumbar sympathetic trunk (LST). The TF amplitude decreased by cutting the LST in the young and aged groups; however, the magnitude of the decrease in TF following transection of the LST in the aged rats (6.2%) was significantly (P = 0.02) smaller compared with that in the young rats (12.9%). The TF amplitude was increased by LST stimulation at >5 Hz in the young and >10 Hz in the aged groups. The overall TF response to LST stimulation was not significantly different between the two groups; however, increases in muscle tonus resulting from LST stimulation, independent of motor nerve stimulation, was significantly (P = 0.03) greater in aged compared with young rats. The sympathetic contribution to support motor nerve-induced muscle contraction declined, whereas sympathetic-mediated muscle tonus, independent of motor nerve activity, was augmented in aged rats. These changes in sympathetic modulation of hindlimb muscle contractility may underlie the reduction of skeletal muscle strength during voluntary contraction and rigidity of motion during senescence.

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“…Hindlimb muscle nerves contain unmyelinated sympathetic postganglionic fibers, for example, which account for 40% of all nerve fibers in the combined nerve of the lateral gastrocnemius and soleus muscle of the cat 15 . These sympathetic nerve fibers appear to be distributed not only in vascular smooth muscle, but also in skeletal muscle fibers 16 and neuromuscular junctions 17 – 19 . We identified a feedback mechanism between skeletal muscle and sympathetic nerves, in which reflex excitation of the lumbar sympathetic nerves induced by contractions of the hindlimb muscles modulates their contractility 20 .…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence for adrenergic receptors on both the skeletal muscle fiber itself and on the cholinergic motor nerve terminal 17 and each target has the potential to alter the contractility of the muscle fiber when activated. The β-receptor-mediated increase in frequency of the miniature endplate potential of dissected hindlimb muscle resulting from sympathetic stimulation was reduced in aged mice (31 months old) compared with young mice (3–4 months old), suggesting a decline in the sympathetic regulation of cholinergic nerve terminals during aging 21 .…”

Section: Introductionmentioning

confidence: 99%

Sympathetic modulation of hindlimb muscle contractility is altered in aged rats

Hotta

Iimura

Watanabe

et al. 2023

Sci Rep

View full text Add to dashboard Cite

It has recently been demonstrated that reflex excitation of muscle sympathetic nerves triggered by muscle contraction contributes to the maintenance of tetanic force (TF) in rat hindlimb muscles. We hypothesized that this feedback mechanism between the contraction of hindlimb muscles and the lumbar sympathetic nerves declines during aging. In this study, we examined the contribution of sympathetic nerves on skeletal muscle contractility in young adult (4–9 months old, n = 11) and aged (32–36 months old, n = 11) male and female rats. The tibial nerve was electrically stimulated to measure the TF of the triceps surae muscles resulting from motor nerve activation before and after cutting or stimulating (at 5–20 Hz) the lumbar sympathetic trunk (LST). The TF amplitude decreased by cutting the LST in the young and aged groups; however, the magnitude of the decrease in TF following transection of the LST in the aged rats (6.2%) was significantly (P = 0.02) smaller compared with that in the young rats (12.9%). The TF amplitude was increased by LST stimulation at ≥ 5 Hz in the young and ≥ 10 Hz in the aged groups. The overall TF response to LST stimulation was not significantly different between the two groups; however, an increase in muscle tonus resulting from LST stimulation, independent of motor nerve stimulation, was significantly (P = 0.03) greater in aged compared with young rats. The sympathetic contribution to support motor nerve-induced muscle contraction declined, whereas sympathetic-mediated muscle tonus, independent of motor nerve activity, was augmented in aged rats. These changes in sympathetic modulation of hindlimb muscle contractility may underlie the reduction of skeletal muscle strength during voluntary contraction and rigidity of motion during senescence.

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Adrenoceptors Modulate Cholinergic Synaptic Transmission at the Neuromuscular Junction

Cited by 13 publications

References 75 publications

Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases

Synaptic Secretion and Beyond: Targeting Synapse and Neurotransmitters to Treat Neurodegenerative Diseases

Sympathetic modulation of hindlimb muscle contractility is altered in aged rats

Sympathetic modulation of hindlimb muscle contractility is altered in aged rats

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