Sympathetic ophthalmia after surgical resection of iridociliary melanoma. A case report

García-Arumí, José; Gil, Marc Montolio; Palau, Merce Morral; García, Antonio Segura

doi:10.1007/s00417-006-0299-1

Cited by 18 publications

(6 citation statements)

References 12 publications

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“…In many cases of sympathetic ophthalmia, however, the choriocapillaris is spared, leaving clinical history as the only means of differentiating the 2 entities. 11 Meningeal symptoms may include meningismus, vertigo, ataxia, sensorineural hearing loss, 12,13 and rarely, a cerebral vasculitis. 14 Sympathetic ophthalmia may be prevented if the injured eye is enucleated soon after the inciting event; however, this is not routinely done, especially if the injured eye has visual potential.…”

Section: Sympathetic Ophthalmiamentioning

confidence: 99%

Uveo-meningeal Syndromes

Ray

Foroozan²

2007

International Ophthalmology Clinics

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Section: Sympathetic Ophthalmiamentioning

confidence: 99%

Uveo-meningeal Syndromes

Ray

Foroozan²

2007

International Ophthalmology Clinics

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“…69 Reported complications of partial lamellar sclerouvectomy include vitreous hemorrhage, cataracts, retinal detachment, and hemorrhagic choroidal detachment. 17,34,45 These complications profoundly risk visual rehabilitation and ocular survival.…”

Section: Local Excisionmentioning

confidence: 99%

Intraocular leiomyoma: Current concepts

Tomar

Finger

Iacob

2020

Survey of Ophthalmology

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leiomyoma actin melanoma immunohistochemistry benign uvea a b s t r a c tIntraocular leiomyoma is a benign smooth muscle tumor. First recognized before the era of immunohistochemistry, uveal leiomyomas have been described in case reports and small case series. We add 3 new cases, for a total of 80. Of these, there were 29 men and 51 women. The mean and median ages were 35.8 and 30.5 years respectively, with a range of 8 to 80 years. Curiously, ciliary body tumors were more common in females, whereas iris and posterior choroidal leiomyomas were more prevalent in males. Infrequently associated with systemic fibroids, nuclear expression of sex steroid receptors was inconsistent. Iris and posterior choroidal leiomyoma were predominantly amelanotic, while 40% of ciliary body leiomyomas were brown. Two-thirds of the leiomyomas blocked transillumination partially or completely, a feature shared by uveal melanoma. In general, low-frequency ultrasound imaging reveals low to moderate internal reflectivity; however, highfrequency anterior uveal ultrasound was used to localize a leiomyoma as resident in the suprachoroidal space with an overlying layer of intact choroid. In the few cases examined by physiologic imaging, increased metabolic activity (typically associated with malignancy and inflammation) has been noted. We found that pigmented uveal leiomyomas can be clinically identical to melanoma. Therefore, histopathology with immunohistochemical staining for smooth muscle actin was the most reliable diagnostic method to differentiate pigmented uveal leiomyoma from melanoma. Treatment is governed by the clinical diagnosis, tumor size and location, as well as prognosis for vision and globe preservation.

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“…[3][4][5][6][7][8][9][10] Contemporary literature has hypothesized an association between surgical resection or radiotherapy for choroidal melanoma and subsequent development of SO. [11][12][13][14] The exact pathophysiology of SO remains unknown; however, it does appear to be an autoimmune hypersensitivity reaction against exposed ocular antigens in the inciting eye as well as the sympathizing eye. 1,2 We report an unusual case of SO prompted by an untreated choroidal melanoma in the fellow eye.…”

Section: Sympathetic Ophthalmia Associated With Untreated Choroidal Mmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10] Choroidal melanoma treatment strategies, including radiotherapy, brachytherapy, and surgical excision, have been reported as "stimulating" factors for SO in the current literature. [11][12][13][14] The presumed exposure to uveal antigens during these procedures is postulated to be the likely etiology.…”

Section: Sympathetic Ophthalmia Associated With Untreated Choroidal Mmentioning

confidence: 99%

Sympathetic ophthalmia associated with untreated choroidal melanoma

Vaidehi

Haider

Dunlop

et al. 2018

Canadian Journal of Ophthalmology

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6. Saari M, Vuorre I, Nieminen H. Infra-red transillumiantion stereophotgraphy of the iris in Fuchs's heterochromatic cyclitis. Br J Ophtalmol. 1978;62:110-5. 7. Ngo W, Srinivasan S, Jones L. Histroical overviewof imaging the meibomian glands. J Optom. 2013;6:1-8. 8. Krohn J, Ulltang J, Kjersem B. Near-infrared transillumination photography of intraocular tumors. Br J Ophthalmol. 2013;97:1244-6. 9. Chan EC, Roberts DK, Loconte DD, Wernick MN. Digital camera system to perform infrared photography of iris transillumination.

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Sympathetic ophthalmia after surgical resection of iridociliary melanoma. A case report

Abstract: Sympathetic ophthalmia is a rare, but severe disease that can occur after resection of iridociliary melanoma. High-dose steroid therapy and supplementation with immunosuppressive agents early in the course of the disease was effective in resolving the condition.

Cited by 18 publications

References 12 publications

Uveo-meningeal Syndromes

Uveo-meningeal Syndromes

Intraocular leiomyoma: Current concepts

Sympathetic ophthalmia associated with untreated choroidal melanoma

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