2015
DOI: 10.1590/1516-4446-2014-1619
|View full text |Cite
|
Sign up to set email alerts
|

Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates

Abstract: Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and poly… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
8
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 8 publications
(10 citation statements)
references
References 37 publications
(32 reference statements)
2
8
0
Order By: Relevance
“…Heterogeneous distribution within a population of animals (see Fig. 5) (Korff et al, 2008) suggests a genetic association akin to OCD (Lochner et al, 2015). While the prevalence of OCD is markedly lower than that of high stereotypic (H) animals in a deer mouse population (45%, Fig.…”
Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning
confidence: 99%
“…Heterogeneous distribution within a population of animals (see Fig. 5) (Korff et al, 2008) suggests a genetic association akin to OCD (Lochner et al, 2015). While the prevalence of OCD is markedly lower than that of high stereotypic (H) animals in a deer mouse population (45%, Fig.…”
Section: Insights Into Ocd From the Deer Mouse: A Platform For Resmentioning
confidence: 99%
“…The mixed clinical presentation and treatment outcomes across symptom domains may suggest different underlying mechanisms (Rasmussen et al., ). Indeed, genetic investigations have demonstrated unique associations with variants of particular neurotransmitter receptor and transporter genes (Lochner et al., ; Viswanath et al., ). Neuroimaging studies offer evidence suggesting S/O and O/C dimensions may relate also to different structural and functional patterns.…”
Section: Introductionmentioning
confidence: 99%
“…Functional neuroimaging studies suggest that OCD dimensions may be mediated by partially distinct subjacent neurocircuits [ 18 , 19 ], and that among them, the symmetry dimension may have unique genetic [ 20 , 21 ] and neural [ 18 , 19 ], correlates. In neuropsychological studies, higher scores in the symmetry dimension were associated with poorer verbal fluency, which involves set shifting capacity and cognitive flexibility [ 22 , 23 , 24 ].…”
Section: Introductionmentioning
confidence: 99%
“…Regarding demographic and clinical correlates, the symmetry dimension has been associated with male sex [ 4 , 17 , 25 , 26 , 27 , 28 , 29 ], early onset of obsessive–compulsive symptoms [ 8 , 27 , 28 , 30 , 31 , 32 , 33 , 34 , 35 ], longer duration of symptoms [ 21 , 27 , 36 ], and presence of tics or tic disorders [ 37 , 38 ]. Additionally, associations with family history of OCD [ 8 , 39 , 40 , 41 , 42 ], greater OCD severity and functional impairment [ 16 , 21 , 26 , 32 ], and suicidal behaviors [ 43 , 44 ] have been reported.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation