Does neuropsychological performance in OCD relate to different symptoms? A meta-analysis comparing the symmetry and obsessing dimensions

Bragdon, Laura B.; Gibb, Brandon E.; Coles, Meredith E.

doi:10.1002/da.22785

Cited by 41 publications

(31 citation statements)

References 128 publications

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“…Taken together, our results showed from a cross-species perspective that a link between compulsion and behavioral flexibility is not supported but rather they suggest that other dimensions found in subgroups of compulsive subjects, such as excessive response lability, have an effect on behavioral flexibility. Our study also emphasizes the importance of considering clinical subtypes within OCD patients, as encouraged by other recent studies (60,61).…”

Section: Discussionsupporting

confidence: 72%

A cross-species assessment of behavioral flexibility in compulsive disorders

Benzina

N’Diaye

Pélissolo

et al. 2019

Preprint

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Short running title: Flexibility and compulsive behaviors in mice and menABSTRACT Background: Compulsive behaviors, one of the core symptoms of Obsessive-Compulsive Disorder (OCD), are defined as repetitive behaviors performed through rigid rituals. The lack of behavioral flexibility has been as being one of the primary causes of compulsions, but studies exploring this dimension have shown inconsistencies in different tasks performed in human and animal models of compulsive behavior. The aim of this study was so to assess the involvement of behavioral flexibility in compulsion, with a similar approach across different species sharing a common symptom of compulsivity.Methods: 40 OCD patients, 40 healthy individually matched control subjects, 26 C57BL/6J Sapap3 KO mice and 26 matched wildtype littermates were included in this study. A similar reversal learning task was designed to assess behavioral flexibility in parallel in these two species.Results: When considered as homogeneous groups, OCD patients and KO mice expressing compulsive behaviors did not significantly differ from their controls regarding behavioral flexibility. When clinical subtypes were considered, only patients exhibiting checking compulsions were impaired with more trials needed to reach the reversal criterion. In KO mice, a similarly impaired subgroup was identified. For both species, this impairment did not result in a greater perseveration after reversal, but in a greater lability in their responses in the reversal condition. Moreover, this impairment did not correlate with the severity of compulsive behaviors. Conclusions:In our cross-species study, we found no consistent link between compulsive behaviors and a lack of behavioral flexibility. However, we showed in both species that the compulsive group was heterogeneous in term of performance in our reversal learning task. Among the compulsive subjects, we identified a subgroup with impaired performance not due to perseverative and rigid behaviors as commonly hypothesized, but rather to an increase in response lability.

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Section: Discussionsupporting

confidence: 72%

A cross-species assessment of behavioral flexibility in compulsive disorders

Benzina

N’Diaye

Pélissolo

et al. 2019

Preprint

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“…2,3 These dimensions have been found to be fairly consistent across youth and adult patient samples, with some individual studies showing partially agedependent structures. 3,4 Research to establish the validity of these dimensions has primarily involved factor and principal component analytic studies 3 and to a lesser extent studies examining the relationship between individual symptom dimensions and heritability 5,6 , neural substrates 7,8 , cognitive functioning 9 , comorbidity 4,10 , and treatment outcome 11,12 . Although hoarding disorder is now recognized as separate from OCD in DSM-5 and ICD-11, the differential diagnosis with OCD is still important as hoarding symptoms can be conceptualized as obsessions and compulsions in a minority of children and adults with OCD.…”

Section: Introductionmentioning

confidence: 99%

The Centrality of Doubting and Checking in the Network Structure of Obsessive-Compulsive Symptom Dimensions in Youth

Cervin

Perrin

Olsson³

et al. 2020

Journal of the American Academy of Child & Adolescent Psych

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Current evidence suggests that separate cerebellar regions are connected with different cerebral areas to form multiple cognitive circuits with topographic functions (15, 16). These functions include attention, language, working memory, visuospatial processing, and decision-making (14), which have been reported to be deficient in OCD patients (17, 18). This information is inevitably reminiscent of the role of cerebellar–cerebral functional connectivity in OCD.…”

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity Between the Cerebellum and the Cortico-Striato-Thalamo-Cortical Circuit in Obsessive-Compulsive Disorder

Zhang

et al. 2019

Front. Psychiatry

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Background: Altered resting-state functional connectivity of the cerebellum in obsessive-compulsive disorder (OCD) has been previously reported. However, the previous study investigating cerebellar–cerebral functional connectivity relied on a priori –defined seeds from specific networks. In this study, we aimed to explore the connectivity alterations of the cerebellum in OCD under resting-state conditions with a hypothesis-free approach. Methods: Thirty patients with OCD and 26 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) scanning at resting state. Regional cerebral function was evaluated by measuring the fraction of amplitude of low-frequency fluctuation (fALFF). Regions with mean fALFF (mfALFF) alterations were used as seeds in seed correlation analysis (SCA). An independent samples t test was used to compare the differences in mfALFF and functional connection (FC) between the two groups. Pearson correlation analysis was performed to identify the association between functional neural correlates and OCD symptom severity evaluated using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: Compared with the HC group, the OCD group showed significantly increased mfALFF values in bilateral cerebellar. The results of FC analysis showed weakened connectivity among the left Crus II, lobule VIII, and right striatum and between the right lobule VIII and the right striatum, and cingulate in the OCD group compared with the HC group. Some of the abovementioned results were associated with symptom severity. Conclusions: OCD patients showed abnormal spontaneous cerebellar activity and weakened functional connectivity between the cerebellum and the cortico-striato-thalamo-cortical (CSTC) circuit (striatum and cingulate), suggesting that the cerebellum may play an essential role in the pathophysiology of OCD.

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Does neuropsychological performance in OCD relate to different symptoms? A meta-analysis comparing the symmetry and obsessing dimensions

Abstract: Findings support existing evidence suggesting that different OCD symptoms, and their associated core motivations, relate to unique patterns of neuropsychological functioning, and, potentially dysfunction in different neural circuits.

Cited by 41 publications

References 128 publications

A cross-species assessment of behavioral flexibility in compulsive disorders

A cross-species assessment of behavioral flexibility in compulsive disorders

The Centrality of Doubting and Checking in the Network Structure of Obsessive-Compulsive Symptom Dimensions in Youth

Altered Functional Connectivity Between the Cerebellum and the Cortico-Striato-Thalamo-Cortical Circuit in Obsessive-Compulsive Disorder

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