Smooth and symplectic symmetries of an infinite family of distinct exotic K3 surfaces are studied, and a comparison with the corresponding symmetries of the standard K3 is made. The action on the K3 lattice induced by a smooth finite group action is shown to be strongly restricted, and, as a result, the nonsmoothability of actions induced by a holomorphic automorphism of prime order at least 7 is proved, and the nonexistence of smooth actions by several K3 groups is established (included among which is the binary tetrahedral group T24 that has the smallest order). Concerning symplectic symmetries, the fixed-point set structure of a symplectic cyclic action of prime order at least 5 is explicitly determined, provided that the action is homologically nontrivial.Corollary 1.3. Any locally linear topological action induced by an automorphism of a K3 surface of prime order at least 7 is nonsmoothable on X α .Proof. Let g be an automorphism of a K3 surface of prime order p 7. If g is nonsymplectic, then g is not smoothable on X α by Theorem 1.1(1). Suppose that g is a symplectic automorphism. Then, by Nikulin [44], we have p = 7 and, moreover, the action of g is pseudofree with three isolated fixed points. Suppose that g is smoothable on X α . Then, by Theorem 1.1(2) and Lemma 4.5, the trace of the action of g on H 2 (X α ; Z) is at least 8, so that, by the Lefschetz fixed-point theorem (cf. Theorem 3.4), the Euler number of the fixed-point set of g is at least 10. Thus we have a contradiction.Next we turn our attention to smooth involutions, that is, smooth Z 2 -actions on X α . Let g : X α → X α be any smooth involution. Since X α is simply connected, g can be lifted to the spin bundle over X α , where there are two cases:(1) g is of even type, meaning that the order of lifting to the spin bundle is 2; or (2) g is of odd type, meaning that the order of lifting to the spin bundle is 4.