Symmetrical onychomadesis in Norwegian Gordon and English setters

Ziener, Martine Lund; Bettenay, S. V.; Mueller, Ralf S.

doi:10.1111/j.1365-3164.2008.00650.x

Cited by 16 publications

(30 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In dogs, SLO is a significant health concern and appears to be the most common immune-mediated claw disease [4]. Particularly high disease prevalence has been reported in certain breeds such as Gordon setters (12.6%) [13], [2]. English setters, giant schnauzers (10%) and also bearded collies are reported to have a high incidence of SLO (unpublished observation).…”

Section: Introductionmentioning

confidence: 94%

DLA Class II Alleles Are Associated with Risk for Canine Symmetrical Lupoid Onychodystropy (SLO)

et al. 2010

View full text Add to dashboard Cite

Symmetrical lupoid onychodystrophy (SLO) is an immune-mediated disease in dogs affecting the claws with a suggested autoimmune aethiology. Sequence-based genotyping of the polymorphic exon 2 from DLA-DRB1, -DQA1, and -DQB1 class II loci were performed in a total of 98 SLO Gordon setter cases and 98 healthy controls. A risk haplotype (DRB1*01801/DQA1*00101/DQB1*00802) was present in 53% of cases and 34% of controls and conferred an elevated risk of developing SLO with an odds ratio (OR) of 2.1. When dogs homozygous for the risk haplotype were compared to all dogs not carrying the haplotype the OR was 5.4. However, a stronger protective haplotype (DRB1*02001/DQA1*00401/DQB1*01303, OR = 0.03, 1/OR = 33) was present in 16.8% of controls, but only in a single case (0.5%). The effect of the protective haplotype was clearly stronger than the risk haplotype, since 11.2% of the controls were heterozygous for the risk and protective haplotypes, whereas this combination was absent from cases. When the dogs with the protective haplotype were excluded, an OR of 2.5 was obtained when dogs homozygous for the risk haplotype were compared to those heterozygous for the risk haplotype, suggesting a co-dominant effect of the risk haplotype. In smaller sample sizes of the bearded collie and giant schnauzer breeds we found the same or similar haplotypes, sharing the same DQA1 allele, over-represented among the cases suggesting that the risk is associated primarily with DLA-DQ. We obtained conclusive results that DLA class II is significantly associated with risk of developing SLO in Gordon setters, thus supporting that SLO is an immune-mediated disease. Further studies of SLO in dogs may provide important insight into immune privilege of the nail apparatus and also knowledge about a number of inflammatory disorders of the nail apparatus like lichen planus, psoriasis, alopecia areata and onycholysis.

show abstract

Section: Introductionmentioning

confidence: 94%

DLA Class II Alleles Are Associated with Risk for Canine Symmetrical Lupoid Onychodystropy (SLO)

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Atopic dermatitis, adverse food reactions and immune‐mediated disorders (e.g. pemphigus foliaceus, lupus erythematosus, vasculitis) have been reported as causes of lupoid onychomadesis . Drug reactions due to vaccinations also were suspected, although in one study evaluating 24 dogs with onychomadesis there was no evidence of a vaccine reaction …”

Section: Introductionmentioning

confidence: 99%

Canine symmetrical lupoid onychomadesis in bearded collies

Steimer¹,

Bauer

Kienzle

et al. 2019

Veterinary Dermatology

Self Cite

View full text Add to dashboard Cite

Background Symmetrical lupoid onychomadesis (SLO) is a disease not infrequently seen in bearded collie dogs in Germany. Objectives The aim of this study was to compare historical and clinical data, as well as the mineral content of the hair and claws of bearded collies with SLO with that of normal control dogs. Animals Twenty‐eight affected bearded collie dogs and 39 control dogs. Methods and materials Owners completed an extensive questionnaire regarding upbringing, environmental conditions and diets. Claw specimens were obtained by claw trimming or gathering lost claws; hairs were obtained by plucking samples from several areas of the body; samples were converted to ash and evaluated in an atomic absorption spectrophotometer. Results Clinical signs in affected dogs eventually involved all claws on all paws. In twelve dogs recurrence of onychomadesis was observed. There was no relevant association between gender, housing, diet and health management, physical stress and the development of SLO with exception of the age at which more intense exercise began. The most commonly used treatment combination was fatty acids, pentoxifylline and tetracycline; improvement occurred in 17 animals. Calcium, sodium and phosphorus concentrations were higher in the claws of affected dogs, whereas zinc concentrations were lower. The mineral content of hair samples of the affected dogs was not significantly different than controls. Conclusion and clinical importance Symmetrical lupoid onychomadesis in bearded collies is clinically similar to what has been described in other breeds with regard to clinical signs and response to treatment. Early strenuous activity may increase the risk for disease occurrence in this breed.

show abstract

“…Moreover, Ziener et al . () observed higher prevalence of SO among siblings of dogs with SO compared to unrelated dogs. Histopathological changes reported in claws affected by SO and examples of successful treatment of affected dogs with immunosuppressive drugs and fatty acid supplementation suggest an autoimmune aetiology (Scott et al .…”

Section: Introductionmentioning

confidence: 89%

“…; Bergvall ; Ziener et al . ). The inheritance of SO is most likely complex and caused by a combination of numerous genetic and environmental factors.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

A genome‐wide association study identifies a region strongly associated with symmetrical onychomadesis on chromosome 12 in dogs

2016

View full text Add to dashboard Cite

Symmetrical onychomadesis causes periodic loss of claws in otherwise healthy dogs. Genome-wide association analysis in 225 Gordon Setters identified a single region associated with symmetrical onychomadesis on chromosome 12 (spanning about 3.3 mb). A meta-analysis including also English Setters indicated that this genomic region predisposes for symmetrical onychomadesis in English Setters as well. The associated region spans most of the major histocompatibility complex and nearly 1 Mb downstream. Like many other autoimmune diseases, associations of symmetrical onychomadesis with DLA class II alleles have been reported. In this study, no associated markers were revealed within any of the DLA-DRB1, -DQA1 or -DQB1 genes, and the odds for symmetrical onychomadesis in the Gordon Setters were much higher, carrying significant single nucleotide polymorphisms compared to the odds of any of the recorded DLA-DRB1/DQA1/DQB1 haplotypes. We noticed that some of the associated DLA haplotypes were different between the English Setters and the Gordon Setters. Interestingly, associated SNP chip markers showed a more consistent pattern of allelic variants related to cases or controls regardless of breed. In conclusion, the associated genetic markers identified in this study hold the potential to aid in selection of breeding animals to reduce the frequency of symmetrical onychomadesis in the dog.

show abstract

Symmetrical onychomadesis in Norwegian Gordon and English setters

Cited by 16 publications

References 9 publications

DLA Class II Alleles Are Associated with Risk for Canine Symmetrical Lupoid Onychodystropy (SLO)

DLA Class II Alleles Are Associated with Risk for Canine Symmetrical Lupoid Onychodystropy (SLO)

Canine symmetrical lupoid onychomadesis in bearded collies

A genome‐wide association study identifies a region strongly associated with symmetrical onychomadesis on chromosome 12 in dogs

Contact Info

Product

Resources

About