Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis

Kielstein, Jan T.; Salpeter, Shelley R.; Bode-Boeger, Stefanie M.; Cooke, John P.; Fliser, Danilo

doi:10.1093/ndt/gfl292

Cited by 317 publications

(293 citation statements)

References 44 publications

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“…This intriguing finding is in accordance with the results of a recent meta-analysis (44) and therefore lends support to the premise that SDMA constitutes a novel marker of renal function. Further investigations would establish the role of SDMA as a reliable index of renal function.…”

Section: Discussionsupporting

confidence: 91%

Role of Nitric Oxide–Producing and–Degrading Pathways in Coronary Endothelial Dysfunction in Chronic Kidney Disease

Tatematsu¹,

Wakino²,

Kanda³

et al. 2007

Journal of the American Society of Nephrology

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Section: Discussionsupporting

confidence: 91%

Role of Nitric Oxide–Producing and–Degrading Pathways in Coronary Endothelial Dysfunction in Chronic Kidney Disease

Tatematsu¹,

Wakino²,

Kanda³

et al. 2007

Journal of the American Society of Nephrology

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“…We also reported recently that SDMA is a prospective marker of total mortality after ischemic stroke (19). Several explanations for this observation including increased formation of reactive oxygen species, competition for L-arginine transport into endothelial cells, or valid reflection of renal function by SDMA have been proposed (18,20,21).…”

Section: Introductionmentioning

confidence: 79%

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians

Schutte¹,

Schutte²,

Huisman³

et al. 2010

European Journal of Endocrinology

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Objective: Alarming increases in hypertension and type 2 diabetes among Africans accentuate the need to identify factors that could serve as targets for prevention or treatment. In Caucasian populations, asymmetric dimethylarginine (ADMA), the predominant endogenous nitric oxide synthase inhibitor, is associated with cardiovascular disease and insulin resistance (IR). ADMA's counterpart, symmetric dimethylarginine (SDMA), originally thought to be inert, was recently also linked with cardiovascular risk. Since little information regarding ADMA or SDMA is available for Africans, our aim was to explore the relationships of ADMA and SDMA with measures of arterial stiffness and IR in Africans and Caucasians from South Africa. Methods: The study consisted of 235 nonsmoking, nondiabetic, nonobese, human immunodeficiency virus-uninfected Africans (nZ64) and Caucasians (nZ171), aged 20-70 years. We measured blood pressure, pulse wave velocity, ADMA, SDMA, and IR (homeostasis model assessment, HOMA). Results: African and Caucasian men had similar ADMA and SDMA, whereas Caucasian women had higher ADMA and SDMA than African women (P!0.05). African men and Caucasian women indicated strong correlations of ADMA with arterial stiffness (rZ0.47, PZ0.021; rZ0.26, PZ0.008), confirmed in multivariate analyses. Caucasian participants showed negative associations between SDMA and HOMA, being strongest in the men (rZK0.41; PZ0.002). Conclusion: Our results indicate that ADMA is independently associated with vascular dysfunction in African men and Caucasian women. A strong, independent negative association of SDMA with IR was found only in Caucasian participants. The molecular explanation for this is unclear, but these findings motivate experimental studies that could shed more light on these relationships.

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“…However, it has been questioned whether elevated circulating levels of ADMA are merely a marker of kidney disease, coinciding with serum creatinine, or part of the pathophysiological process [20]. Indeed, plasma levels of SDMA correlated more closely with parameters of renal function than did plasma levels of ADMA [21].…”

Section: Discussionmentioning

confidence: 99%

Dimethylarginine Dimethylaminohydrolase 2 Gene Polymorphism and Its Association with Asymmetrical Dimethyl Arginine in Hemodialyzed Patients

Yusuf¹,

Thaha²,

Yogiarto³

et al. 2013

OJNeph

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Introduction: Patients with CKD have elevated plasma levels of Asymmetrical Dimethyl Arginine (ADMA), impaired EDRF/NO responses in isolated resistance vessels, and a marked increase in the frequency of cardiovascular events that are predicated by plasma levels of ADMA. ADMA is considered as a risk factor for endothelial dysfunction, progression of chronic kidney disease and a marked increase in the frequency of cardiovascular events that are predicated by plasma levels of ADMA. Elevated ADMA in CKD have been related to a combination of a reduced renal ADMA excretion and a reduced catabolism of ADMA by dimethylarginine dimethylaminohydrolase (DDAH). The current study was undertaken to determine whether there is a correlation between ADMA and SNPs at −449 DDAH 2. Subjects and Methods: It was a cross sectional analytic study, 56 hemodialysis patients and 30 healthy individuals were enrolled. Based on its etiology, HD patients group was further divided in to hypertension (HT) subgroup and non-HT subgroup. Genotyping of the polymorphisms was performed using PCR-based SNP detection methods based on 5'-exonuclease activity assays for rs805305. Results: Heterozygotes were observed as the most abundant genotypes in both groups, followed by GG genotype in the HD patients (30%) and CC (27%) healthy individuals. Among the HT subgroup, the mean plasma levels of ADMA were sequentially higher from genotypes CC, G/C and GG (p = 0.037). Further multiple comparisons between groups using post hoc test showed results that genotype GG and CC were different at 0.05 level of significance. These findings were not found among non HT subgroup. Conclusion: Genetic variation in the DDAH 2 genes is significantly associated with serum ADMA levels in hypertensive HD patients. We observed that carriage of a G at position −449 in the promoter region of the DDAH 2 gene is associated with higher ADMA levels.

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Symmetric dimethylarginine (SDMA) as endogenous marker of renal function—a meta-analysis

Abstract: SDMA exhibits some properties of a reliable marker of renal function. Future studies have to clarify whether SDMA is indeed suited to improve diagnosis and eventually optimize care of patients.

Cited by 317 publications

References 44 publications

Role of Nitric Oxide–Producing and–Degrading Pathways in Coronary Endothelial Dysfunction in Chronic Kidney Disease

Role of Nitric Oxide–Producing and–Degrading Pathways in Coronary Endothelial Dysfunction in Chronic Kidney Disease

Dimethylarginines: their vascular and metabolic roles in Africans and Caucasians

Dimethylarginine Dimethylaminohydrolase 2 Gene Polymorphism and Its Association with Asymmetrical Dimethyl Arginine in Hemodialyzed Patients

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