“…It has been demonstrated that transcriptomic sequence is predictive of the PHO and PKA signaling pathways in G. margarita ( Salvioli et al, 2016). In brief, the PHO pathway consists of the upstream signaling components (VIP1, IP7, Pho81, Pho80, Pho85, NUC-1, and Pho2) and the downstream transcriptional outputs (Pho5, Pho12, ALP-2, GigmPT1-5), and the PKA pathway is composed of the core signaling cascade (TPK1-3, Bcy1, Rim15, Msn4, and Rap1) and PKA targets (NTH1, TPS2, TSL1, STRE-driven genes, and ribosomal gene) ( Table 1).…”