Switching Outpatients With Bipolar or Schizoaffective Disorders and Substance Abuse From Their Current Antipsychotic to Aripiprazole

Brown, E. Sherwood; Jeffress, Jala; Liggin, Joshua D.M.; Garza, Monica; Beard, Laura

doi:10.4088/jcp.v66n0613

Cited by 110 publications

(67 citation statements)

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“…Furthermore, aripiprazole might be effective in special populations of cocaine-dependent patients. For example, in schizophrenic patients, aripiprazole decreased the number of cocaine-positive urines (22), and in another study in patients with bipolar or schizoaffective disorder, aripiprazole reduced cocaine craving (23), suggesting that aripiprazole would be useful in cocaine-dependent individuals with co-existing psychiatric conditions. Thus, the efficacy of aripiprazole to manage cocaine dependence remains to be determined.…”

Section: Discussionmentioning

confidence: 95%

The Safety, Tolerability, and Subject-Rated Effects of Acute Intranasal Cocaine Administration During Aripiprazole Maintenance II: Increased Aripipirazole Dose and Maintenance Period

Lile

Stoops

Hays

et al. 2008

The American Journal of Drug and Alcohol Abuse

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Objectives-This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance.Methods-Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine.Results-Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated) and aripiprazole enhanced these effects on several measures.Conclusions-15 mg/day aripiprazole is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.

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Section: Discussionmentioning

confidence: 95%

The Safety, Tolerability, and Subject-Rated Effects of Acute Intranasal Cocaine Administration During Aripiprazole Maintenance II: Increased Aripipirazole Dose and Maintenance Period

Lile

Stoops

Hays

et al. 2008

The American Journal of Drug and Alcohol Abuse

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“…In 2005, Brown and colleagues 35 conducted an open-label, pilot trial with aripiprazole in 20 antipsychotic-treated patients with bipolar or schizoaffective disorder and current substance abuse. Patients were switched to open-label aripiprazole using an overlap and taper method.…”

Section: Previous Datamentioning

confidence: 99%

“…48 Moreover, Anton and colleagues 49 found more positive subjective treatment effects and less overall severity of alcohol dependence in subjects treated with aripiprazole as compared with placebo. Finally, Brown and colleagues 35 found significant reductions in dollars spent on alcohol and alcohol craving by aripiprazole in bipolar (or schizoaffective) alcoholic patients. These results suggest that the efficacy of aripiprazole in alcohol use disorders of bipolar patients should be further investigated.…”

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confidence: 96%

Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism

Azorin

Bowden²,

Garay

et al. 2010

NDT

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About half of all bipolar patients have an alcohol abuse problem at some point of their lifetime. However, only one randomized, controlled trial of pharmacotherapy (valproate) in this patient population was published as of 2006. Therefore, we reviewed clinical trials in this indication of the last four years (using mood stabilizers, atypical antipsychotics, and other drugs). Priority was given to randomized trials, comparing drugs with placebo or active comparator. Published studies were found through systematic database search (PubMed, Scirus, EMBASE, Cochrane Library, Science Direct). In these last four years, the only randomized, clinically relevant study in bipolar patients with comorbid alcoholism is that of Brown and colleagues (2008) showing that quetiapine therapy decreased depressive symptoms in the early weeks of use, without modifying alcohol use. Several other open-label trials have been generally positive and support the efficacy and tolerability of agents from different classes in this patient population. Valproate efficacy to reduce excessive alcohol consumption in bipolar patients was confirmed and new controlled studies revealed its therapeutic benefit to prevent relapse in newly abstinent alcoholics and to improve alcohol hallucinosis. Topiramate deserves to be investigated in bipolar patients with comorbid alcoholism since this compound effectively improves physical health and quality of life of alcohol-dependent individuals. In conclusion, randomized, controlled research is still needed to provide guidelines for possible use of valproate and other agents in patients with a dual diagnosis of bipolar disorder and substance abuse or dependence.

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“…L'aripiprazole, un agoniste partiel dopaminergique D2, réduit le « craving » mais pas la fréquence des prises de cocaïne, dans une étude chez des patients bipolaires ou schizoaffectifs ayant également un abus ou une dépendance à la cocaïne [6]. gabapentin, facilitateur de la libération de GABA ; tiagabine, inhibiteur de la recapture du GABA) semblent également efficaces pour réduire les prises compulsives de cocaïne [15,21,25].…”

Section: Thérapeutiqueunclassified

Le point sur l’addiction à la cocaïne et au crack

Charles-Nicolas

Lacoste

Ballon

2009

Annales Médico-psychologiques, revue psychiatrique

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Switching Outpatients With Bipolar or Schizoaffective Disorders and Substance Abuse From Their Current Antipsychotic to Aripiprazole

Cited by 110 publications

References 0 publications

The Safety, Tolerability, and Subject-Rated Effects of Acute Intranasal Cocaine Administration During Aripiprazole Maintenance II: Increased Aripipirazole Dose and Maintenance Period

The Safety, Tolerability, and Subject-Rated Effects of Acute Intranasal Cocaine Administration During Aripiprazole Maintenance II: Increased Aripipirazole Dose and Maintenance Period

Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism

Le point sur l’addiction à la cocaïne et au crack

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