Switchable Supracolloidal Coassembly of Microgels Mediated by Host/Guest Interactions

Han, Kang; Go, Dennis; Hoenders, Daniel; Kuehne, Alexander J. C.; Walther, Andreas

doi:10.1021/acsmacrolett.7b00053

Cited by 33 publications

(37 citation statements)

References 44 publications

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“…When α‐CD‐MG and Azo‐NG are mixed in deionized water (pH ≈ 6.0), no self‐assembly behavior is observed (data not shown). It is because the residual acrylic acid groups on both the guest colloid and host colloid are charged and providing a long‐ranged Columbic repulsion that repels the aggregation of colloids . Therefore, to achieve efficient supramolecular complexation, the pH of the mixed dispersion is adjusted to pH 4.2 with hydrochloric acid, where the acrylic acid groups are protonized and the Columbic repulsion is suppressed.…”

Section: Resultsmentioning

confidence: 99%

“…Because of their good selectivity, high efficiency, and stimuli responsiveness, host−guest interactions have been applied in the construction of functional hard colloids and self‐recognition of macroscopic hydrogel . However, report on the host–guest self‐assembly of microgels is rare and it remains unclear how the softness and deformability of the microgel influence the self‐assembly structure.…”

Section: Introductionmentioning

confidence: 99%

“…[29] However, reversible control to the assembly/disassembly of the microgel cluster is still a challenge.Because of their good selectivity, high efficiency, and stimuli responsiveness, host−guest interactions have been applied in the construction of functional hard colloids and self-recognition of macroscopic hydrogel. [30][31][32][33] However, report on the host-guest self-assembly of microgels is rare [34] and it remains unclear how the softness and deformability of the microgel influence the selfassembly structure. Azobenzene moiety can be included into the inner hydrophobic cavities of cyclodextrin (CD), forming up a supramolecular complex that can associate/disassociate upon the stimuli of light.…”

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confidence: 99%

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Light‐Switchable Supramolecular Self‐Assembly of Soft Colloids

Wang

Yang

et al. 2017

Macro Chemistry & Physics

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Self‐assembly is an efficient strategy of constructing microgel‐based intelligent materials. However, it remains a challenge to realize the reversible self‐assembly of microgels. Herein, a method to guide the self‐assembly of soft colloids with light‐stimuli is proposed, utilizing the light‐responsive host–guest interaction between an azobenzene functionalized nanogel (the guest colloid) and an α‐cyclodextrin functionalized microgel (the host colloid). The two colloids can form a stable colloid cluster when the surface of the host colloid is fully packed with the guest colloids. The colloid cluster can disassemble when irradiated with UV light and reassemble when irradiated with visible light. The reversible colloidal self‐assembly can be controlled by the interplay between the supramolecular and covalent crosslinking, and can also be adjusted by the addition of competitive host molecules. Besides the light‐sensitivity, the colloid cluster inherits the deformability and temperature‐sensitivity from its parent colloids. These features are different from the supramolecular self‐assembly of hard colloids or macroscopic gels, and manifest the as‐prepared colloid cluster potential building blocks of light‐responsive materials.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Light‐Switchable Supramolecular Self‐Assembly of Soft Colloids

Wang

Yang

et al. 2017

Macro Chemistry & Physics

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“…[68][69][70][71][72][73] The cyclodextrines/ azobenzenes host/guest interaction is based on the azobenzene in trans-conformation fitting into the cavity of cyclodextrines (α-, β-, or γ-cyclodextrine). [68,69] This interaction has been used to assemble Janus particles (colloidal particles with asymmetric surface properties) into superstructures. [68,69] This interaction has been used to assemble Janus particles (colloidal particles with asymmetric surface properties) into superstructures.…”

Section: Stimuli Responsive Synthetic Cell-cell Adhesionmentioning

confidence: 99%

Mimicking Adhesion in Minimal Synthetic Cells

et al. 2019

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Cell adhesions to the extracellular matrix and to neighboring cells are fundamental to cell behavior and have also been implemented into minimal synthetic cells, which are assembled from molecular building blocks from the bottom‐up. Investigating adhesion in cell mimetic models with reduced complexity provides a better understanding of biochemical and biophysical concepts underlying the cell adhesion machinery. In return, implementing cell–matrix and cell–cell adhesions into minimal synthetic cells allows reconstructing cell functions associated with cell adhesions including cell motility, multicellular prototissues, fusion of vesicles, and the self‐sorting of different cell types. Cell adhesions have been mimicked using both the native cell receptors and reductionist mimetics providing a variety of specific, reversible, dynamic, and spatiotemporally controlled interactions. This review gives an overview of different minimal adhesion modules integrated into different minimal synthetic cells drawing inspiration from cell and colloidal science.

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“…Colloids are great models to establish concepts of self‐assembly and self‐sorting as units of advanced materials and for the assembly of synthetic cells into prototissues . Decorating colloids with DNA, proteins, and supramolecular interaction partners allows to program their self‐assembly and modify assemblies in response to external triggers such as temperature, pH, and light . Among these stimuli, photoresponsive assemblies are especially attractive since light provides noninvasive, tunable, and specific control with high spatiotemporal resolution …”

mentioning

confidence: 99%

Independent Blue and Red Light Triggered Narcissistic Self‐Sorting Self‐Assembly of Colloidal Particles

Şentürk

Chervyachkova

et al. 2019

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The ability of living systems to self‐sort different cells into separate assemblies and the ability to independently regulate different structures are one ingredient that gives rise to their spatiotemporal complexity. Here, this self‐sorting behavior is replicated in a synthetic system with two types of colloidal particles; where each particle type independently self‐assembles either under blue or red light into distinct clusters, known as narcissistic self‐sorting. For this purpose, each particle type is functionalized either with the light‐switchable protein VVDHigh or Cph1, which homodimerize under blue and red light, respectively. The response to different wavelengths of light and the high specificity of the protein interactions allows for the independent self‐assembly of each particle type with blue or red light and narcissistic self‐sorting. Moreover, as both of the photoswitchable protein interactions are reversible in the dark; also, the self‐sorting is reversible and dynamic. Overall, the independent blue and red light controlled self‐sorting in a synthetic system opens new possibilities to assemble adaptable, smart, and advanced materials similar to the complexity observed in tissues.

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Switchable Supracolloidal Coassembly of Microgels Mediated by Host/Guest Interactions

Cited by 33 publications

References 44 publications

Light‐Switchable Supramolecular Self‐Assembly of Soft Colloids

Light‐Switchable Supramolecular Self‐Assembly of Soft Colloids

Mimicking Adhesion in Minimal Synthetic Cells

Independent Blue and Red Light Triggered Narcissistic Self‐Sorting Self‐Assembly of Colloidal Particles

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