Switchable Bifunctional Stimuli‐Triggered Poly‐<i>N</i>‐Isopropylacrylamide/DNA Hydrogels

Guo, Weiwei; Lü, Chunhua; Qi, Xiujuan; Orbach, Ron; Fadeev, Michael; Yang, Huang‐Hao; Willner, Itamar

doi:10.1002/anie.201405692

Cited by 174 publications

(135 citation statements)

References 60 publications

(17 reference statements)

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“…Therefore, heating the gel to 45°C generated a condensed solid state and cooling to 25°C recovered the swollen state. Furthermore, the C-rich sequences provided a cyclic transition between gel-sol state by exploiting alternative pH under acidic (pH 5.2) and basic (pH 7.5) conditions [31]. To illustrate the generality of this design, ssDNAs were conjugated to pNIPAM chains for the specific detection of target molecules.…”

Section: I-motif Structure-based Dna Hydrogelsmentioning

confidence: 99%

DNA hydrogel-empowered biosensing

Khajouei

Ravan

Ebrahimi

2020

Advances in Colloid and Interface Science

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DNA hydrogels as special members in the DNA nanotechnology have provided crucial prerequisites to create innovative gels owing to their sufficient stability, biocompatibility, biodegradability, and tunable multifunctionality. These properties have tailored DNA hydrogels for various applications in drug delivery, tissue engineering, sensors, and cancer therapy. Recently, DNA-based materials have attracted substantial consideration for the exploration of smart hydrogels, in which their properties can change in response to chemical or physical stimuli. In other words, these gels can undergo switchable gel-to-sol or sol-to-gel transitions upon application of different triggers. Moreover, various functional motifs like i-motif structures, antisense DNAs, DNAzymes, and aptamers can be inserted into the polymer network to offer a molecular recognition capability to the complex. In this manuscript, a comprehensive discussion will be endowed with the recognition capability of different kinds of DNA hydrogels and the alternation in physicochemical behaviors upon target introducing. Finally, we offer a vision into the future landscape of DNA based hydrogels in sensing applications.

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Section: I-motif Structure-based Dna Hydrogelsmentioning

confidence: 99%

DNA hydrogel-empowered biosensing

Khajouei

Ravan

Ebrahimi

2020

Advances in Colloid and Interface Science

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“…Shape‐memory polymers represent an interesting class of smart, stimuli‐responsive materials. These polymers are processed into a permanent shaped structure that is programmed into a temporary shape that includes a memory to restore the original shape, in the presence of an appropriate trigger . A variety of triggers such as thermal, light or magnetic stimuli were used to activate shape‐memory materials .…”

Section: Figurementioning

confidence: 99%

A Shape‐Memory DNA‐Based Hydrogel Exhibiting Two Internal Memories

Guo

Kahn

et al. 2016

Angewandte Chemie

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The synthesis of ashape-memory acrylamide-DNA hydrogel that includes two internal memories is introduced. The hydrogel is stabilized, at pH 7.0, by two different pHresponsive oligonucleotide crosslinking units.AtpH10.0, one of the T-A·T triplex DNAb ridging units is dissociated, resulting in the dissociation of the hydrogel into as hapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory.S imilarly,a tp H5.0, the second type of bridges is separated, through the formation of C-G·C + triplex units to yield the shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. By reversible pH triggering of the hydrogel between the values 10.0,7.0,5.0, the two internal memories cycle the material across shaped hydrogel and shapeless quasi-liquid states.T he two memories enable the pH-dictated formation of two different hydrogel structures.The design of stimuli-responsive DNA-based hydrogels attracts substantial recent interest. Thecrosslinking of nucleic acid-tethered polymer chains through the formation of duplex bridging units provides ag eneral means to generate DNAbased hydrogels.[1] Theh ydrogel-to-polymer solution transitions of these systems were induced by strand displacement, [2] temperature, [3] enzyme [3,4] or DNAzyme [5] cleavage of the bridging units.O ther DNA-based hydrogels undergoing cyclic and reversible hydrogel-to-polymer solution included metal-ion (e.g.,A g + )-induced bridging of duplex DNAa nd their separation by ligands eliminating the ions (e.g., cysteamine), [6] the pH-induced formation of i-motif-crosslinked hydrogels (at pH 5.2) and the separation of the i-motif structure at neutral pH, [7] the K + -ion-stimulated crosslinking of polymer chains by G-quadruplex units and the separation of the hydrogel by means of 18-crown-6-ether that eliminates the K + ions, [8] the use of light, [9] and the use of different Hoogsteen-type pH-sensitive triplex DNAa sb ridging units of the polymer chains.[10] Different applications of stimuliresponsive DNA-based hydrogels were suggested, including controlled drug release, [11] sensors, [12] switchable catalysis, [8] and catalyzed synthesis of conducting wires, [13] separation of substrates, [14] and the triggered activation of enzyme cascades. [5] Shape-memory polymers represent an interesting class of smart, stimuli-responsive materials.T hese polymers are processed into ap ermanent shaped structure that is programmed into at emporary shape that includes am emory to restore the original shape,i nt he presence of an appropriate trigger. [2,3,6,8,13a, 15] Avariety of triggers such as thermal, light or magnetic stimuli were used to activate shape-memory materials.[3,9,15f] Different applications of shape-memory materials were suggested, including their use as sensors, functional materials for inscription, [16] matrices for controlled drug release, [17] and materials for actuating microdevices.[18]Thei nformation encoded in oligonucleotide [19] sequences provides versatile means ...

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“…Poly( N ‐isopropylacrylamide) (PNIPAM) hydrogels exhibit a reversible volume phase transition in water from a swollen, hydrophilic state to a deswollen, relatively hydrophobic state when heated above the volume phase transition temperature (VPTT) of PNIPAM (≈32 °C) . PNIPAM hydrogels have widespread applications in the fields of actuators, soft robots, biosensors, drug carriers, tissue engineering scaffolds, etc. For example, controlled drug release can be achieved by changing the temperature to induce the swelling or contraction of PNIPAM hydrogels .…”

Section: Introductionmentioning

confidence: 99%

Near‐Infrared Light‐Triggered Dual Drug Release Using Gold Nanorod‐Embedded Thermosensitive Nanogel‐Crosslinked Hydrogels

Jiang

Wang

Dai

et al. 2019

Macro Materials & Eng

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Gold nanorod (AuNR)‐embedded poly(N‐isopropylacrylamide) (PNIPAM) hydrogels offer the possibility of achieving near‐infrared (NIR) light‐triggered drug release. In addition, using nanoparticles as a crosslinker can enhance the mechanical properties of PNIPAM hydrogels, and nanoparticle‐crosslinked hydrogels provide an important approach for dual drug release. Here, NIR light‐triggered dual drug release using AuNR‐embedded thermosensitive nanogel‐crosslinked hydrogels is reported for the first time. Two kinds of drugs are encapsulated, one in the nanogel and the other in the hydrogel. The volume phase transition of the PNIPAM hydrogels is induced by NIR light by utilizing the photothermal effect of AuNRs. By changing the number of embedded AuNRs and the intensity of NIR light, the release rate and drug quantity can be adjusted for on‐demand release. Because of its NIR light‐triggering and nanoparticle‐crosslinking capabilities, AuNR‐embedded thermosensitive nanogel‐crosslinked hydrogels may expand the application scope of hydrogels and provide enhanced properties in their applications.

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Switchable Bifunctional Stimuli‐Triggered Poly‐N‐Isopropylacrylamide/DNA Hydrogels

Cited by 174 publications

References 60 publications

DNA hydrogel-empowered biosensing

DNA hydrogel-empowered biosensing

A Shape‐Memory DNA‐Based Hydrogel Exhibiting Two Internal Memories

Near‐Infrared Light‐Triggered Dual Drug Release Using Gold Nanorod‐Embedded Thermosensitive Nanogel‐Crosslinked Hydrogels

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