DNA hydrogel-empowered biosensing

Khajouei, Sima; Ravan, Hadi; Ebrahimi, Ali

doi:10.1016/j.cis.2019.102060

Cited by 78 publications

(56 citation statements)

References 84 publications

(94 reference statements)

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“…These designs make advantages of the DNA’s merits can endow the formed hydrogel with high designability and precise controllability ( Shahbazi et al, 2018 ). The presence of functional DNA makes DNA hydrogel a good platform to sensing the external stimuli ( Ma et al, 2017 ; Khajouei et al, 2020 ). However, because of multiple drugs or signal molecules are small molecules, DNA hydrogel networks show high permeability toward them.…”

Section: Classification Of Hydrogelsmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. Hydrogels are categorized by the composition from natural polymers to synthetic polymers. To meet the complicated situation in the biomedical applications, suitable host–guest supramolecular interactions are rationally selected. This review will have an introduction of hydrogel classification based on the formulation molecules, and then a discussion over the rational design of the intelligent hydrogel to the environmental stimuli such as temperature, irradiation, pH, and targeted biomolecules. Further, the applications of rationally designed smart hydrogels in the biomedical field will be presented, such as tissue repair, drug delivery, and cancer therapy. Finally, the perspectives and the challenges of smart hydrogels will be outlined.

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Section: Classification Of Hydrogelsmentioning

confidence: 99%

Rational Design of Smart Hydrogels for Biomedical Applications

Zhang

Huang

2021

Front. Chem.

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“…Molecular biosensing plays a critical role in disease diagnosis, drug monitoring, and toxin detection (Jung et al, 2017; Khajouei et al, 2020; J. Liu, 2011; N. Xu et al, 2020). As aptamers possess heightened specificity, affinity, and stability in comparison to other recognition molecules, they have received tremendous attention for molecular biosensing applications (Fu et al, 2020; J. Liu et al, 2012).…”

Section: Biosensingmentioning

confidence: 99%

“…Molecular biosensing plays a critical role in disease diagnosis, drug monitoring, and toxin detection (Jung et al, 2017;Khajouei et al, 2020;J. Liu, 2011;N.…”

Section: Biosensingmentioning

confidence: 99%

Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing

Abune

Davis

Wang

2021

WIREs Nanomed Nanobiotechnol

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Molecular recognition is essential to the development of biomaterials. Aptamers are a unique class of synthetic ligands interacting with not only their target molecules with high affinities and specificities but also their complementary sequences with high fidelity. Thus, aptamers have recently attracted significant attention in the development of an emerging class of biomaterials, that is, aptamer‐functionalized hydrogels. In this review, we introduce the methods of incorporating aptamers into hydrogels as pendant motifs or crosslinkers. We further introduce the functions of these hydrogels in recognizing proteins, cells, and analytes through four applications including protein delivery, cell capture, regenerative medicine, and molecular biosensing. Notably, as aptamer‐functionalized hydrogels have the characteristics of both aptamers and hydrogels, their potential applications are broad and beyond the scope of this review. This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Emerging Technologies

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“…As well known, many DNA-based hydrogels can respond rapidly to stimuli factors, such as pH, ions, and biomolecules in the external environment, so they are also widely used in the field of the biosensor. The sensing ability of DNA-based hydrogels can be achieved by changing the swelling volume, mechanical properties, crosslinking density, or the readout signal of released substances ( Jonášová and Stokke, 2016 ; Khajouei et al, 2020 ).…”

Section: Biomedical Application Of Dna-based Hydrogelsmentioning

confidence: 99%

Development, Preparation, and Biomedical Applications of DNA-Based Hydrogels

Jian

Luo

et al. 2021

Front. Bioeng. Biotechnol.

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Hydrogels have outstanding research and application prospects in the biomedical field. Among them, the design and preparation of biomedical hydrogels with deoxyribonucleic acid (DNA) as building blocks have attracted increasing research interest. DNA-based hydrogel not only has the skeleton function of hydrogel, but also retains its biological functions, including its excellent selection specificity, structural designability, precise molecular recognition ability, outstanding biocompatibility, and so on. It has shown important application prospects in the biomedical field, such as drug delivery, biosensing, and tissue engineering. In recent years, researchers have made full use of the characteristics of DNA molecules and constructed various pure DNA-based hydrogels with excellent properties through various crosslinking methods. Moreover, via introducing functional molecules or elements, or combining with other functional materials, a variety of multifunctional DNA-based hybrid hydrogels have also been constructed, which expand the breadth and depth of their applications. Here, we described the recent development trend in the area of DNA-based hydrogels and highlighted various preparation methods of DNA-based hydrogels. Representative biomedical applications are also exemplified to show the high performance of DNA-based hydrogels. Meanwhile, the existing problems and prospects are also summarized. This review provided references for the further development of DNA-based hydrogels.

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DNA hydrogel-empowered biosensing

Cited by 78 publications

References 84 publications

Rational Design of Smart Hydrogels for Biomedical Applications

Rational Design of Smart Hydrogels for Biomedical Applications

Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing

Development, Preparation, and Biomedical Applications of DNA-Based Hydrogels

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