Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway

Zhang, Jiyu; Zhang, Liaoyuan; Shi, Hongyan; Feng, Shufeng; Feng, Tingshuai; Chen, Jianfei; Zhang, Xin; Han, Yuru; Li, Jianbo; Wang, Yiming; Ji, Zhaoyang; Jing, Zhaoyang; Liu, Dakai; Da, Shi; Feng, Li

doi:10.1016/j.virol.2021.10.009

Cited by 6 publications

(7 citation statements)

References 52 publications

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“…On account of CP-724714 suppressed SADS-CoV infection in the post-entry stage, we next to explore the relationship of HER2 phosphorylation and SADS-CoV infection in vitro . Previously study illustrated that SADS-CoV induced the activation of Erk ( Zhang et al., 2022 ). In addition, Ras-Raf-Mek-Erk and PI3K-AKT axes are essential intracellular cascades of HER2 phosphorylation activation.…”

Section: Resultsmentioning

confidence: 96%

“…Meanwhile, SADS-CoV infection induced the activation of HER2-mediated signaling pathways for a short duration. Previous report have pointed that inhibition of Erk reduced SADS-CoV replication and MEK inhibitor U0126 exhibited anti -SADS-CoV efficacy in vitro ( Zhang et al., 2022 ). Collectively, HER2-mediated RAS-RAF-MEK-ERK signaling pathway plays crucial roles in SADS-CoV infection.…”

Section: Discussionmentioning

confidence: 94%

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Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro

et al. 2023

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Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 94%

Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro

et al. 2023

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“…This contradiction may be related to differences in p38 inhibitors, and more studies are needed for clarification. In addition, ERK1/2 activation is required for the efficient propagation of SADS-CoV [ 28 ].…”

Section: Important Host Factors Involved In Pecov Replicationmentioning

confidence: 99%

A Review of Bioactive Compounds against Porcine Enteric Coronaviruses

Duan

Luo

Liang

et al. 2022

Viruses

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Pig diarrhea is a universal problem in the process of pig breeding, which seriously affects the development of the pig industry. Porcine enteric coronaviruses (PECoVs) are common pathogens causing diarrhea in pigs, currently including transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV) and swine acute diarrhea syndrome coronavirus (SADS-CoV). With the prosperity of world transportation and trade, the spread of viruses is becoming wider and faster, making it even more necessary to prevent PECoVs. In this paper, the host factors required for the efficient replication of these CoVs and the compounds that exhibit inhibitory effects on them were summarized to promote the development of drugs against PECoVs. This study will be also helpful in discovering general host factors that affect the replication of CoVs and provide references for the prevention and treatment of other CoVs.

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“…U0126 also interferes with the spread of Borna disease virus (BDV) to neighboring cells 83 . Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered enteric coronavirus and treatment of cells with U0126 significantly inhibited SADS-CoV infection 84 . U0126 is not currently approved by the FDA for animal or human use.…”

Section: Drug Enrichment Analysismentioning

confidence: 99%

Modeling COVID-19 disease biology to identify drug treatment candidates

Jessen

Gaisenband

Quintanilla

et al. 2022

Preprint

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Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there are a limited number of effective treatments. A variety of drugs that have been approved for other diseases are being tested for the treatment of COVID-19, and thus far only remdesevir, dexamethasone, baricitinib, tofacitinib, tocilizumab, and sarilumab have been recommended by the National Institutes of Health (NIH) COVID-19 Treatment Guidelines Panel for the therapeutic management of hospitalized adults with COVID-19. Using a disease biology modeling approach, we constructed a protein-protein interactome network based on COVID-19- associated genes/proteins described in research literature together with known protein-protein interactions in epithelial cells. Phenotype and disease enrichment analysis of the COVID-19 disease biology model demonstrated strong statistical enrichments consistent with patients’ clinical presentation. The model was used to interrogate host biological response induced by SARS-CoV-2 and identify COVID-19 drug treatment candidates that may inform on drugs currently being evaluated or provide insight into possible targets for potential new therapeutic agents. We focused on cancer drugs as they are often used to control inflammation, inhibit cell division, and modulate the host microenvironment to control the disease. From the top 30 COVID-19 drug candidates, twelve have a role as an antineoplastic agent, seven of which are approved for human use. Altogether, nearly 40% of the drugs identified by our model have been identified by others for COVID-19 clinical trials. Disease biology modeling incorporating disease-associated genes/proteins discussed in the research literature together with known molecular interactions in relevant cell types is a useful method to better understand disease biology and identify potentially effective therapeutic interventions.

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Swine acute diarrhea syndrome coronavirus replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway

Cited by 6 publications

References 52 publications

Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro

Identification of a receptor tyrosine kinase inhibitor CP-724714 inhibits SADS-CoV related swine diarrhea coronaviruses infection in vitro

A Review of Bioactive Compounds against Porcine Enteric Coronaviruses

Modeling COVID-19 disease biology to identify drug treatment candidates

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