Swimming Training Attenuates Allodynia and Hyperalgesia Induced by Peripheral Nerve Injury in an Adult Male Rat Neuropathic Model: Effects on Irisin and GAD65

Farzad, Babak; Rajabi, Hamid; Gharakhanlou, Reza; Allison, David J.; Hayat, Parisa; Jameie, Seyed Behnamedin

doi:10.1093/pm/pnx294

Cited by 24 publications

(36 citation statements)

References 38 publications

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“…The two species of rats in the included studies were Sprague–Dawley (78.6%) and Wistar rats (21.4%). Only one study (22) (7.1%) used female rats, and 13 studies (12–21, 23–25) (92.9%) used male rats in their experiments. The age of the rats was mentioned in 3 studies (17, 18, 22), which ranged from 6 weeks old to 12 weeks old, and 4 articles (13, 23–25) described as adult rats.…”

Section: Resultsmentioning

confidence: 99%

“…Only one study (22) (7.1%) used female rats, and 13 studies (12–21, 23–25) (92.9%) used male rats in their experiments. The age of the rats was mentioned in 3 studies (17, 18, 22), which ranged from 6 weeks old to 12 weeks old, and 4 articles (13, 23–25) described as adult rats. A total of 12 studies (12–17, 19–21, 23–25) described the weight of rats, which ranged from 180 to 380 g. Three pain models were reported in the different studies, which included SNL (21.4%), CCI (50%), and diabetic neuropathy (28.6%).…”

Section: Resultsmentioning

confidence: 99%

“…Grace et al (18) used voluntary wheel running as exercise form, and the rats in the experimental group were housed with running wheels, whereas control rats were housed with locked wheels. Treadmill running and swimming were the forced exercise training in 10 (13, 14, 16, 17, 19–22, 24, 25) and 2 studies (12, 23), respectively. Only one study (15) used both treadmill running and swimming for the research.…”

Section: Resultsmentioning

confidence: 99%

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Meta-Analysis of the Effect of Exercise on Neuropathic Pain Induced by Peripheral Nerve Injury in Rat Models

et al. 2019

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Background: There is accumulating evidence showing that exercise therapy may play an active role in peripheral neuropathic pain (NP). However, there have been no meta-analysis to investigate the effects of exercise on NP induced by peripheral nerve injury in rat models. Methods: PubMed, EMBASE, and Web of Science were searched from inception to January 2019. A random-effect model was implemented to provide effect estimates for pain-related behavioral test outcome. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Results: Fourteen studies were included. For the mechanical withdrawal threshold, rats in the exercised group exhibited significantly higher thresholds than those in the control group, with a MD of 0.91 (95% CI 0.11–1.71), 3.11 (95% CI 1.56–4.66), 3.48 (95% CI 2.70–4.26), 4.16 (95% CI 2.53–5.79), and 5.58 (95% CI 3.44–7.73) at 1, 2, 3, 4, and 5 weeks, respectively. Additionally, thermal withdrawal latency increased in the exercised group compared with the control group, with a MD of 2.48 (95% CI 0.59–4.38), 3.57 (95% CI 2.10–5.05), 3.92 (95% CI 2.82–5.03), and 2.84 (95% CI 1.29–4.39) at 1, 2, 3, and 4 weeks, respectively. Subgroup analyses were performed for pain models, exercise start point, exercise forms, and duration, which decreased heterogeneity to some extent. Conclusion: This meta-analysis indicated that exercise provoked an increase in mechanical withdrawal threshold and thermal withdrawal latency in animal NP models. Exercise therapy may be a promising non-pharmacologic therapy to prevent the development of NP. Further, preclinical studies focused on improving experiment design and reporting are still needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Meta-Analysis of the Effect of Exercise on Neuropathic Pain Induced by Peripheral Nerve Injury in Rat Models

et al. 2019

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“…In addition, irisin expression is enriched in GABAergic cells [ 65 ], which release gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter, which inhibits neuropathic pain [ 66 , 67 , 68 ]. Exercise increases circulating GABA [ 69 ] and prevents a reduction in the level of glutamate decarboxylase 65, which catalyzes the decarboxylation of glutamate to GABA in the nervous system [ 35 ]. Although several studies have revealed that exercise promotes GABA signaling [ 70 , 71 , 72 ], how irisin regulates the GABA pathway remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Exercise and physical therapy alleviate chronic neuropathic pain by modulating neuroinflammation [ 29 , 30 , 31 , 32 , 33 ]. Irisin has also been suggested to alleviate pain sensitization [ 34 , 35 ] and possess diagnostic value for pain symptoms [ 36 , 37 ]. However, its role in burn-induced neuropathy remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Irisin Gene Delivery Ameliorates Burn-Induced Sensory and Motor Neuropathy

Huang

Yang

et al. 2020

IJMS

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Burn-related neuropathy is common and often involves pain, paresthesia, or muscle weakness. Irisin, an exercise-induced myokine after cleavage from its membrane precursor fibronectin type III domain-containing 5 (FNDC5), exhibits neuroprotective and anti-inflammatory activities. A rat model of third-degree burn on the right hind paw was used to investigate the therapeutic role of irisin/FNDC5. Rats received burn injury and were treated with intrathecal recombinant adenovirus containing the irisin sequence (Ad-irisin) at 3 weeks postburn. One week later, mechanical allodynia was examined. The expression of irisin in cerebrospinal fluid (CSF) was detected. Ipsilateral gastrocnemius muscle and lumbar spinal cord were also obtained for further investigation. Furthermore, the anti-apoptotic effect of recombinant irisin in SH-SY5Y cells was evaluated through tumor necrosis factor alpha (TNFα) stimulus to mimic burn injury. We noted intrathecal Ad-irisin attenuated pain sensitization and gastrocnemius muscle atrophy by modulating the level of irisin in CSF, and the expression of neuronal FNDC5/irisin and TNFα in the spinal cord. Ad-irisin also ameliorated neuronal apoptosis in both dorsal and ventral horns. Furthermore, recombinant irisin attenuated TNFα-induced SH-SY5Y cell apoptosis. In summary, irisin attenuated allodynia and muscle wasting by ameliorating neuroinflammation-induced neuronal apoptosis.

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Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging‐induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats

Zargani

Ramírez‐Campillo

Arabzadeh

2023

Pflugers Arch - Eur J Physiol

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Swimming Training Attenuates Allodynia and Hyperalgesia Induced by Peripheral Nerve Injury in an Adult Male Rat Neuropathic Model: Effects on Irisin and GAD65

Cited by 24 publications

References 38 publications

Meta-Analysis of the Effect of Exercise on Neuropathic Pain Induced by Peripheral Nerve Injury in Rat Models

Meta-Analysis of the Effect of Exercise on Neuropathic Pain Induced by Peripheral Nerve Injury in Rat Models

Irisin Gene Delivery Ameliorates Burn-Induced Sensory and Motor Neuropathy

Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging‐induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats

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