In
the 2000s, nail polish manufacturers started promoting “3-Free”
products, phasing out three widely publicized toxic chemicals: toluene,
formaldehyde, and dibutyl phthalate (DnBP). However, DnBP was
sometimes replaced by another endocrine-disrupting plasticizer,
triphenyl phosphate (TPHP). Many new “n-Free”
labels have since appeared, without any standardization on which n chemicals are excluded. This study aimed to compare measured
plasticizer content against nail polish labels. First, we summarized
definitions of labels. Then, we measured 12 phthalate and 10 organophosphate
plasticizers in 40 nail polishes from 12 brands selected for popularity
and label variety. We found labels ranging from 3- to 13-Free; 10-Free
was the most inconsistently defined (six definitions). Our samples
contained TPHP and bis(2-ethylhexyl) phthalate (DEHP) at up to 7940
and 331 μg/g, respectively. The 5- to 13-Free samples had lower
TPHP levels than unlabeled or 3-Free samples (median <0.002 vs
3730 μg/g, p < 0.001). The samples that
did not contain TPHP had higher DEHP levels (median 68.5 vs 1.51 μg/g, p < 0.05). We measured plasticizers above 100 μg/g
in five brands that did not disclose them and in two that excluded
them in labels. This study highlights inconsistencies in nail polish
labels and identifies TPHP and DEHP as ingredient substitutes for
DnBP.