Swept-Source Optical Coherence Tomography Angiography of the Optic Disk in Optic Neuropathy

Falavarjani, Khalil Ghasemi; Tian, Jun-Ru; Akıl, Handan; Garcia, Giancarlo A.; Sadda, Srinivas R; Sadun, Alfredo A.

doi:10.1097/iae.0000000000001259

Cited by 96 publications

(85 citation statements)

References 12 publications

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“…Previous FA studies in NAION have shown significant delay in the filling of the ONH capillaries, but normal choroidal perfusion 7. A recent study has evaluated the ONH microvasculature in acute and chronic optic neuropathies of various causes, using swept-source OCT-A, showing less visible and more tortuous peripapillary and prelaminar microvessels, in affected eyes 16. Our study suggests reduced flow density in acute NAION eyes, when measured within the combined retina and choroid, as well as within the choroid alone.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy

et al. 2017

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“…Decreased peripapillary capillary loss was also recently been demonstrated in a few cases of NAION by others. 11,12 However, the location of ischaemia in anterior ischaemic optic neuropathy is thought to occur in the optic nerve head, with the circulation derived from the posterior ciliary arteries, and not in the superficial peripapillary retinal capillary plexus, which is derived from the branches of the central retinal artery. Other causes of optic neuropathy, such as optic neuritis and trauma, are not thought to have ischaemia as an underlying cause of the disease process, and these cases also showed similar loss of the peripapillary vessel density on OCT angiography in our series.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies

Chen

AbouChehade

Iezzi

et al. 2017

Neuro-Ophthalmology

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Glaucoma causes a decrease in peripapillary perfused capillary density on optical coherence tomography (OCT) angiography. However, other chronic optic neuropathies have not been explored with OCT angiography to see if these changes were specific to glaucoma. The authors evaluated OCT angiography in 10 patients who suffered various kinds of chronic optic neuropathies, including optic neuritis and ischaemic optic neuropathy, and found that all optic neuropathies showed a decrease in peripapillary vessel density on OCT angiography, regardless of the aetiology of the optic neuropathy. The peripapillary vessel loss on OCT angiography correlated well with the areas of retinal nerve fibre layer thinning seen on OCT.ARTICLE HISTORY

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“…OCT angiography is a new imaging modality that provides non-invasive high resolution images of the optic nerve and retinal vessels 25 . The influence of MRNF on retinal vessel density measurement with OCT angiography has been previously reported in two cases of focal MRNF 26 .…”

Section: Discussionmentioning

confidence: 99%

Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers

Garcia

Tian

Apinyawasisuk

et al. 2016

Journal of Current Ophthalmology

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PurposeWe present a case of bilateral extensive peripapillary myelinated retinal nerve fibers (MRNF) in an individual with Crouzon syndrome, an inherited form of craniosynostosis caused by overactivation of fibroblast growth factor receptor 2. As a secondary aim, we examine the utility of optical coherence tomography (OCT) angiography for visualization of peripapillary vasculature obscured by myelination on other imaging modalities.MethodsA 24-year-old woman with Crouzon syndrome was evaluated for suspected optic neuritis in the right eye.ResultsFunduscopic examination and photography revealed the incidental finding of bilateral extensive peripapillary MRNF. OCT angiography provided excellent visualization of peripapillary retinal vessels, which were partially obscured by myelination on other imaging modalities.ConclusionsThis association of Crouzon syndrome with bilateral peripapillary MRNF may lend insight into the developmental control of optic nerve myelination, the pathogenesis of MRNF, and the potential role of growth factors in these processes. Further, OCT angiography allowed for excellent blood vessel visualization in this case of MRNF.

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Swept-Source Optical Coherence Tomography Angiography of the Optic Disk in Optic Neuropathy

Abstract: Optical coherence tomography angiography provides high-resolution, noninvasive visualization of the microvasculature of the optic nerve head and peripapillary region. Changes in the microvasculature in this region may prove useful in better characterization of optic neuropathies.

Cited by 96 publications

References 12 publications

Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy

Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy

Optical Coherence Angiographic Demonstration of Retinal Changes From Chronic Optic Neuropathies

Clues from Crouzon: Insights into the potential role of growth factors in the pathogenesis of myelinated retinal nerve fibers

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