Swelling, mechanical and mucoadhesion properties of Mt/starch-g-PMAA nanocomposite hydrogels

Güler, Mehmet Ali; Gök, Mehmet Koray; Fıgen, Aysel Kantürk; Özgümüş, Saadet

doi:10.1016/j.clay.2015.04.019

Cited by 58 publications

(25 citation statements)

References 98 publications

(126 reference statements)

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“…This effect prevented recrystallization of starch, caused by the bulky side group of the grafted chains . This result supported that MAM monomers were successfully grafted onto starch backbones and agreed with the decrease in crystalline intensity peaks in the X‐ray diffractograms and the formation of amorphous material in starch hydrogel grafted with MAA …”

Section: Resultssupporting

confidence: 77%

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Effects of Polymethacrylamide‐Grafted Branch on Mechanical Performances, Hydrophilicity, and Biodegradability of Thermoplastic Starch Film

Weerapoprasit

Prachayawarakorn

2019

Starch Stärke

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To overcome the shortcomings of brittleness and high water uptake of thermoplastic native starch (TPNS) film, thermoplastic-grafted starch (TPGS) film is prepared and tested using starch-g-polymethacrylamide (PMAM) with different percentages of grafting. Starch-g-PMAM is compounded in an internal mixer and then shaped by a compression molding machine to produce a TPGS film. Functional group analysis by Fourier transform infrared spectroscopy (FTIR) revealed that the graft copolymerization is successful, as evident from new characteristic infrared (IR) peaks of amide group (C═O stretching and N─H bending). TPGS films with MAM has more surface roughness than TPNS film does. With higher grafting percentages, the degrees of crystallinity and hydrophilicity of TPGS film reduce while the extensibility (based on strain at maximum load) and surface roughness increase, compared to that at lower percentages of grafting. The biodegradability of TPGS films grafted with MAM at different percentages is also examined.

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Section: Resultssupporting

confidence: 77%

“…In the same way, Celik and Guler et al. reported that a rough morphology of starch‐ g ‐PMAM was observed after a grafting reaction . This observation confirmed that MAM monomers were successfully grafted onto the starch chains.…”

Section: Resultssupporting

confidence: 65%

Effects of Polymethacrylamide‐Grafted Branch on Mechanical Performances, Hydrophilicity, and Biodegradability of Thermoplastic Starch Film

Weerapoprasit

Prachayawarakorn

2019

Starch Stärke

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“…After incubation that ensures full contact between the formulation and the mucus, the mucoadhesive strength is measured as the force of detachment. Formulations such as tablets, films, hydrogels, and fibers can be studied using this technique.…”

Section: Methods For Macroscale Testing Of Mucoadhesionmentioning

confidence: 99%

Innovative Methods and Applications in Mucoadhesion Research

Mackie

Goycoolea

Menchicchi

et al. 2017

Macromolecular Bioscience

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The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described.

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“…It can be noticed that the addition of inorganic filler increased the storage modulus when frequency was increased for all types of clay. This phenomenon could be related to strong interactions between the hydrogel and high aspect ratio clay platelets, as mentioned by other groups [ 53 , 54 , 55 ]. The storage modulus results showed that among the nanocomposite hydrogels, PMAA-Cl 93A-C18 had the highest value with increasing frequency, for all cycles registered.…”

Section: Resultsmentioning

confidence: 70%

Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

et al. 2017

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Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding. This will create the premises to obtain nanocomposite hydrogels with combined hydrophilic-hydrophobic behavior absolutely necessary for co-delivery of polar/nonpolar substances. For the synthesis, N,N’-methylenebisacrylamide was used as cross-linker and ammonium persulphate as initiator. As a consequence of the inclusion of clay into the polymer matrix and the intercalation of PMAA between the layers as well as the presence of hydrophobic interactions occurred between partners, the final hydrogel nanocomposites possessed greater swelling degrees, slower de-swelling process and enhanced mechanical properties depending on the clay type in comparison with pure hydrogel. In vitro MTS ([3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt]) colorimetric assay showed that direct exposure with PMMA-clay-based constructs did not affect cell viability and proliferation in time (24 and 48 h) on either normal or adenocarcinoma cell lines.

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Swelling, mechanical and mucoadhesion properties of Mt/starch-g-PMAA nanocomposite hydrogels

Cited by 58 publications

References 98 publications

Effects of Polymethacrylamide‐Grafted Branch on Mechanical Performances, Hydrophilicity, and Biodegradability of Thermoplastic Starch Film

Effects of Polymethacrylamide‐Grafted Branch on Mechanical Performances, Hydrophilicity, and Biodegradability of Thermoplastic Starch Film

Innovative Methods and Applications in Mucoadhesion Research

Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

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