Novel Hydrogel-Advanced Modified Clay Nanocomposites as Possible Vehicles for Drug Delivery and Controlled Release

Abstract

Present study refers to the synthesis of new advanced materials based on poly(methacrylic acid) (PMAA) with previously reported own advanced modified clays by edge covalent bonding. This will create the premises to obtain nanocomposite hydrogels with combined hydrophilic-hydrophobic behavior absolutely necessary for co-delivery of polar/nonpolar substances. For the synthesis, N,N’-methylenebisacrylamide was used as cross-linker and ammonium persulphate as initiator. As a consequence of the inclusion of clay into the polymer matrix and the intercalation of PMAA between the layers as well as the presence of hydrophobic interactions occurred between partners, the final hydrogel nanocomposites possessed greater swelling degrees, slower de-swelling process and enhanced mechanical properties depending on the clay type in comparison with pure hydrogel. In vitro MTS ([3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt]) colorimetric assay showed that direct exposure with PMMA-clay-based constructs did not affect cell viability and proliferation in time (24 and 48 h) on either normal or adenocarcinoma cell lines.

Assessment of Naturally Sourced Mineral Clays for the 3D Printing of Biopolymer-Based Nanocomposite Inks

“…In this respect, nanoclays can be functionalized with hydrophobic compounds. By organomodification, clay nanoplatelets became amphiphilic and thus compatible with the polymer matrices also acting as delivery vehicles for several organic molecules [ 50 , 52 , 53 , 54 , 55 , 56 ]. Additionally, clays are osteoinductive silica-rich inorganic species and, when investigated for skeletal regeneration, were shown to promote osteogenic differentiation and increased network stiffness and porosity [ 46 , 47 , 48 ].…”

Composite Hydrogels Based on Poly (Methacrilyc Acid) Reinforced with Laponite Inorganic Filler

“…The rheological measurements proved that both storage and loss moduli increased with Laponite concentrations. The FTIR and XRD analyses confirmed the incorporation of the clay into the poly(methacrylic acid) hydrogel matrix and also the interactions between the inorganic filler and the polymer chain [1]. The swelling degree was influenced by the amount of Laponite incorporated into the polymer matrix.…”

Interaksi Molekuler Amonium Hidroksida

“…Antara NH4 + dan OHberikan ion (115,118,(130)(131)(132)(133)(134)(135) . Sedangkan atom-atom dalam NH4OH berikatan kovalen (136)(137)(138)(139)(140)(141)(142)(143)(144)(145) .Ketika NH4 + direaksikan dengan OH -, maka senyawa NH4 + akan menarik elektron dari OH -. Dengan demikian, akibat adanya perbedaan muatan dari ion-ion NH4OH mengakibatkan ion-ion tersebut tarik-menarik sehinggak membentuk senyawa NH4OH.…”