Swelling Kinetics of Interpenetrating Polymer Hydrogels Composed of Poly(Vinyl Alcohol)/Chitosan

Kim, Seon Jeong; Lee, Ki Jung; Kim, In Young; Kim, Sun I.

doi:10.1081/ma-120019888

Cited by 32 publications

(9 citation statements)

References 19 publications

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“…It was found that the amounts of water retention of chitosan/gelatin membranes increased as the ratio of proportion of gelatin in the mixtures increased. This implies that increased proportion of chitosan in chitosan/gelatin membranes made the materials stable in sizes and shapes 5, 15, 31. Stability tests showed the crosslinked films (GA or PA) produced noticeable increases in the stability in the water at both of pH 4 and pH 7, as well as decreased swellibility 17, 24, 30, 32.…”

Section: Discussionmentioning

confidence: 99%

Chitosan/gelatin–based films crosslinked by proanthocyanidin

et al. 2005

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Novel polymer networks consisting of crosslinked gelatin/chitosan were prepared by a solution casting technique. Methods for bulk crosslinking were developed to modify the gelatin/chitosan blends with the use of a nontoxic crosslinking reagent, proanthocyanidin (PA). FTIR spectral analyses of the preparations showed network formations of crosslinked gelatin, chitosan, and PA by amide and ester linkages. The crosslinked networks were stable in the aqueous state, and had improved mechanical properties and thermal stability when compared with nonlinked gelatin (G) and chitosan/gelatin (C/G) films. In vitro protease digestion and cell-culture studies showed that the PA-crosslinked C/G films are nontoxic and exhibited decreased biodegradation rate and a better ability to support cell adhesion and proliferation than noncrosslinked gelatin or chitosan alone. These results suggest that such a nontoxic crosslinked gelatin/chitosan scaffold can become a promising matrix for tissue-engineering applications.

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Section: Discussionmentioning

confidence: 99%

Chitosan/gelatin–based films crosslinked by proanthocyanidin

et al. 2005

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“…CS hydrogels are very fragile and can be improved through the incorporation of other monomers and polymers and/or by crosslinking 15–18. CS/poly(vinyl alcohol) PVA hydrogels have been prepared and have exhibited high swelling in the acidic pH range and low swelling in the basic pH range 19–21. For drug‐delivery applications, these hydrogels need modification because they are not suitable for gastrointestinal delivery because there is a need for negligible drug release at acidic pH (stomach) and controlled release at neutral pH (intestinal).…”

Section: Introductionmentioning

confidence: 99%

Controlled release of aspirin from pH‐sensitive chitosan/poly(vinyl alcohol) hydrogel

Islam

Yasin

Bano

et al. 2011

J of Applied Polymer Sci

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The aim of this study was to develop a cheap, pH-sensitive enteric coating of aspirin with biocompatible polymers. A novel approach was used to develop enteric coating from chitosan (CS) and poly(vinyl alcohol) (PVA). Solutions of CS and PVA (5 : 1 mol ratio) were mixed and selectively crosslinked with tetraethoxysilane. IR analysis confirmed the presence of the incorporated components and the existence of siloxane linkages between CS and PVA. The crosslinking percentage and thermal stability increased with increasing amount of crosslinker. The response of the developed coating in different media, such as water, pH (nonbuffer and buffer), and ionic media showed hydrogel properties. All hydrogels showed low swelling in acidic and basic pH media, whereas maximum swelling was exhibited at neutral pH. This pH sensitivity of the hydrogel has been exploited as enteric coating for commercial aspirin tablets. The dissolution test of enteric-coated aspirin tablet in simulated gastric fluid (pH 1.2) showed 7.11% aspirin release over a period of 2 h, whereas a sustained release of remaining aspirin (83.25%) was observed in simulated intestinal fluid (pH 6.8). V C 2011 Wiley Periodicals, Inc. J Appl Polym Sci 124: [4184][4185][4186][4187][4188][4189][4190][4191][4192] 2012

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“…It reveals that 85.5% drug was released in 7.5 h that was in accordance with the US pharmacopeia standards. 26 Moreover, the remaining amount could not be determined because the hydrogel was broken down into fragments. The synthesized hydrogel covered the property of the controlled drug release.…”

Section: Drug Release Analysismentioning

confidence: 99%

“…23 The polymeric blends of synthetic and biopolymers have been reported having maximum swelling at low pH. [24][25][26][27] Furthermore, such compositions cannot be used in gastric drug delivery. However, we developed hydrogels that showed high swelling at pH 8.…”

Section: Introductionmentioning

confidence: 99%