Sweetened beverages intake, hyperuricemia and metabolic syndrome. The Mexico City Diabetes Study

Abstract

Objective. To determine prevalence of hyperuricemia and its relation with intake of sweetened beverages (SB) and metabolic syndrome (MS) in low income urban Mexican population. aterials and methods. A cross-sectional analysis of The Mexico City Diabetes Study, a prospective population-based investigation (1 173 participants) was performed. We used logistic egression, adjusted by pertinent variables. We determined prevalence of hyperuricemia and explored associations of uric acid levels with MS and intake of SB. Results. Prevalence of hyperuricemia was 26.5 and 19.8% in males and females respectively. In an djusted multivariate model, body mass index, waist circumference,and triglyceride were higher as uric acid quartiles increased (p<0.005-0.001). The odds ratio for MS was 1.48 for 3rd uric acid quartile and 2.03 for 4th quartile. Higher consumption of SB was associated with higher uric acid levels (p<0.001). Conclusion. Prevalence of hyperuricemia is high. Potential association with intake of SB, resulting in metabolic altera- tions should be considered.

Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans

“…This study examined the risk factors for hyperuricemia in a cohort with a high proportion of obesity and metabolic syndrome and in two obesity case-control studies. The prevalence of hyperuricemia in these groups was similar to other studies with metabolically compromised subjects [5,39,40,41]. A previous study of hypertensive Europeans reported a lower prevalence of hyperuricemia (17%) [5], in contrast with our results and those of another study in a European population that also observed a higher prevalence of hyperuricemia (29% and 25%, respectively) [40].…”

“…The results in our study have the same direction as previous reports; however, a larger effect was observed in children and adult women from the case-control study. Additionally, the well-known association between hyperuricemia and metabolic syndrome was also observed [39,45,46,47,48] in this study, particularly among girls and adult women from the case-control study. However, it is important to note that these women are younger and have a different menopausal status, compared to the older female participants from the HWCS.…”

“…The Mexican population is one of the highest consumers of soft drinks, and the association between soft drink consumption and hyperuricemia is known [9,39]. A positive association between sweetened beverages and hyperuricemia, after adjusting for total calorie intake, was reported from data obtained as part of the 2004–2006 assessment of the HWCS [9].…”

Positively increased visceral adiposity index in hyperuricemia free of metabolic syndrome

“…As is known dyslipidemia was the basic of VAI increase. One Mexican population study revealed that sweetened beverages intake increased the risk of hyperuricemia and obesity [ 34 ]. Maybe keep fit and diet control was helpful for visceral obesity, specially in Chinese males, since Chinese individuals had the most deleterious abdominal visceral fat distribution and accumulation other than Europeans at a given BMI or WC [ 35 ].…”

Hyperuricemia on Admission Predicts Short-Term Mortality due to Myocardial Infarction in a Population with High Prevalence of Cardiovascular Risk Factors

“…In fact, 7/10 adult Mexicans were overweight or obese, 3/10 were hypertensive, and 1/10 were diabetic [3][4][5] . In addition, the Mexico City Diabetes Study, a prospective population-based cohort that included 1,173 participants, reported a prevalence of 26.5 and 19.5% for asymptomatic hyperuricemia in men and women, respectively 6 . Furthermore, this condition was an undiagnosed characteristic in the majority of these individuals.…”