Sweet syndrome associated with intrahepatic cholangiocarcinoma producing granulocyte colony-stimulating factor

Abstract

5 Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med 2003; 139:683-93. 6 Mashiah J, Brenner S. A systemic reaction to patch testing for the evaluation of acute generalized exanthematous pustulosis. Arch Dermatol 2003; 139:1181-83. 7 Schmid S, Kuechler PC, Britschgi M et al. Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation. Am J Pathol 2002; 161:2079-86. 8 Sidoroff A, Halevy S, Bavinck JAB et al. Acute generalized exanthematous pustulosis (AGEP)-a clinical reaction pattern. Conflicts of interest: none declared.(a) Fig 2. (a) Abdominal contrast computed tomography showing a lowdensity 6 cm mass in segment 5 of the liver and a high-density 2 cm mass in the neck of the gallbladder. (b) The tumour cells and the surrounding matrix showed positive immunohistochemical staining for granulocyte colony-stimulating factor (original magnification ·25).

Intrahepatic cholangiocarcinoma: Epidemiology, risk factors, diagnosis and surgical management

“…While a considerable number of patients are asymptomatic, with the lesions detected incidentally during radiologic examinations [43] . Paraneoplastic syndromes are rare findings of patients with ICC, which may present with cutaneous findings such as Sweet syndrome [44] and acanthosis nigricans [45] .…”

Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

“…Subcutaneous Sweet's syndrome is characterized by skin lesions which usually present as erythematous, tender dermal nodules on the extremities [4,8,12,17,99,119,164-185,397]. The lesions often mimic erythema nodosum when they are located on the legs [170].…”

“…For example, exocytosis of neutrophils into the overlying epidermis has been observed as either neutrophilic spongiotic vesicles [194] or subcorneal pustules [12,80,167,195,196]. The condition is referred to as "subcutaneous Sweet's syndrome" when the neutrophils are located either entirely or only partially in the subcutaneous fat [4,8,12,17,99,119,164-184,397,399,417]. …”

Acute promyelocytic leukemia‐associated Sweet's syndrome mimicking an axillary abscess: A case report with review of literature

“…22 (4) Genetic. Two patients of MDS associated SS were recently reported to have heterozygous mutations in MEFV gene (familial Mediterranean fever gene).…”