Sweet's syndrome on the area of postmastectomy lymphoedema

García-Río, Irene; Pérez‐Gala, S.; Aragüés, Maximiliano; Fernández‐Herrera, Jesús; Fraga, Javier; García‐Diez, Amaro

doi:10.1111/j.1468-3083.2006.01460.x

Cited by 27 publications

(33 citation statements)

References 19 publications

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“…14,16 There have also been some recent, less wellknown reports of Sweetís syndrome in areas of postlymphadenectomy lymphedema in patients mastectomized following breast cancer. 17,18 According to Gille and Woodrow, there are no well-established criteria to In the present sample, however, pain (18.5%), relapses (12.7%) and lesions of the oral mucosa (3%) were not associated with malignancy.…”

Section: Discussionmentioning

confidence: 78%

Síndrome de Sweet: estudo de 73 casos, com ênfase nos achados histopatológicos

Rochael

Pantaleão

Vilar

et al. 2011

An. Bras. Dermatol.

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BACKGROUND: Sweet's syndrome refers to a set of cutaneous, systemic and histopathological alterations that occur in response to different stimuli, in a similar way to that occurring in erythema nodosum, erythema multiforme and leukocytoclastic vasculitis. The syndrome has been described in association with conditions such as infections, pregnancy, the use of certain medications and malignancy. OBJECTIVES: To evaluate the clinical and histopathological alterations occurring in this syndrome and to assess the association between these alterations and other conditions. METHODS: A retrospective study of 73 cases was conducted, evaluating data on the microscopic examination of skin lesions, as well as clinical and laboratory data. RESULTS: The majority of the patients were female (83.0%), white (49.2%) and between 30 and 60 years of age (73.8%). The principal alterations found were: erythymatous plaques (76.9%), papules (43.0%), pseudo-vesiculation (PV) (38.4%) and target lesions (18.5%). With respect to the associated conditions, upper respiratory tract infections (15.4%) and the use of medication (10.8%) were the most common. Other associations, albeit represented by only one case each, were: Hodgkin's lymphoma, pregnancy, ulcerative colitis, polycythemia vera and lupus erythematosus in a patient with acquired immune deficiency syndrome (AIDS). The principal microscopic findings were: neutrophils with leukocytoclasia (98.6%), collagen degeneration (87.7%), edema (74.0%) and PV (38.4%). The presence of eosinophils (41.1%) ranged from rare to abundant and was usually unrelated to the use of medication. Inflammatory infiltrate reached the deep epidermal layer in 47.9% of cases and panniculitis was found in 80.0% of cases in which the hypodermis was affected (10 cases). CONCLUSIONS: In general, these findings are in agreement with results published in the literature, emphasizing the frequent finding of eosinophils unrelated to drug use, panniculitis and the rare association with Hodgkin's lymphoma. This is the fifth report of an association between Sweet's syndrome and Hodgkin's disease. Keywords: Erythema Multiforme; Hodgkin's Disease; Panniculitis; Sweet's Syndrome.Resumo: FUNDAMENTOS: A síndrome de Sweet corresponde a um conjunto de alterações cutâneas, sistêmicas e histopatológicas como resposta a diversos estímulos, semelhantes ao eritema nodoso, ao eritema multiforme e à vasculite leucocitoclásica. São descritas condições associadas como infecção, gravidez, uso de drogas e malignidades. OBJETIVOS: Avaliar as alterações clínicas e histopatológicas da síndrome, relacionando-a a outras condições. MÉTODO: Estudo retrospectivo de 73 casos com avaliação microscópica de lesões cutâneas, dados clínicos e laboratoriais. RESULTADOS: Houve predomínio de mulheres (83,0%), brancas (49,2%), entre a quarta e a sexta décadas de vida (73,8%). Placas eritematosas (76,9%), pápulas (43,0%), pseudovesiculação (PV) (38,4%) e lesões em alvo (18,5%) foram as principais alterações. Entre as condições associadas, infecções de vi...

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Section: Discussionmentioning

confidence: 78%

Síndrome de Sweet: estudo de 73 casos, com ênfase nos achados histopatológicos

Rochael

Pantaleão

Vilar

et al. 2011

An. Bras. Dermatol.

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“…Some cases of Sweet's syndrome in the area of postmastectomy lymphedema have also been reported 10 , and most patients were treated by mastectomy with concurrent chemotherapy and radiotherapy. The pathophysiology of this lesion remains unknown, but inadequate lymphatic drainage may disrupt the regularity of cell trafficking.…”

Section: Discussionmentioning

confidence: 99%

Localized Sweet's Syndrome in an Irradiated Field

Lee

Kim

et al. 2009

Ann Dermatol

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“…Lesions have also been photodistributed (Figures 3a and 3b) or localized to the site of a prior phototoxic reaction (sunburn) in some Sweet's syndrome patients [13,20,98,143-145]. Occasionally, Sweet's syndrome lesions have appeared on the arm affected by postmastectomy lymphedema [100,146,414]. …”

Section: Clinical Descriptionmentioning

confidence: 99%