Sweet's syndrome induced by granulocyte colony-stimulating factor in a woman with congenital neutropenia

Diazepam‐associated Sweet's syndrome

“…SS has been understood as a direct response to mechanical and chemical irritants, as an infectious disease, or as a disorder of neutrophilic chemotaxis and/or phagocytosis, but often it has been described as a hypersensitivity reaction. 2–15 In this sense, histologic, immunohistochemical and immunofluorescence microscopy studies have supported a type III hypersensitivity reaction and a T cell‐dependent cellular immune reaction 11–19 . 23 Among those drug‐induced cases reported in the literature, the average time from the initiation of drug therapy to the onset of clinical symptoms, is found to be around 7.5 days.…”

“… 1 It is an uncommon acute disorder frequently associated with a great variety of diseases, such us underlying malignancies (mainly hematological), autoimmune and inflammatory disorders, previous respiratory or gastrointestinal infections and pregnancy 2,3 . Infrequently, it has been also atributed to medications, including trimethoprim‐sulfamethoxazole, 4 minocycline, 5,6 oral contraceptives, 7 all‐ trans‐ retinoic acid, 8,9 , 10 granulocyte colony‐stimulating factor, 11,12 , 13,14 furosemide, 15 hydralazine, 16 lithium, 17 diclofenac, 18 and nitrofurantoine. 19…”

Unusual Annular Erythema Associated with Myelodysplastic Syndrome

“…Several cases of Sweet’s syndrome during or following G-CSF therapy have been reported [10]. The association between G-CSF therapy and Sweet’s syndrome is interesting in that G-CSF acts primarily to stimulate neutrophils, which constitute the dermal infiltrates seen in Sweet’s syndrome.…”

A case of Sweet's syndrome following septic pulmonary emboli after high‐dose chemotherapy for advanced testicular cancer

“…Recently, there have been several reports of Sweet's syndrome most probably related to the administration of G-CSF for neutropenia. 1 As G-CSF is frequently used for neutropenia caused by chemotherapy for urological malignancy, this disease might be on the increase.…”

“…Recently, there have been several reports of Sweet's syndrome in patients with G-CSF administration for MDS. 1 Another study reported that the patient with Sweet's syndrome showed a marked elevation of serum G-CSF, paralleling the extent of the disease. Thus, G-CSF appears to be associated with the onset of Sweet's syndrome, although the exact mechanism is still unknown.…”