Sweet's Syndrome

Herbert-Cohen, Daniel; Jour, George; Saul, Turandot

doi:10.1016/j.jemermed.2015.02.039

Cited by 2 publications

(3 citation statements)

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“…It can also be secondary to a range of systemic factors, including drug exposure, infection and inflammation . The characteristic lesions are typically violaceous or erythematous papules or nodules, usually in the upper limb or face, and with significant dermal oedema , a presentation that is not too dissimilar to that of our own patient (Figure ). Histologically, there is neutrophilic infiltration in the dermis in addition to leukocytoclastic nuclear debris.…”

Section: Discussionmentioning

confidence: 68%

“…Sweet's syndrome, another type of rare dermatosis, was considered in our differential. Similar to LCV, it is an acute neutrophil‐mediated hypersensitivity process that is classically idiopathic . It can also be secondary to a range of systemic factors, including drug exposure, infection and inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…Although LCV can occur as a result of malignancy, it is a rare cause, accounting for less than 1% of cases, and typically tends to occur concurrently with solid tumours or haematological malignancies . LCV associated with the Koebner phenomenon has been described previously , including the development of lesions at a previous skin graft donor site . The only patient‐reported association is previous trauma to the dorsum of his hand, but there are no reports in the literature of trauma‐associated LCV.…”

Section: Discussionmentioning

confidence: 99%

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A not‐so‐sweet diagnosis – leukocytoclastic vasculitis masquerading as squamous cell carcinoma

Mensa

Jessop

Wilson-Jones

et al. 2016

International Wound Journal

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Leukocytoclastic vasculitis (LCV) is a rare small-vessel vasculitis characterised by neutrophilic inflammation of post-capillary venules. Incidence varies from 3 to 4.5 per 100 000 people per year. Patients typically present with painful, itchy purpura and erythema, although clinical manifestations can vary making diagnosis a challenge. We report the case of a 75-year-old man with a history of a previously completely excised and grafted squamous cell carcinoma (SCC) on the dorsum of his hand, who presented with an acutely swollen, erythematous and ulcerated lesion adjacent to the graft site. A shave biopsy failed to definitively exclude SCC recurrence. He was referred to the Plastics team who initially suspected Sweet's syndrome but could not rule out SCC recurrence. The patient underwent formal mapping incisional biopsies that later diagnosed LCV. He was managed conservatively and made an excellent recovery. We present clinical photographs and histology to illustrate disease progression. LCV is typically self-limiting with a good overall prognosis, but a minority of patients follow a protracted course, which may require treatment in the form of systemic corticosteroids or colchicine. LCV can only be confirmed histologically. We present this case in order to highlight the importance of adequate tissue biopsy when there is diagnostic uncertainty with an acute dermatosis, particularly in the context of previous skin malignancy.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%