Sweet liking in patients with Parkinson's disease

Sienkiewicz-Jarosz, Halina; Ścińska, Anna; Święcicki, Łukasz; Lipczyńska-Łojkowska, Wanda; Kuran, W; Ryglewicz, Danuta; Kołaczkowski, Marcin; Samochowiec, Jerzy; Bieńkowski, Przemysław

doi:10.1016/j.jns.2013.03.005

Cited by 84 publications

(29 citation statements)

References 57 publications

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“…Surprisingly, the PD patients rated, on average, a 0.025 % concentration of quinine as more intense than did the controls (p \ 0.04) and exhibited lower electrical taste thresholds (p \ 0.001). Although a subsequent study of 20 PD patients and 20 age-matched controls by this group did not replicate the electrogustometric finding, a 1 % solution of sucrose presented by syringe to the anterior tongue was rated as more intense by the PD patients than by the controls [10]. No influences of PD on whole-mouth pleasantness ratings of sucrose solutions were observed in this study.…”

Section: Introductioncontrasting

confidence: 68%

“…In one study, Sienkiewicz-Jarosz and associates found that PD patients gave larger intensity ratings than did controls to a low concentration of the bitter tasting agent quinine (0.025 %) presented to the anterior tongue on filter paper strips [9]. In a subsequent study, they observed a similar phenomenon for a 1 % concentration of sucrose presented by syringe to the anterior tongue [10]. Although the PD patients of their first study exhibited lower electrical taste thresholds than controls on the anterior tongue, this finding was not replicated by them in their latter study, in accord with our negative finding on this point.…”

Section: Discussionmentioning

confidence: 88%

“…While, as noted above, most studies have found no threshold deficits in electrical thresholds of PD patients [10] or lower thresholds in PD patients than in controls [9], one study of 75 PD patients and 74 ageand sex-matched healthy controls found significant deficits in PD patients on both anterior (CN VII) and posterior (CN IX) regions of the tongue [16]. As in our study, no influences of PD-related drug therapy were evident, although they did find that women had significantly lower thresholds than men on the anterior tongue and a trend towards this on the posterior tongue.…”

Section: Discussionmentioning

confidence: 89%

“…Moberg et al [13] found PD patients less likely to detect the bitter taste of PTC; in general, persons who are insensitive to PTC and related compounds are also less sensitive to NaCl [25,26]. It is of interest that the two stimuli reported by Sienkiewicz-Jarosz et al [9,10] to be more intense for PD patients were quinine and sucrose. It would appear that the basis for such taste-specific differences among studies cannot be readily explained on the basis of differing transduction mechanisms, since sucrose and caffeine depend upon G-protein coupled metabotropic receptors [29][30][31], whereas sodium chloride, citric acid, and quinine mainly depend upon ionotropic receptors (e.g., in the case of sodium chloride, the amiloride-sensitive Na ?…”

Section: Discussionmentioning

confidence: 98%

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Taste function in early stage treated and untreated Parkinson’s disease

et al. 2014

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Since brain stem regions associated with early Parkinson's disease (PD) pathology encroach upon those involved in taste function, the ability to taste may be compromised in PD. However, studies on this point have been contradictory. We administered well-validated whole-mouth and regional taste tests that incorporated multiple concentrations of sucrose, citric acid, caffeine, and sodium chloride to 29 early stage PD patients and 29 age-, sex-, and race-matched controls. Electrogustometry was also performed on the anterior tongue. The PD cohort was tested both on and off dopamine-related medications in counterbalanced test sessions. While whole-mouth taste identification test scores for all stimuli were, on average, nominally lower for the PD patients than for the controls, a trend in the opposite direction was noted for the intensity ratings at the lower stimulus concentrations for all stimuli except caffeine. Moreover, regional testing found that PD subjects tended to rate the stimuli, relative to the controls, as more intense on the anterior tongue and less intense on the posterior tongue. No significant associations were evident between taste test scores and UPDRS scores, L-DOPA medication equivalency values, or [(99m)Tc]TRODAT-1 SPECT imaging of dopamine transporter uptake within the striatum and associated regions. Our findings suggest that suprathreshold measures of taste function are influenced by PD and that this disease differentially influences taste function on anterior (CN VII) and posterior (CN IX) tongue regions. Conceivably PD-related damage to CN IX releases central inhibition on CN VII at the level of the brainstem, resulting in enhanced taste intensity on the anterior tongue.

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Section: Introductioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

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Taste function in early stage treated and untreated Parkinson’s disease

et al. 2014

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“…Hedonicity of taste was also evaluated, but no difference was found between the PD subjects and the control group. Sienkiewicz-Jarosz and collaborators proved that PD is not associated with any major alteration in taste responses to pleasant or unpleasant stimuli (Sienkiewicz-Jarosz et al, 2005, 2013. The NTOP is a valuable method within the complex array of olfactory screening tools and it is also well received by patients.…”

Section: Discussionmentioning

confidence: 99%

New test of odor pleasantness in Parkinson�s disease

Pospichalova¹

2016

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SummaryThe New Test of Odor Pleasantness (NTOP) evaluates the hedonicity of olfactory stimulants. The aim of this study was to compare results of the NTOP, the Sniffin' Sticks test, and the Odorized Marker Test (OMT) in patients with Parkinson's disease (PD). The study sample comprised 30 PD patients (mean age 71±7.36 years) and the control group made up of 31 non-PD subjects (mean age 68±12.39 years). Sociodemographic data, medical history and tests of cognitive function were investigated. Olfaction was evaluated using the NTOP, Sniffin' Sticks test and OMT. The PD patients, compared with the control group, recorded significantly lower scores on all three tests: NTOP (p=0.00), Sniffin' Sticks (p=0.02), OMT (p=0.00). The NTOP was the test preferred by 55% of the subjects. This preference was more marked in the PD group. This study shows that the NTOP is a valuable method within the complex array of olfactory screening tools used in PD.

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6‐n‐propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease

et al. 2018

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Our results show that 6-n-propylthiouracil taster status and TAS2R38 locus are associated with PD. The 6-n-propylthiouracil test may therefore represent a novel, simple way to identify increased vulnerability to PD. Moreover, the presence of the nontasting form of TAS2R38 in PD may further substantiate that disease-associated taste disruption may represent a risk factor associated with the disease. © 2018 International Parkinson and Movement Disorder Society.

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Sweet liking in patients with Parkinson's disease

Cited by 84 publications

References 57 publications

Taste function in early stage treated and untreated Parkinson’s disease

Taste function in early stage treated and untreated Parkinson’s disease

New test of odor pleasantness in Parkinson�s disease

6‐n‐propylthiouracil taste disruption and TAS2R38 nontasting form in Parkinson's disease

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