Sweat‐gland carcinomas: prognosis related to histological type

Dissanayake, R. V. P.; Salm, R.

doi:10.1111/j.1365-2559.1980.tb02939.x

Cited by 108 publications

(64 citation statements)

References 15 publications

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“…However, it also revealed an intracystic proliferation of atypical cells without infiltration of the dermis in conformity with lesions previously reported as "syringocystadenocarcinoma papilliferum in situ" (SPCIS) [5,12,13]. There is probably a continuum from a benign SP via various grades of atypia to an infiltrating syringocystadenocarcinoma papilliferum (SPCA), but criteria for grading of these rare tumors have to our knowledge not been determined.…”

Section: Discussionsupporting

confidence: 83%

“…About 40% are associated with nevus sebaceous in the same area, some of them developing a basal cell carcinoma as well [1]. There are only few reports of transformation of an SP into an infiltrating syringocystadenocarcinoma papilliferum (SPCA) [2][3][4][5][6][7][8][9][10] and even fewer cases showing an SPCA in situ (SPCIS) [4,5,[11][12][13]. The latter tumors are characterized by a disorganized proliferation of atypical cells in the papillary structures of an SP but without tumor infiltration of the surrounding dermis.…”

Section: Introductionmentioning

confidence: 99%

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Syringocystadenocarcinoma Papilliferum In Situ: Case Report with Immunohistochemical Observations

Lindboe

Brekke

Schönhardt

et al. 2009

Scholarly Research Exchange

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A 23-year-old man was operated for a skin tumor in the right axilla. Histological examination revealed findings consistent with a syringocystadenoma papilliferum. However, most of the papillary structures showed a disorganized proliferation of atypical cells without invasive growth, that is, a syringocystadenocarcinoma papilliferum in situ. Immunohistochemistry disclosed a different staining profile between the basal cells of the papillary structures and those of the columnar and atypical cells which reacted similarly. However, the atypical cells showed a stronger and more extensive expression of S-100 protein and CD56 than the columnar epithelium and a few of them also reacted with CEA. Ki-67 staining highlighted the increased proliferative activity of the atypical cells. The best antibody for depicting the basal cells was p63. In the present case immunohistochemistry was of little help to support the diagnosis of malignant transformation since the differences between the atypical and regular columnar cells were small and of a quantitative character only.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Syringocystadenocarcinoma Papilliferum In Situ: Case Report with Immunohistochemical Observations

Lindboe

Brekke

Schönhardt

et al. 2009

Scholarly Research Exchange

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“…The natural history of MCS is variable, with some patients having an indolent course with survival of up to 17 years, while others have an accelerated course with survival of only a few weeks [3, 9]. Cell types showing high-grade undifferentiation and anaplastic changes are associated with an aggressive course, distant metastases and a decreased 5-year survival rate.…”

Section: Discussionmentioning

confidence: 99%

“…A comprehensive review of the English literature revealed nine reports describing 11 cases of MCS with lung metastasis [3, 8, 9, 10, 11, 12, 13, 14]. Data on 12 patients, 6 women and 6 men age 12–79 years at diagnosis of the primary tumor, including the current case, are presented in table 1.…”

Section: Discussionmentioning

confidence: 99%

High-Dose-Rate Endobronchial Brachytherapy in Endobronchial Metastatic Malignant Chondroid Syringoma

Solomonov

Rosenblatt

Ben‐Izhak³

et al. 2001

Respiration

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A 65-year-old man with malignant chondroid syringoma (MCS) was found to have pulmonary metastases in the form of multiple pulmonary nodules 4 years after wide excision and adjuvant radiotherapy of a primary abdominal wall tumor. Atelectasis of the lingula due to obstructive endobronchial metastasis, resistant to combination chemotherapy, led us to perform high-dose rate (HDR) endobronchial brachytherapy for the first time in this rare tumor with a favorable response. This case emphasizes the role of HDR brachytherapy as a palliative procedure in endobronchial tumors not responding to other treatment modalities, even those considered to be radioresistant.

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“…Primary cutaneous mucinous carcinoma (MC) is a neoplasm derived from the sweat glands [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25]. Since its first description in 1952, cutaneous MC has been reported to occur on the head [5, 7, 15, 23], neck [6], extremities [11, 13, 17]intertriginous areas [20]and the trunk [1].…”

Section: Introductionmentioning

confidence: 99%

Primary Mucinous Carcinoma of the Scalp

Breier

Clabian²,

Pokieser³

et al. 2000

Dermatology

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Primary cutaneous mucinous carcinoma (MC) is a rare epithelial neoplasm derived from the sweat glands. Herein, we report a case of MC located on the head. A 66-year-old woman underwent excision of a nodular tumor with a reddish brown surface on the left parietal region. Histopathology revealed a neoplasm extending from the reticular dermis into the subcutaneous fat. The tumor cell aggregates showed cribriform and solid lobules and were embedded in lakes of mucin, separated by thin, fibrous septae. Focally single neoplastic cells were arranged in an Indian-file pattern. The tumor cells displayed an eosinophilic cytoplasm, large basophilic nuclei and some discrete nuclear atypia. Vascular spaces, filled by densely packed erythrocytes between the septae, were also observed. We compared the mucinous component with the tumor cell and the stromal component by light microscopy. Analyzing the tumor by an image analysis system in Alcian-blue-stained serial sections, we found the averaged total tumor area measuring 99.7 mm². The area of the mucinous component measured 92.4 mm², that of the tumor cells 3.7 mm² and that of the stromal component 3.6 mm². The extensive checkup of the patient disclosed no evidence for a further malignant neoplasm. After excision of the tumor an adjuvant radiotherapy was performed. The patient was free of recurrence and metastatic spread of the mucinous carcinoma during a 4-year follow-up.

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Sweat‐gland carcinomas: prognosis related to histological type

Cited by 108 publications

References 15 publications

Syringocystadenocarcinoma Papilliferum In Situ: Case Report with Immunohistochemical Observations

Syringocystadenocarcinoma Papilliferum In Situ: Case Report with Immunohistochemical Observations

High-Dose-Rate Endobronchial Brachytherapy in Endobronchial Metastatic Malignant Chondroid Syringoma

Primary Mucinous Carcinoma of the Scalp

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