Sweat gland carcinoma: carcinoma: a clinico-pathological study of 83 patients

El-Domeiri, Ali A.; Brasfield, Richard D.; Huvos, Andrew G.; Strong, Elliott W.

doi:10.1097/00006534-197107000-00050

Cited by 61 publications

(111 citation statements)

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“…An eccrine tumour cell is diastase sensitive and does not retain the PAS stain. 7,9,10 Treatment choice is wide local excision with adequate tumour free margins. 7,8 The prognosis of apocrine adenocarcinoma is very poor and its prognosis all depends on size of the tumors, histological type, lymph node involvement and distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic dilemma in skin adnexa malignancy: a rare case report with review of literature

Shashirekha¹,

Krishnaprasad²,

Reddy³

et al. 2018

Int Surg J

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Apocrine malignancies are rare to occur. Axilla and the anogenital skin are the most common sites of primary tumour. Apocrine malignancy carries high risk of lymphatic and vascular spreading to lung, liver and bone. A 40 years old painter, presents with diffuse swelling and pain in the left lower limb up to left inguinal region since 5 to 6 months. With generalised lymphadenopathy. On evaluation, revealed adenocarcinoma of apocrine, skin adnexa in the extremities of the limb with extensive distant metastasis. Apart from Dermatologists other board specialty consultant should be aware of the possibility of apocrine adenocarcinoma while differentiating cutaneous tumor located in the extremities. Apocrine malignancy should be treated aggressively with wide local excision or amputation the involved part for improving the life expectancy. Since prevalence of apocrine malignancy are rare, and it is associated with increased mortality, it provoke us the field of research for discovering other modalities of treatment.

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Section: Discussionmentioning

confidence: 99%

“…This percentage, however, drops to 9% if lymph node metastasis is involved. 9,10 Various case reports mentioned that transient response to various chemotherapy agents. Bellman et al, described excellent response to systemic 5-fluorouracil chemotherapy by patient with widely metastatic apocrine gland.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic dilemma in skin adnexa malignancy: a rare case report with review of literature

Shashirekha¹,

Krishnaprasad²,

Reddy³

et al. 2018

Int Surg J

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“…4 The incidence is slightly higher in females and the highest incidence is in the sixth and seventh decades of life. 5 They lack distinctive clinical features and the histological appearences are often varied, hence diagnosis is difficult and usually late. 6 Topographically, the tumour is located at the lower limbs (32.9%), the upper extremities (28%), and the head (26%), involvement of the trunk is rare.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma of sweat gland: case report and review of literature

et al. 2015

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“…169,[272][273][274][275][276] In the primary location, carcinoma in situ of the eccrine straight ducts and of the secretory coil may be demonstrated in a fashion analogous to high-grade in-situ ductal carcinoma of the breast. 272 A further analogy with breast cancer is the presence of a parallel immunohistochemical profile including in the context of estrogen and progesterone hormone receptors.…”

Section: Histopathologymentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Sweat gland carcinoma: carcinoma: a clinico-pathological study of 83 patients

Cited by 61 publications

References 0 publications

Diagnostic dilemma in skin adnexa malignancy: a rare case report with review of literature

Diagnostic dilemma in skin adnexa malignancy: a rare case report with review of literature

Adenocarcinoma of sweat gland: case report and review of literature

Malignant adnexal neoplasms

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