SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro

Herzog, Eva; Byrne, Hugh J.; Casey, Alan; Davoren, Maria; Lenz, Anke‐Gabriele; Maier, Konrad; Duschl, Albert; Oostingh, Gertie Janneke

doi:10.1016/j.taap.2008.10.015

Cited by 93 publications

(65 citation statements)

References 67 publications

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“…In another study when A549 cells were exposed to SW-CNTs at 250-500 µg/ml for 72 h, it resulted in oxidative response and membrane damage, induced by inflammatory response [111]. Another study reported suppression of inflammatory mediators including IL-6, IL-8 and MCP-1 in vitro [112]. The effects of multi-wall carbon nanotube were also evaluated on human epidermal keratinocytes [74].…”

Section: Effects On Cell Linesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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Nanotechnology has revolutionized gene therapy, diagnostics and environmental remediation. Their bulk production, uses and disposal have posed threat to the environment. With the appearance of these nanoparticles in the environment, their toxicity assessment is an immediate concern. This review is an attempt to summarize the major techniques used in cytotoxity determination. The review also presents a detailed and elaborative discussion on the toxicity imposed by different types of nanoparticles including carbon nanotubes, gold nanoparticles, silver nanoparticles, quantum dots, fullerenes, aluminium nanoparticles, zinc nanoparticles, iron nanoparticles, titanium nanoparticles and silica nanoparticles. It discusses the in vitro and in vivo toxological effects of nanoparticles on bacteria, microalgae, zebrafish, crustacean, fish, rat, mouse, pig, guinea pig, human cell lines and human. It also discusses toxological effects on organs such as liver, kidney, spleen, sperm, neural tissues, liver lysosomes, spleen macrophages, glioblastoma cells, hematoma cells and various mammalian cell lines. It provides information about the effects of nanoparticles on the gene-expression, growth and reproduction of the organisms.

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Section: Effects On Cell Linesmentioning

confidence: 99%

In vitro and in vivo toxicity assessment of nanoparticles

2017

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“…A BET surface area of 487.15 m 2 /g was measured based on nitrogen adsorption. These particles were extensively described in a recent publication, since the exact same treatment was used for the current study, a more detailed particle characterization can be found in Herzog et al (2009). Arc discharge synthesized SWCNT were obtained from Sigma Aldrich, product number 519308 (Dublin, Ireland) and contained 50 to 70 percent SWCNT, the principle impurities being amorphous carbon, turbostratic graphite and trace amounts (< 1 wt%) of nickel and yttrium catalysts.…”

Section: Carbon Nanoparticlesmentioning

confidence: 99%

“…Inhaled particles may come into contact with this surfactant upon inhalation exposure which may lead to particle coating and modification of the surface chemistry [Wallace et al, 2007a; particles. In addition, lung surfactant can influence particle dispersion [Herzog et al, 2009] which would ultimately lead to changes in particle size distribution, agglomeration state or surface area, all factors that are believed to play an important role in the toxicity of carbon nanoparticles [Oberdorster et al, 2005a].…”

Section: Introductionmentioning

confidence: 99%

Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples

Herzog¹,

Byrne²,

Davoren³

et al. 2009

Toxicology and Applied Pharmacology

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“…In vitro toxicology studies have attempted to link specific particle sources with cellular responses. Cellular and animal exposure investigations on the toxicity and pathogenicity of carbon nanotubes have demonstrated biological interactions, including cell proliferation [2], oxidative stress [3], apoptosis [4] and inflammatory reactions [5]. However, the existing information on the lung toxicity of multi-wall carbon nanotubes (MWCNTs) are limited and remains inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells

Tsukahara

Haniu

2011

Mol Cell Biochem

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Carbon nanotubes, a promising nanomaterial with unique characteristics, have applications in a variety of fields. The cytotoxic effects of carbon nanotubes are partially due to the induction of oxidative stress; however, the detailed mechanisms of nanotube cytotoxicity and their interaction with cells remain unclear. In the present study, we focus on the acute toxicity of vapor-grown carbon fiber, HTT2800, which is one of the most highly purified multi-wall carbon nanotube (MWCNT) by high-temperature thermal treatment. We exposed human bronchial epithelial cells (BEAS-2B) to HTT2800 and measured the cellular uptake, mitochondrial function, cellular LDH release, apoptotic signaling, reactive oxygen species (ROS) generation and pro-inflammatory cytokine release. The HTT2800-exposed cells showed cellular uptake of the carbon nanotube, increased cell death, enhanced DNA damage and induced cytokine release. However, the exposed cells showed no obvious intracellular ROS generation. These cellular and molecular findings suggest that HTT2800 could cause a potentially adverse inflammatory response in BEAS-2B cells.

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SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro

Cited by 93 publications

References 67 publications

In vitro and in vivo toxicity assessment of nanoparticles

In vitro and in vivo toxicity assessment of nanoparticles

Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples

Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells

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