Swarm of magnetic nanoparticles steering in multi-bifurcation vessels under fluid flow

Hoshiar, Ali Kafash; Le, Tuan‐Anh; Valdastri, Pietro; Yoon, Jungwon

doi:10.1007/s12213-020-00127-2

Cited by 20 publications

(19 citation statements)

References 35 publications

(45 reference statements)

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“…Our previous work identified the effects of particle aggregation on nanoparticles steering [ 24 , 25 ], the results of MD simulation for the membrane crossing in the current work showed that in all crossing conditions (variations in the velocity and direction) the aggregates need a significantly higher crossing work compared to a single particle size under similar conditions. Therefore, reducing the aggregation while maintaining steerability can elevate the drug delivery to the brain.…”

Section: Results and Discussionmentioning

confidence: 61%

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Studies on Aggregated Nanoparticles Steering during Deep Brain Membrane Crossing

Hoshiar

Javan

et al. 2021

Nanomaterials

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Many central nervous system (CNS) diseases, such as Alzheimer’s disease (AD), affect the deep brain region, which hinders their effective treatment. The hippocampus, a deep brain area critical for learning and memory, is especially vulnerable to damage during early stages of AD. Magnetic drug targeting has shown high potential in delivering drugs to a targeted disease site effectively by applying a strong electromagnetic force. This study illustrates a nanotechnology-based scheme for delivering magnetic nanoparticles (MNP) to the deep brain region. First, we developed a mathematical model and a molecular dynamic simulation to analyze membrane crossing, and to study the effects of particle size, aggregation, and crossing velocities. Then, using in vitro experiments, we studied effective parameters in aggregation. We have also studied the process and environmental parameters. We have demonstrated that aggregation size can be controlled when particles are subjected to external electromagnetic fields. Our simulations and experimental studies can be used for capturing MNPs in brain, the transport of particles across the intact BBB and deep region targeting. These results are in line with previous in vivo studies and establish an effective strategy for deep brain region targeting with drug loaded MNPs through the application of an external electromagnetic field.

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Section: Results and Discussionmentioning

confidence: 61%

“…The proposed platform was studied using in vitro and in vivo experiments. Models for multiple bifurcation steering have also been developed [ 25 , 26 ], and aggregation under a rotating magnetic field has also been studied [ 27 ]. The proposed models were centered around steering of aggregates.…”

Section: Introductionmentioning

confidence: 99%

Studies on Aggregated Nanoparticles Steering during Deep Brain Membrane Crossing

Hoshiar

Javan

et al. 2021

Nanomaterials

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“…For hyperthermia treatment, the locomotion of these swarms could be exploited to deliver SPIONs to a tumor site, followed by heating. [ 18 ]…”

Section: Introductionmentioning

confidence: 99%

Closed‐Loop Temperature‐Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron‐Oxide Nanoparticles

Ahmed

Kim

Jeon

et al. 2022

Advanced Therapeutics

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Hyperthermia therapy eliminates cancer cells by heating them above physiological temperatures. Superparamagnetic iron oxide nanoparticles (SPIONs) are promising for targeted hyperthermia therapy because of their excellent heating efficiency, biocompatibility, and active magnetic navigation. When exposed to a high‐frequency alternating magnetic field (AMF), SPIONs dissipate heat to damage cancer cells. Accurate temperature control is crucial for safe and efficient hyperthermia therapy. A closed‐loop temperature controller to control the temperature and heating rate by adjusting AMF’s strength, thereby enabling controllable hyperthermia therapy. Under a low‐frequency rotating magnetic field (RMF), the SPIONs form chains which can be actively manipulated towards the target by adjusting RMF’s direction, followed by AMF exposure for hyperthermia therapy. The SPIONs are precisely manipulated in a microfluidic chip and rat brain vessels ex vivo, highlighting the potential for targeted position control. Last, in vitro, and in vivo hyperthermia treatments are performed on human prostate cancer cells (PC3) and a PC3 xenograft mouse model using the proposed temperature controller, with tracking errors under 0.5°C and significant reduction in cancer cell viability and tumor volume. The magnetic locomotion with RMF, and the controlled heating using AMF, show the feasibility of using SPIONs for targeted hyperthermia therapy.

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“…Remote magnetic actuation not only provides an unlimited operation time, but also provides the advantage of being able to miniaturize the robot because it does not require batteries. As a part of this miniaturization, magnetic particles also have been studied for various medical purpose such as targeted drug delivery, embolization, and imaging technology [ 9 , 10 , 11 , 12 , 13 ]. These advantages render magnetic robots suitable for minimally invasive medical devices that must operate for a long time inside small and narrow human organs.…”

Section: Introductionmentioning

confidence: 99%

Electrical Optimization Method Based on a Novel Arrangement of the Magnetic Navigation System with Gradient and Uniform Saddle Coils

Kim

Cho

et al. 2022

Sensors

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The magnetic navigation system (MNS) with gradient and uniform saddle coils is an effective system for manipulating various medical magnetic robots because of its compact structure and the uniformity of its magnetic field and field gradient. Since each coil of the MNS was geometrically optimized to generate strong uniform magnetic field or field gradient, it is considered that no special optimization is required for the MNS. However, its electrical characteristics can be still optimized to utilize the maximum power of a power supply unit with improved operating time and a stronger time-varying magnetic field. Furthermore, the conventional arrangement of the coils limits the maximum three-dimensional (3D) rotating magnetic field. In this paper, we propose an electrical optimization method based on a novel arrangement of the MNS. We introduce the objective functions, constraints, and design variables of the MNS considering electrical characteristics such as resistance, current density, and inductance. Then, we design an MNS using an optimization algorithm and compare it with the conventional MNS; the proposed MNS generates a magnetic field or field gradient 22% stronger on average than that of the conventional MNS with a sevenfold longer operating time limit, and the maximum three-dimensional rotating magnetic field is improved by 42%. We also demonstrate that the unclogging performance of the helical robot improves by 54% with the constructed MNS.

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Swarm of magnetic nanoparticles steering in multi-bifurcation vessels under fluid flow

Cited by 20 publications

References 35 publications

Studies on Aggregated Nanoparticles Steering during Deep Brain Membrane Crossing

Studies on Aggregated Nanoparticles Steering during Deep Brain Membrane Crossing

Closed‐Loop Temperature‐Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron‐Oxide Nanoparticles

Electrical Optimization Method Based on a Novel Arrangement of the Magnetic Navigation System with Gradient and Uniform Saddle Coils

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