Swarm and swim motilities of Salmonella enterica serovar Typhimurium and role of osmoregulated periplasmic glucans

Dharne, Mahesh; Porteen, K.; Murphy, Charles; Smith, Allen; Bhagwat, Arvind A.

doi:10.7243/2052-6180-3-3

Microbiol Discov

2015

DOI: 10.7243/2052-6180-3-3

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Swarm and swim motilities of Salmonella enterica serovar Typhimurium and role of osmoregulated periplasmic glucans

Mahesh Dharne¹,

K. Porteen²,

Charles Murphy³

et al.

Abstract: Background: Salmonella enterica serovar Typhimurium SL 1344 migrates on moist surfaces by swarming motility. S. enterica serovar Typhimurium synthesized osmoregulated periplasmic glucans (OPG) using opgGH bicistronic operon under low osmolarity conditions (<70 mMos Mol l

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Cited by 2 publications

References 35 publications

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Transcriptomic Analysis of the Swarm Motility Phenotype of Salmonella enterica Serovar Typhimurium Mutant Defective in Periplasmic Glucan Synthesis

Bhagwat¹,

Young

Smith

et al. 2017

Curr Microbiol

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Movement of food-borne pathogens on moist surfaces enables them to migrate towards more favorable niches and facilitate their survival for extended periods of time. Salmonella enterica serovar Typhimurium mutants defective in Osmoregulated periplasmic glucans (OPG) synthesis are unable to exhibit motility on moist surfaces (swarming); however, their mobility in liquid (swim motility) remains unaffected. In order to understand the role of OPG in swarm motility, transcriptomic analysis was performed using cells growing on a moist agar surface. In opgGH deletion mutant, lack of OPG significantly altered transcription of 1039 genes out of total 4712 genes (22%). Introduction of a plasmid-borne copy of opgGH into opgGH deletion mutant restored normal expression of all but 30 genes, indicating a wide-range influence of OPG on gene expression under swarm motility condition. Major pathways that were differentially expressed in opgGH mutants were motility, virulence and invasion, and genes related to the secondary messenger molecule, cyclic di-GMP. These observations provide insights and help explain the pleiotropic nature of OPG mutants such as sub-optimal virulence and competitive organ colonization in mice, biofilm formation, and sensitivity towards detergent stress.

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Transcriptomic Analysis of the Swarm Motility Phenotype of Salmonella enterica Serovar Typhimurium Mutant Defective in Periplasmic Glucan Synthesis

Bhagwat¹,

Young

Smith

et al. 2017

Curr Microbiol

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WbaP is required for swarm motility and intramacrophage multiplication of Salmonella Enteritidis spiC mutant by glucose use ability

Wang

GuiFeng

Zhang

et al. 2021

Microbiological Research

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Swarm and swim motilities of Salmonella enterica serovar Typhimurium and role of osmoregulated periplasmic glucans

Abstract: Background: Salmonella enterica serovar Typhimurium SL 1344 migrates on moist surfaces by swarming motility. S. enterica serovar Typhimurium synthesized osmoregulated periplasmic glucans (OPG) using opgGH bicistronic operon under low osmolarity conditions (<70 mMos Mol l

Cited by 2 publications

References 35 publications

Transcriptomic Analysis of the Swarm Motility Phenotype of Salmonella enterica Serovar Typhimurium Mutant Defective in Periplasmic Glucan Synthesis

Transcriptomic Analysis of the Swarm Motility Phenotype of Salmonella enterica Serovar Typhimurium Mutant Defective in Periplasmic Glucan Synthesis

WbaP is required for swarm motility and intramacrophage multiplication of Salmonella Enteritidis spiC mutant by glucose use ability

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