Suxamethonium (Succinylcholine) Chloride and Muscle Pains

Churchill‐Davidson, H. C.

doi:10.1136/bmj.1.4853.74

Cited by 128 publications

(27 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The phenomenon of postoperative myalgia was first noted in 1952: ‘The first visible effects of injections of succinylcholine were diffuse uncoordinated contractions of muscle bundles and groups … The occasional vigour of these contractions … may give rise to a feeling of muscular stiffness after consciousness has been regained’ [1]. Churchill‐Davidson [2] was the first to describe the syndrome of postoperative myalgia: ‘Succinylcholine is unsuitable for use as a muscle relaxant for out‐patient procedures, because it may be followed by severe muscle stiffness.’…”

mentioning

confidence: 99%

See 1 more Smart Citation

Succinylcholine‐associated postoperative myalgia

Wong

Chung

2000

Anaesthesia

View full text Add to dashboard Cite

SummaryThe subject of postoperative myalgia associated with the use of succinylcholine is reviewed. We discuss the mechanisms of succinylcholine-induced myalgia and the techniques available to prevent and treat the myalgia. In situations where patients are at risk of developing myalgia and succinylcholine is the neuromuscular blocker of choice, the use of a combination of techniques may prove to be a useful strategy.

show abstract

mentioning

confidence: 99%

“…The first attempt to reduce the incidence and severity of muscle pains was pretreatment with gallamine in 1954 [2]. Since then, a wide variety of regimens has been tried.…”

mentioning

confidence: 99%

Succinylcholine‐associated postoperative myalgia

Wong

Chung

2000

Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Churchill-Davidson (1954) first drew attention to muscle pains after suxamethonium administration, but this received little attention in the literature ; some writers denied that it even occurred. It has been noted that patients kept in bed for two to four days after operation rarely complain of post-operative muscle pains.…”

mentioning

confidence: 99%

Suxamethonium Chloride Administration and Postoperative Muscle Pain

Morris¹,

Dunn²

1958

Survey of Anesthesiology

View full text Add to dashboard Cite

INFECTION WITH SENDAI VIRUS MEDIBLJOURNAL 383Preliminary surveys show that antibody to Sendai virus is not uncommon in Southern England.We wish to thank Dr. F. 0. MacCallum for his active help and advice in investigating the outbreak and in preparing this paper. We are also indebted to Dr. Preston, Deputy Director, and the staff of the Regional Transfusion Centre, Oxford, for supplying specimens of blood from local donors; and to the laboratory staff at the Memorial Hospital, Cirencester, for the collection and dispatch of specimens. REFERENCES Beale, A. J., McLeod, D. L., Stackiw, W., and Rhodes, A. J. (1956) A great deal has been written in praise of suxamethonium chloride (" scoline ") as a muscle relaxant in clinical anaesthesia, stressing its freedom from sideeffects such as bronchospasm, tachycardia, and fall in blood pressure. In many ways suxamethonium is the ideal relaxant: the rapid onset of complete relaxation followed by the quick return of full muscle power has made it very popular for endotracheal intubation, orthopaedic manipulation, and short abdominal operations. The ideal conditions produced for intubation have undoubtedly reduced the incidence of minor trauma to lips, tongue, and teeth, and of sore throat. One of its principal disadvantages, that of prolonged apnoea, has received so much attention as to obscure other sideeffects which produce considerable anaesthetic morbidity.It is the purpose of this paper to call attention to muscle pain and stiffness, in some cases of great severity, following the use of suxametbonium in patients who are discharged from hospital within 48 hours of operation.Churchill-Davidson (1954) first drew attention to muscle pains after suxamethonium administration, but this received little attention in the literature ; some writers denied that it even occurred. It has been noted that patients kept in bed for two to four days after operation rarely complain of post-operative muscle pains. In the present investigations dental patients discharged the day after operation were chosen. The investigations were designed to show the incidence of post-operative muscle pain, to make an estimate of its severity, and to try to find some simple means of preventing it. TechniqueThe patients were premedicated with "omnopon" and scopolamine, or morphine and atropine, in doses appropriate to their age, weight, and physical condition. Induction was with 0.5-0.75 g. of thiopentone 5%, immediately followed by suxamethonium, 50-75 mg., and naso-tracheal intubation. Maintenance was with nitrous oxide, oxygen, and trichlorethylene. On the Nosworthy card was recorded the occupation of the patient, the dose of suxamethonium, and its speed of administration, divided into fast, medium, and slow. The resulting fasciculations were recorded as strong, moderate, and weak, and any particular muscle group strongly affected was noted. The patient's shoulders, chest, abdomen, and legs were bared in order to observe this accurately. The patients were seen the day after operation, when they were discharg...

show abstract

“…Suxamethonium is a widely accepted and useful agent for safe tracheal intubation. Unfortunately it is associated with postoperative muscle pain in 41–92% of patients [1, 9, 24], although a more recent meta‐analysis reports an incidence of between 5 and 83% [25]. Several techniques and alternative agents have been employed in an effort to reduce this complication.…”

Section: Discussionmentioning

confidence: 99%

“…The use of suxamethonium to facilitate tracheal intubation is frequently followed by troublesome postoperative myalgia and biochemical evidence of muscle damage as shown by raised serum creatine kinase [1–4]. The exact underlying pathophysiology is not clear, but the involvement of free radicals has been implicated.…”

mentioning

confidence: 99%

Continuous propofol administration for suxamethonium‐induced postoperative myalgia

et al. 1999

View full text Add to dashboard Cite

SummaryThe effect of continuous propofol administration on creatine kinase and suxamethonium-induced postoperative myalgia was evaluated in 50 patients randomised into two groups of 25 patients each. Induction of anaesthesia was identical in all patients. Anaesthesia was maintained with 66% nitrous oxide in oxygen supplemented by either isoflurane 1% or continuous propofol. Creatine kinase was measured before and after operation. Myalgia was evaluated postoperatively by a blinded observer. The median level of myalgia was reduced significantly in the continuous propofol group (p ¼ 0.011). The median creatine kinase value increased significantly in the isoflurane group (from 90 to 160 IU, p ¼ 0.001).

show abstract

Suxamethonium (Succinylcholine) Chloride and Muscle Pains

Cited by 128 publications

References 4 publications

Succinylcholine‐associated postoperative myalgia

Succinylcholine‐associated postoperative myalgia

Suxamethonium Chloride Administration and Postoperative Muscle Pain

Continuous propofol administration for suxamethonium‐induced postoperative myalgia

Contact Info

Product

Resources

About