INFECTION WITH SENDAI VIRUS MEDIBLJOURNAL 383Preliminary surveys show that antibody to Sendai virus is not uncommon in Southern England.We wish to thank Dr. F. 0. MacCallum for his active help and advice in investigating the outbreak and in preparing this paper. We are also indebted to Dr. Preston, Deputy Director, and the staff of the Regional Transfusion Centre, Oxford, for supplying specimens of blood from local donors; and to the laboratory staff at the Memorial Hospital, Cirencester, for the collection and dispatch of specimens. REFERENCES Beale, A. J., McLeod, D. L., Stackiw, W., and Rhodes, A. J. (1956) A great deal has been written in praise of suxamethonium chloride (" scoline ") as a muscle relaxant in clinical anaesthesia, stressing its freedom from sideeffects such as bronchospasm, tachycardia, and fall in blood pressure. In many ways suxamethonium is the ideal relaxant: the rapid onset of complete relaxation followed by the quick return of full muscle power has made it very popular for endotracheal intubation, orthopaedic manipulation, and short abdominal operations. The ideal conditions produced for intubation have undoubtedly reduced the incidence of minor trauma to lips, tongue, and teeth, and of sore throat. One of its principal disadvantages, that of prolonged apnoea, has received so much attention as to obscure other sideeffects which produce considerable anaesthetic morbidity.It is the purpose of this paper to call attention to muscle pain and stiffness, in some cases of great severity, following the use of suxametbonium in patients who are discharged from hospital within 48 hours of operation.Churchill-Davidson (1954) first drew attention to muscle pains after suxamethonium administration, but this received little attention in the literature ; some writers denied that it even occurred. It has been noted that patients kept in bed for two to four days after operation rarely complain of post-operative muscle pains. In the present investigations dental patients discharged the day after operation were chosen. The investigations were designed to show the incidence of post-operative muscle pain, to make an estimate of its severity, and to try to find some simple means of preventing it. TechniqueThe patients were premedicated with "omnopon" and scopolamine, or morphine and atropine, in doses appropriate to their age, weight, and physical condition. Induction was with 0.5-0.75 g. of thiopentone 5%, immediately followed by suxamethonium, 50-75 mg., and naso-tracheal intubation. Maintenance was with nitrous oxide, oxygen, and trichlorethylene. On the Nosworthy card was recorded the occupation of the patient, the dose of suxamethonium, and its speed of administration, divided into fast, medium, and slow. The resulting fasciculations were recorded as strong, moderate, and weak, and any particular muscle group strongly affected was noted. The patient's shoulders, chest, abdomen, and legs were bared in order to observe this accurately. The patients were seen the day after operation, when they were discharg...
Florida, USA, has witnessed an increased incidence of leprosy cases lacking traditional risk factors. Those trends, in addition to decreasing diagnoses in foreign-born persons, contribute to rising evidence that leprosy has become endemic in the southeastern United States. Travel to Florida should be considered when conducting leprosy contact tracing in any state.
The aim of this study was to assess attitudes to neonatal genetic screening for hereditary hemochromatosis. A total of 135 consecutive, pregnant women and their partners attending a hospital antenatal clinic in the Australian Capital Territory were given detailed written and verbal information about potential risks and benefits of neonatal genetic screening. Issues such as uncertainty of disease expression, confidentiality, genetic discrimination, and storage of genetic data were addressed. Attitudes were assessed by interview and questionnaire. There was a high level of acceptance for neonatal genetic screening in general (99%) and for hemochromatosis in particular (91.5%). There was no association of prior knowledge of hemochromatosis, family history of hemochromatosis, ethnicity, age, education, or occupation class with nonacceptance. Of the subjects, 39.5% reported feeling "a little anxious" about the prospect of screening their infants, although only 5.4% reported feeling "very anxious." Reasons given for nonacceptance of screening included inability of the child to give informed consent, insufficient evidence that diagnosis of hemochromatosis in childhood is beneficial, risk of discrimination on genetic grounds, lack of agreement between partners, and privacy issues. These data suggest that an Australian neonatal genetic screening program for hemochromatosis is likely to be accepted by this and similar groups of subjects, but there should be an opportunity for parents who object to screening to opt out of any such program.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.