Sutureless transplantation using a semi-interpenetrating polymer network bioadhesive for ocular surface reconstruction

Liu, Jia; Huang, Yongrui; Yang, Weiran; Sun, Xiaomin; Xu, Yingni; Peng, Yuehai; Song, Wenjing; Yuan, Jin; Li, Ren

doi:10.1016/j.actbio.2022.09.049

Cited by 7 publications

(5 citation statements)

References 54 publications

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“…Afterward, the interlayer structure of all membranes was visualized by staining them with a 0.2% solution of gentian violet acetic acid. [ 50 ] Finally, a stereomicroscope (Zeiss) was utilized to examine the cross‐sectional morphology of the membranes in dry, wet, and stained states. This examination aimed to evaluate the structural stability of the composite membranes in wet environments.…”

Section: Methodsmentioning

confidence: 99%

Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

Li,

Liu,

et al. 2024

Macromolecular Bioscience

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Collagen membrane with outstanding biocompatibility exhibits immense potential in the field of corneal repair and reconstruction, but the poor mechanical properties limit its clinical application. Polycaprolactone (PCL) is a biodegradable polymer that has been widely explored for application in corneal reconstruction due to its excellent mechanical properties, biocompatibility, easy processability, and flexibility. In this study, a PCL/collagen composite membrane with reinforced mechanical properties has been developed. The membrane has a strong composite structure with collagen by utilizing a porous and hydrophilic PCL scaffold, maintaining its integrity even after immersion. The suture retention and mechanical tests demonstrate that compared with the pure collagen membrane, the prepared membrane has a greater tensile strength and twice the modulus of elasticity. Further, the suture retention strength is improved by almost two times. In addition, the membrane remains fully intact on the implant bed in an in vitro corneal defect model. Moreover, the membrane could be tightly sutured to a rabbit corneal defect, progressively achieved epithelialization, and remained unchanged during observation. Overall, the PCL/collagen composite membrane is a promising candidate as a suturable corneal restoration material in clinical keratoplasty.This article is protected by copyright. All rights reserved

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Section: Methodsmentioning

confidence: 99%

Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

Li,

Liu,

et al. 2024

Macromolecular Bioscience

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“…[164] Similarly, combined oxidized HA and GelMA hydrogel (GMO bioadhesive) use in a rabbit conjunctival defect model was shown to successfully adhere to the 8 mm defect, however partial degradation was observed on day 14. [165] Nonetheless, epithelial regeneration was observed on the edges of the scaffold. [165] Modulation of the GelMA and HA ratios in an ECM-like hydrogel were shown to enhance cell viability through the modulation of corneal microenvironment.…”

Section: Hydrogel-based Ocular Adhesives For Wound Repairmentioning

confidence: 99%

“…[165] Nonetheless, epithelial regeneration was observed on the edges of the scaffold. [165] Modulation of the GelMA and HA ratios in an ECM-like hydrogel were shown to enhance cell viability through the modulation of corneal microenvironment. [166] More recently, Qian and colleagues have developed a highly transparent bioadhesive, with higher adhesion power, biocompatibility, and regenerative properties to meet the needs in ophthalmology.…”

Section: Hydrogel-based Ocular Adhesives For Wound Repairmentioning

confidence: 99%

“…methacrylate (MA)‐functionalized gelatin (GelMA), HA glycidyl methacrylate and PEG diacrylate) was shown to possess higher adhesive properties in comparison to the ReSure ® sealant, with successful occlusion of 4 mm epithelial defects [164] . Similarly, combined oxidized HA and GelMA hydrogel (GMO bioadhesive) use in a rabbit conjunctival defect model was shown to successfully adhere to the 8 mm defect, however partial degradation was observed on day 14 [165] . Nonetheless, epithelial regeneration was observed on the edges of the scaffold [165] .…”

Section: Ophthalmic Applications Of Hydrogelsmentioning

confidence: 99%

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Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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“…182 Li et al developed a bioadhesive hydrogel (GMO) used for conjunctival transplantation based on a semi-interpenetrating polymer network (SIPN) comprised of methacrylate gelatin (Gelma) and oxidized hyaluronic acid (OHA). 183 Gelma was used as a rigid support and OHA was used as the interface initiator. The obtained hydrogels can provide strong adhesion between collagen films; the maximum adhesion strength was 157 AE 17 kPa and the bursting pressure was 357 AE 29 kPa, which is 15 times higher than the human intraocular pressure (IOP).…”

Section: Tissue Repairmentioning

confidence: 99%

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Liu

2023

J. Mater. Chem. B

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Sutureless transplantation using a semi-interpenetrating polymer network bioadhesive for ocular surface reconstruction

Cited by 7 publications

References 54 publications

Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

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