Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Liu, Yongping; Xu, Xinyuan; Li, Jianshu

doi:10.1039/d3tb00251a

Cited by 8 publications

(5 citation statements)

References 230 publications

(283 reference statements)

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“…33,34 AFSR/EP cross-inked polymer network has many active groups (such as unreacted amino, epoxy, and hydroxyl), which can form chemical bonds with hydroxyl groups on the substrate surface, hydrogen bonds, and van der Waals forces. 58 Therefore, under the combined action of a variety of forces, the coating and the substrate have excellent bonding properties, which will be verified later.…”

Section: Resultsmentioning

confidence: 79%

Robust superhydrophobic silicone/epoxy functional coating with excellent chemical stability and self-cleaning ability

Huang,

Jiang,

Zhang

et al. 2023

Nanoscale

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Section: Resultsmentioning

confidence: 79%

Robust superhydrophobic silicone/epoxy functional coating with excellent chemical stability and self-cleaning ability

Huang,

Jiang,

Zhang

et al. 2023

Nanoscale

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“…With the continuous progress in science and technology, adhesive materials have developed rapidly. Various new types of adhesives are constantly emerging, finding extensive applications in industrial coatings, environmental remediation, biomedicine, pharmaceutical industry, and other fields. − Adhesives can be classified into two categories based on their chemical composition, source, and nature of materials. These categories include synthetic adhesives (such as cyanoacrylate, polyethylene glycol, polyurethane, and polyester) and natural adhesives (like cellulose protein, polysaccharides, collagen, and gelatin)…”

Section: Introductionmentioning

confidence: 99%

Tyrosinase-Modified UHMW SELP Polymers as Wet and Underwater Adhesives to Achieve Multi-interface Adhesion

Huang,

Wang,

Feng

et al. 2024

ACS Synth. Biol.

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The presence of a hydration layer in humid and underwater environments challenges adhesive–substrate interactions and prevents effective bonding, which has become a significant obstacle to the development of adhesives in the industrial and biomedical fields. In this study, ultrahigh-molecular-weight (UHMW) silk-elastin-like proteins (SELP) with 3,4-dihydroxyphenylalanine (DOPA) converted from tyrosine residues by tyrosinase exhibited excellent adhesive properties on different interfaces, such as glass, aluminum, wood, polypropylene sheets, and pigskin, under both dry and wet conditions. Additionally, by incorporating trace amounts of cross-linking agents like Fe3+, NaIO4, and tris(hydroxymethyl) phosphine (THP), the mussel-inspired adhesives maintained a stable and excellent adhesion, broadening the conditions of application. Notably, the UHMW SELP adhesive exhibited remarkable underwater adhesion properties with a shear strength of 0.83 ± 0.17 MPa on glass. It also demonstrated good adhesion to biological tissues including the kidney, liver, heart, and lungs. In vitro cytocompatibility testing using L929 cells showed minimal toxicity, highlighting its potential application in the biomedical field. The sustainable, cytocompatible, cost-effective, and highly efficient adhesive provides valuable insights for the design and development of a new protein-based underwater adhesive for medical application.

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“…Bioadhesives have the potential to replace sutures for wound closure and promote wound healing, thereby minimizing tissue damage caused by sutures. − However, the adhesive strength of bioadhesives in wet environments such as bleeding wound is inclined to significantly decrease or even vanish due to the hindrance caused by interfacial water between bioadhesives and the substrate. − The detachment of bioadhesives can lead to wound rupture and the failure of wound closure and healing. Consequently, it is necessary to develop multifunctional bioadhesives with excellent wet adhesion, rapid hemostasis, and tissue regeneration-promoting ability.…”

Section: Introductionmentioning

confidence: 99%

Facile Solvent-Free Fabrication of All-Small-Molecule Supramolecular Photothermal Bioadhesive for Sutureless Wound Closure

Yang,

Wang,

et al. 2024

ACS Biomater. Sci. Eng.

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Achieving underwater adhesion possesses a significant challenge, primarily due to the presence of interfacial water, which restricts the potential applications of adhesives. In this study, we present a straightforward and environmentally friendly one-pot approach for synthesizing a solvent-free supramolecular TPFe bioadhesive composed of thioctic acid, proanthocyanidins, and FeCl3. The bioadhesive exhibits excellent biocompatibility and photothermal antibacterial properties and demonstrates effective adhesion on various substrates in both wet and dry environments. Importantly, the adhesive strength of this bioadhesive on steel exceeds 1.2 MPa and that on porcine skin exceeds 100 kPa, which is greater than the adhesive strength of most reported bioadhesives. In addition, the bioadhesive exhibits the ability to effectively halt bleeding, close wounds promptly, and promote wound healing in the rat skin wound model. Therefore, the TPFe bioadhesive has potential as a medical bioadhesive for halting bleeding quickly and promoting wound healing in the biomedical field. This study provides a new idea for the development of bioadhesives with firm wet adhesion.

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Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Abstract: Adhesive materials are natural or synthetic polymers with the ability to adhere to the surface of luminal mucus or epithelial cells. They are widely used in the biomedical field due...

Cited by 8 publications

References 230 publications

Robust superhydrophobic silicone/epoxy functional coating with excellent chemical stability and self-cleaning ability

Robust superhydrophobic silicone/epoxy functional coating with excellent chemical stability and self-cleaning ability

Tyrosinase-Modified UHMW SELP Polymers as Wet and Underwater Adhesives to Achieve Multi-interface Adhesion

Facile Solvent-Free Fabrication of All-Small-Molecule Supramolecular Photothermal Bioadhesive for Sutureless Wound Closure

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