Sutureless closure of colonic defects with tissue adhesives: an in vivo study in the rat

Vakalopoulos, Konstantinos A.; Wu, Zhi‐Yong; Kroese, Leonard F.; Jeekel, J.; Kleinrensink, Gert-Jan; Dodou, Dimitra; Lam, King H.; Lange, Johan F.

doi:10.1016/j.amjsurg.2016.05.009

Cited by 20 publications

(16 citation statements)

References 26 publications

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“…Vakalopoulos et al have evaluated the efficacy of several biological fibrin sealants on sutureless repair of colonic defects. They have observed that Histoacryl Flex ® exhibited significantly higher collagen formation at day 10 compared to other sealants (23). In addition, a previous systematic review produced by the same study group, has revealed that application of fibrin sealants on colonic defects is promising (24).…”

Section: Discussionmentioning

confidence: 99%

The Effect of TISSEEL® on Colorectal Anastomosis Healing Process in a Diabetic Animal Experimental Model

Stergios

Frountzas

Pergialiotis

et al. 2020

In Vivo

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Background/Aim: Diabetes mellitus is an established risk factor of colorectal anastomosis failure. The purpose of the present study was to evaluate the effect of TISSEEL ® in anastomotic healing. Materials and Methods: Forty male, Sprague-Dawley rats were used. Diabetes was induced in half of them by intraperitoneal injection of Streptozotocin, 60 mg/kg. One week after the injection, animals were operated and a 1 cm segment was removed and an end-to-end hand sewn anastomosis was performed. TISSEEL ® was applied in each group (diabetic, non-diabetic) following randomization. Results: The pathology analysis revealed improved tissue remodeling in the TISSEEL ® group, both for the normoglycemic and the diabetic group. Specifically, the extent of inflammation was decreased (p<0.001), whereas fibroblast and collagen formation were improved (p=0.040 and p=0.008). Neovascularization was also improved (p=0.047). Conclusion: Application of TISSEEL ® on colorectal anastomoses improves healing in rats that suffer from severe hyperglycemia.Surgical operation is currently the definitive treatment option both for colorectal cancer and a variety of benign colorectal modalities, such as inflammatory bowel disease (IBD), inflammatory strictures, diverticulosis-diverticulitis, obstructive defecation, volvulus, fistulae etc. (1). Despite the fact that 659

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Section: Discussionmentioning

confidence: 99%

The Effect of TISSEEL® on Colorectal Anastomosis Healing Process in a Diabetic Animal Experimental Model

Stergios

Frountzas

Pergialiotis

et al. 2020

In Vivo

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“…Regarding the safety of Bioglue, our study demonstrated that the application of Bioglue on the suture line is not associated with increased mortality or dehiscence, in contrast with the study of Slieker et al[ 89 ] where the application of Bioglue on sutured colonic anastomoses in mice caused a 100% mortality rate, compared with the 40% mortality rate in the control group. Further studies are most likely required in order to assess the effects of Bioglue on anastomotic healing after direct administration into the colon, as there is only one other study assessing Bioglue’s effect in suture-less closure of colonic defects[ 90 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats

Despoudi

Mantzoros

Ioannidis

et al. 2017

WJG

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AIMTo evaluate the effect of local surgical adhesive glue (albumin/glutaraldehyde-Bioglue) on the healing of colonic anastomoses in rats.METHODSForty Albino-Wistar male rats were randomly divided into two groups, with two subgroups of ten animals each. In the control group, an end-to-end colonic anastomosis was performed after segmental resection. In the Bioglue group, the anastomosis was protected with extraluminar application of adhesive glue containing albumin and glutaraldehyde. Half of the rats were sacrificed on the fourth and the rest on the eighth postoperative day. Anastomoses were resected and macroscopically examined. Bursting pressures were calculated and histological features were graded. Other parameters of healing, such as hydroxyproline and collagenase concentrations, were evaluated. The experimental data were summarized and computed from the results of a one-way ANOVA. Fisher’s exact test was applied to compare percentages.RESULTSBursting pressures, adhesion formation, inflammatory cell infiltration, and collagen deposition were significantly higher on the fourth postoperative day in the albumin/glutaraldehyde group than in the control group. Furthermore, albumin/glutaraldehyde significantly increased adhesion formation, inflammatory cell infiltration, neoangiogenesis, and collagen deposition on the eighth postoperative day. There was no difference in fibroblast activity or hydroxyproline and collagenase concentrations.CONCLUSIONAlbumin/glutaraldehyde, when applied on colonic anastomoses, promotes their healing in rats. Therefore, the application of protective local agents in colonic anastomoses leads to better outcomes.

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“…Although fibrin glue has been used in surgical procedures for more than a decade, serving a variety of purposes, such as sutureless closure of colonic defects (19), corneal lamellar healing (20), bone repair (21,22), and reconstruction of focal cartilage defects (23), its use is not without controversy. A study by Filardo et al (24) showed improvement in postoperative scaffold stability and integrity using fibrin glue.…”

Section: Amic Microfracturing Osteochondral Defects Osteochondrosis Dmentioning

confidence: 99%

Functional Medium-Term Results After Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: A 5-Year Prospective Cohort Study

Gottschalk

Altenberger

Baumbach

et al. 2017

The Journal of Foot and Ankle Surgery

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Autologous matrix-induced chondrogenesis (AMIC) has gained popularity in the treatment of osteochondral lesions of the talus. Previous studies have presented promising short-term results for AMIC talar osteochondral lesion repair, a 1-step technique using a collagen type I/III bilayer matrix. The aim of the present study was to investigate the mid-term effects. The 5-year results of a prospective cohort study are presented. All patients underwent an open AMIC procedure for a talar osteochondral lesion. Data analysis included general demographic data, preoperative magnetic resonance imaging findings, intraoperative details, and German version of the Foot Function Index (FFI-D) scores preoperatively and at 1 and 5 years after surgery. The primary outcome variable was the longitudinal effect of the procedure, and the influence of various variables on the outcome was tested. Of 47 consecutive patients, 21 (45%) were included. Of the 21 patients, 8 were female (38%) and 13 were male (62%), with a mean age of 37 ± 15 (range 15 to 62) years and a body mass index of 26 ± 5 (range 20 to 38) kg/m. The defect size was 1.4 ± 0.9 (range 0.2 to 4.0) cm. The FFI-D decreased significantly from preoperatively to 1 year postoperatively (56 ± 18 versus 33 ± 25; p = .003), with a further, nonsignificant decrease between the 1- and 5-year follow-up examination (33 ± 25 versus 24 ± 21; p = .457). Similar results were found for the FFI-D subscales of function and pain. The body mass index and lesion size showed a positive correlation with the preoperative FFI-D overall and subscale scores. These results showed a significant improvement in pain and function after the AMIC procedure, with a significant return to sports by the 5-year follow-up point. The greatest improvement overall was seen within the first year; however, further clinical satisfaction among the patients was noticeable after 5 years.

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Sutureless closure of colonic defects with tissue adhesives: an in vivo study in the rat

Cited by 20 publications

References 26 publications

The Effect of TISSEEL® on Colorectal Anastomosis Healing Process in a Diabetic Animal Experimental Model

The Effect of TISSEEL® on Colorectal Anastomosis Healing Process in a Diabetic Animal Experimental Model

Effects of albumin/glutaraldehyde glue on healing of colonic anastomosis in rats

Functional Medium-Term Results After Autologous Matrix-Induced Chondrogenesis for Osteochondral Lesions of the Talus: A 5-Year Prospective Cohort Study

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