Suture granulomas developing after the treatment of oral squamous cell carcinoma

Yoshioka, Yukio; Nakatao, Hirotaka; Hamana, Tomoaki; Hamada, Atsuko; Taku, Keisei; Koizumi, Koichi; Toratani, Shigeaki; Okamoto, Tomoyoshi

doi:10.1016/j.ijscr.2018.07.021

Cited by 10 publications

(7 citation statements)

References 14 publications

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“…FDG-PET/CT is the most sensitive non-invasive imaging method for the detection of tumor metastasis and recurrence, but sometimes reveals false-positive results [16] . In various organs, there were several false-positive case reports of suture granuloma by FDG-PET /CT developed at surgical margin of neoplasms in the lung [ 4 , [16] , [17] , [18] , [19] , [20] , [21] ], in the oral cavity [22] , in the thyroid [ 23 , 24 ], and in the neck [ 25 , 26 ], in the stomach [ 27 , 28 ], in the colon [ 8 , 9 , 29 ] and in the ovary and testes [ 15 , 30 ]. It should be emphasized that suture granulomas can show false-positive findings on FDG-PET/CT, thus requiring differential diagnosis from recurrent tumors [26] .…”

Section: Discussionmentioning

confidence: 99%

Differentiation between suture recurrence and suture granuloma after pulmonary resection for lung cancer by diffusion-weighted magnetic resonance imaging or FDG-PET / CT

Usuda

Iwai

Yamagata

et al. 2021

Translational Oncology

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There has been no publication which supports the usefulness of DWI differentiating for suture recurrence and suture granuloma after resection for lung cancer. We presented efficacy of DWI or FDG-PET/CT for an assessment of suture lesions after resection for lung cancer. Thirteen suture recurrences and 15 suture granulomas were examined. There were 24 adenocarcinomas and 4 squamous cell carcinomas, and 26 partial resections and 2 segmentectomies. The period of time (907±907 days) between surgery and suture recurrence was not significantly longer than that (546±547 days) between surgery and suture granuloma. Diffusion detectability scores (a 5-point scale) of suture recurrences was significantly higher than that of suture granulomas. The ADC value (1.35±0.24 × 10 −3 mm 2 /sec) of suture recurrences was significantly lower than that (1.85±0.60 × 10 −3 mm 2 /sec) of suture granulomas. The SUVmax (6.1 ± 5.0) of suture recurrences was not significantly higher than that (4.2 ± 2.5) of suture granulmas. The sensitivity of 85% (11/13) with DWI was not significantly higher than 69% (9/13) with FDG-PET/CT for suture recurrences. The specificity of 73% (11/15) with DWI was not significantly higher than the 60% (9/15) with FDG-PET/CT for suture granulomas. The accuracy of 79% (22/28) with DWI was not significantly higher than that of 64% (18/28) with FDG-PET/CT for suture recurrences and granulomas. DWI can differentiate suture granuloma from suture recurrence after resection of lung cancer. DWI is more useful than FDG-PET/CT for the differentiation between suture recurrence and suture granuloma after resection for lung cancer.

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Section: Discussionmentioning

confidence: 99%

Differentiation between suture recurrence and suture granuloma after pulmonary resection for lung cancer by diffusion-weighted magnetic resonance imaging or FDG-PET / CT

Usuda

Iwai

Yamagata

et al. 2021

Translational Oncology

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“…• Mainly after ointment dressings (eg, iodine allergy) or local antibiotic ointments • Prescribe local cortisone and antihistamines 7 Late complications (weeks/months after surgery) Suture granuloma/suture dehiscence • Surgical removal of granuloma or suture • Braided or polyfilament sutures may more commonly lead to infection and granuloma formation; if applicable, reduce use in auricular region 26 • Do not remove nonresorbable sutures prior to 10 days to avoid dehiscence • Do not place cutaneous sutures under maximum tension (increased risk of dehiscence) 7…”

Section: Postoperative Painmentioning

confidence: 99%

Retrospective Analysis of Complication Rates Associated With Auricular Reconstruction After Skin Cancer Surgery

et al. 2019

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Background There is limited data regarding postoperative complications after microtia surgery or tympanoplasty; however, complication rates after pinna reconstruction following tumor resection and comorbidities associated with suboptimal outcomes have not been investigated so far. Objective To examine the incidence of postoperative complications after auricular reconstruction surgery following tumor resection and determine the association between postoperative complications and defect size, patients’ comorbidities, and reconstruction type. Methods and Materials In a retrospective case series ( n = 146, January 2014 to October 2018), we examined the surgical outcome and amount of postoperative complications following auricular surgery as well as the association with different comorbidities. SPSS 16.0 was used for statistical analyses. Results The following early postoperative complications were identified: pain (29.5%), hematoma (4.1%), flap congestion (4.8%), infection (3.4%), and flap/graft necrosis (2.7%). Late complications including cartilage step-offs, helical rim sulcus alteration, granulomas, or ear deformities occurred only in 3.6% of subjects. Reconstructions of large defects (>1 cm2) were associated with a higher incidence of early postoperative complications compared to small defects (<1 cm2) ( P < .001). Neither the presence of smoking or diabetes nor immunosuppression was significantly linked to an increased incidence of early complications. Immunosuppression, however, was associated with a higher incidence of postoperative infection ( P < .001) Conclusion The incidence of early and late postoperative complications after skin tumor resection and external ear reconstruction is low. The occurrence of postoperative infection was not linked with smoking or the presence of diabetes, but strongly associated with a state of immunosuppression, which is why a perioperative antibiotic prophylaxis in immune-compromised patients may be considered.

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“…In addition, while there are not many publications in the literature about suture-related non-healing wounds, granulomas that usually develop due to suture and manifest cancer-like findings are discussed. 8,9 Interestingly, our four patients developed excessive reaction due to prolene suture. A deeper understanding of the interaction between the material and the biological environment is essential to overcome side effects and to develop strategies and solutions in the use of these materials, which are still a major challenge in the biomedical field.…”

Section: Discussionmentioning

confidence: 77%

“…Although suture‐related chronic reactions are mostly seen after silk sutures, they do not occur with absorbable and monofilament sutures. In addition, while there are not many publications in the literature about suture‐related non‐healing wounds, granulomas that usually develop due to suture and manifest cancer‐like findings are discussed . Interestingly, our four patients developed excessive reaction due to prolene suture.…”

Section: Discussionmentioning

confidence: 80%

Non‐healing wounds: Can it take different diagnosis?

Çalış

Şengül

Güler

et al. 2019

International Wound Journal

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Wound healing is a complex cellular and biochemical process and can be affected by several systemic and local factors. In this study, we aimed to discuss the aetiologic factors of non‐healing wounds and the management of this complicated process with current information. The medical data of the patients who were admitted to our clinic due to non‐healing or chronic wounds were analysed retrospectively. A total of 27 patients were evaluated retrospectively during the 14 months of the study. The data of 6 patients who were followed up for chronic wound that developed after abdominal incisional hernia repair and pilonidal sinus surgery were not included in the study as their data could not be reached. A total of 21 patients were included in the study. Malignancy was diagnosed in two patients and granulomatous disease was found in four patients. The aetiology of the other cases included foreign body reaction, infection, and mechanical causes. Non‐healing wounds are a serious social and economic problem for patients. Further studies on the pathophysiology of various aetiologies in non‐healing wounds in both clinical settings and experimental animal models would be a useful step in treatment.

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Suture granulomas developing after the treatment of oral squamous cell carcinoma

Cited by 10 publications

References 14 publications

Differentiation between suture recurrence and suture granuloma after pulmonary resection for lung cancer by diffusion-weighted magnetic resonance imaging or FDG-PET / CT

Differentiation between suture recurrence and suture granuloma after pulmonary resection for lung cancer by diffusion-weighted magnetic resonance imaging or FDG-PET / CT

Retrospective Analysis of Complication Rates Associated With Auricular Reconstruction After Skin Cancer Surgery

Non‐healing wounds: Can it take different diagnosis?

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