Non‐healing wounds: Can it take different diagnosis?

Çalış, Hasan; Şengül, Serkan; Güler, Yılmaz; Karabulut, Zülfikar

doi:10.1111/iwj.13292

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Wounds that have healing difficulties are subcategorised into four aetiology categories: venous, pressure, diabetic and arterial insufficient ulcers. Non-healing wounds share a lack of oxygen and nutrient supply and microbial contagion, delaying the wound from healing [2]. Diabetic foot ulcerations occur in about 20% of the diabetic population, being prevalent among the chronic wound aetiologies, like venous and pressure ulcers [3].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing

et al. 2021

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Cutaneous wound healing is a vital biological process that aids skin regeneration upon injury. Wound healing failure results from persistent inflammatory conditions observed in diabetes, or autoimmune diseases like psoriasis. Chronic wounds are incurable due to factors like poor oxygenation, aberrant function of peripheral sensory nervature, inadequate nutrients and blood tissue supply. The most significant hallmark of chronic wounds is heavily aberrant immune skin function. The immune response in humans relies on a large network of signalling molecules and their interactions. Research studies have reported on the dual role of host defence peptides (HDPs), which are also often called antimicrobial peptides (AMPs). Their duality reflects their potential for acting as antibacterial peptides, and as immunodulators that assist in modulating several biological signalling pathways related to processes such as wound healing, autoimmune disease, and others. HDPs may differentially control gene regulation and alter the behaviour of epithelial and immune cells, resulting in modulation of immune responses. In this review, we shed light on the understanding and most recent advances related to molecular mechanisms and immune modulatory features of host defence peptides in human skin wound healing. Understanding their functional role in skin immunity may further inspire topical treatments for chronic wounds.

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Section: Introductionmentioning

confidence: 99%

Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing

et al. 2021

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“…attention. 1,2 However, current breakthroughs in either basic research or clinical applications of chronic nonhealing wounds have been unsatisfactory. 3 More effective therapy is urgently needed for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

“…With the increasing incidence of chronic non‐healing wounds, innovations in their effective treatments are gaining increasing attention. 1 , 2 However, current breakthroughs in either basic research or clinical applications of chronic non‐healing wounds have been unsatisfactory. 3 More effective therapy is urgently needed for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

The Z‐plasty contributes to the coalescence of a chronic non‐healing wound

Zhang

Wang

Sun

et al. 2021

International Wound Journal

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This study aimed to explore the treatment effect of Z-plasty on a non-healing wound. A total of 72 patients diagnosed with a chronic non-healing wound in Peking University Third Hospital from November 2009 to August 2019 were retrospectively analysed. Among them, 27 patients were treated with Z-plasty, and 45 patients were treated with the general method. Detailed patient information was retrieved from medical records, including age, gender, body mass index (BMI), alcohol, smoking, and comorbidities (diabetes mellitus, hypertension, heart disease). Surgical parameters included operation time and intraoperative blood loss. Wound swelling, epidermal blisters, wound edge colour, and skin temperature at 1 day after surgery were assessed to evaluate the blood supply of the wound. Surgical complications included infection, haematoma, dehiscence, and non-healing within 2 weeks postoperatively. Student t test (for continuous data) and Chi-square test (for categorical data) were conducted to determine the statistical difference. We found no significant differences in age, gender, BMI, alcohol, smoking, and comorbidities between the two groups. Z-plasty did not show any advantages in the surgical time, invasive blood loss, hospital days, and hospitalisation expenses. The incidence of abnormal wound edge colour with Zplasty was significantly lower than that with the general treatment (P < .05), and the Z-plasty enables better healing of the patient's wound (P < .05). Z-plasty promoted better recovery of chronic non-healing wounds than direct suturing.

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“…It most often develops in deep burn wounds with a prolonged healing process, usually defined as greater than 3 months. 1–3 MU reportedly affects 1% to 2% of patients with burn scars. 4…”

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confidence: 99%

“…healing process, usually defined as greater than 3 months. [1][2][3] MU reportedly affects 1% to 2% of patients with burn scars. 4 Although different malignant histologic types (eg, basal cell carcinoma and malignant melanoma) have been described, MUs have generally been considered high-risk squamous cell carcinomas (SCCs).…”

mentioning

confidence: 99%

Prognostic factors of Marjolin’s ulcers: A Meta-analysis and Systemic Review Assisted with Machine Learning Techniques

Cheng

Liu

et al. 2022

Plastic &Amp; Reconstructive Surgery

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Marjolin ulcer (MU) is a malignant tumor that commonly arises from previously injured skin, including burn injuries, traumatic wounds, scars, and other chronic nonhealing inflammatory conditions. It most often develops in deep burn wounds with a prolonged Background: Marjolin ulcers (MUs) are malignant tumors arising from previously injured skin, including burn wounds, scars, chronic ulcers, and other chronic nonhealing inflammatory conditions. They have a potentially long latent period. The authors aimed to establish the prognostic factors for recurrence, metastasis, and disease-specific death related to MU. Methods: The authors performed a comprehensive search of PubMed, Embase, and the Cochrane Library. After assessing the methodologic quality of case series, they performed a meta-analysis and systematic review. Furthermore, the authors used machine learning to predict patient survival time. Results: MUs on the upper limbs, head, and neck had a higher risk of recurrence. Contrastingly, lower grade lesions, absence of lymph node metastasis, and a tumor diameter of less than 10 cm were associated with lower recurrence risk. The risks were unrelated to age and latent period. In addition, patients without lymph node metastasis had a lower risk of developing distant metastasis. Furthermore, the risk of disease-specific death was lower in patients with a lower tumor grade, absent lymph node metastasis, small tumor diameter (<10 cm), and tumors located in regions other than the head and neck. Correlation analysis showed that the age at initial injury was negatively correlated with the latent period of MU. Conclusions: The authors found that tumor grade, tumor site, lymph node status, and tumor size are important predictors of a worse prognosis. To integrate these predictors, the authors created an equation to predict the survival time for individual patients by means of machine learning processes. Moreover, the authors found that MU developed more quickly in older individuals with injuries.

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Non‐healing wounds: Can it take different diagnosis?

Cited by 8 publications

References 10 publications

Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing

Immunomodulatory Properties of Host Defence Peptides in Skin Wound Healing

The Z‐plasty contributes to the coalescence of a chronic non‐healing wound

Prognostic factors of Marjolin’s ulcers: A Meta-analysis and Systemic Review Assisted with Machine Learning Techniques

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