Sustained UF with Gelatin Dialysis Solution during Long Dwell Dialysis Exchanges in Rats

Twardowski, Zbylut J.; Hain, H.; McGary, Terry J.; Moore, Harold L.; Keller, Richard W.

doi:10.1007/978-3-662-11784-2_45

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Cross-linked Gelatins1

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2000

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“…In acute rat experiments, 5.5 and 10% gelatin isocyanate (HaemaccelR) solutions when infused intraperitoneally yielded sustained ultrafiltration up to 6 h. The ultrafiltration volume during 6-hour dwells with 5.5% HaemaccelR solution was similar to that of 4.25% glucose, but 10% HaemaccelR induced higher ultrafiltra tion during 5-and 6-hour dwells compared to 4.25% glucose dialysis solution ( fig. 10) [48]. Since there are no studies using gelatins for longer periods, chronic toxicity is unknown.…”

Section: Cross-linked Gelatinsmentioning

confidence: 99%