Sustained relief of pain from osteosynthesis surgery of rib fracture by using biodegradable lidocaine-eluting nanofibrous membranes

Yu, Yi‐Hsun; Hsu, Yung‐Heng; Chou, Ying‐Chao; Fan, Chin-Lung; Ueng, Steve Wen–Neng; Kau, Yi-Chuan; Liu, Shih‐Jung

doi:10.1016/j.nano.2016.04.015

Cited by 12 publications

(13 citation statements)

References 36 publications

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“…Some fractures, such as clavicle shaft fractures [40,41], rib fractures [17], scapular fractures [42,43], and fibular shaft fractures, can be treated without operation due to the high success rate of the conservative treatment. In these cases, the reduction in discomfort with a good pain control strategy becomes the main goal of patient care during fracture healing.…”

Section: Discussionmentioning

confidence: 99%

“…This decreases complication rates, especially for knee and shoulder fractures, which are associated with local stiffness due to high postoperative pain [15,16]. Therefore, effective analgesia is an important component of patient care, which can improve clinical outcomes and patient satisfaction [1,17], not only for bone fracture treatment but also for other painful situations, such as surgical wound care [18].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, biodegradable polymers have also been widely used for biomedical applications. In addition to their known biocompatibility and biodegradability, these polymers are able to provide sustained and target-directed drug releases for several purposes, including cancer treatment, growth stimulation, and infection control [17,18,23,29]. Among various polymeric materials available for formulation of local release systems, poly(D,L-lactide-co-glycolide) (PLGA) is one of the most widely used because of its ability to transport drugs at high levels to target regions, where it provides a controlled released of bioactive molecules [30,31].…”

Section: Introductionmentioning

confidence: 99%

“…While lidocaine and levobupivacaine are fast and short-term anesthesia, acemetacin belongs to long-duration NSAIDs. We hypothesized that the combined delivery of acemetacin, lidocaine, and levobupivacaine to the fracture site would result in a superior and sustained pain relief of bone fractures [3,17]. After electrospraying, the particle sizes were assessed by scanning electron microscopy (SEM).…”

Section: Introductionmentioning

confidence: 99%

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Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies

Chen

Liu

Yeh

et al. 2020

IJMS

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In this study, we explored the release characteristics of analgesics, namely levobupivacaine, lidocaine, and acemetacin, from electrosprayed poly(D,L-lactide-co-glycolide) (PLGA) microparticles. The drug-loaded particles were prepared using electrospraying techniques and evaluated for their morphology, drug release kinetics, and pain relief activity. The morphology of the produced microparticles elucidated by scanning electron microscopy revealed that the optimal parameters for electrospraying were 9 kV, 1 mL/h, and 10 cm for voltage, flow rate, and travel distance, respectively. Fourier-transform infrared spectrometry indicated that the analgesics had been successfully incorporated into the PLGA microparticles. The analgesic-loaded microparticles possessed low toxicity against human fibroblasts and were able to sustainably elute levobupivacaine, lidocaine, and acemetacin in vitro. Furthermore, electrosprayed microparticles were found to release high levels of lidocaine and acemetacin (well over the minimum therapeutic concentrations) and levobupivacaine at the fracture site of rats for more than 28 days and 12 days, respectively. Analgesic-loaded microparticles demonstrated their effectiveness and sustained performance for pain relief in fracture injuries.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies

Chen

Liu

Yeh

et al. 2020

IJMS

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“…27,28 A previous study has proposed that lidocaine-embedded PLGA nanofibers can provide sustained relief of pain after the osteosynthesis surgery of rib fractures. 29 In this study, we developed lidocaine-and ketorolac-loaded PLGA nanofibers, exhibiting the capability of sustaining an elution of analgesics at the wound site, as an extended local anesthetic patch for pain relief.…”

mentioning

confidence: 99%

Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain relief for surgical wounds

Kao¹,

Lee²,

Wu³

et al. 2017

IJN

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The aim of this study was to develop and evaluate the effectiveness of biodegradable nanofibrous lidocaine/ketorolac-loaded anti-adhesion membranes to sustainably release analgesics on abdominal surgical wounds. The analgesic-eluting membranes with two polymer-to-drug ratios (6:1 and 4:1) were produced via an electrospinning technique. A high-performance liquid chromatography (HPLC) assay was employed to characterize the in vivo and in vitro release behaviors of the pharmaceuticals from the membranes. It was found that all biodegradable anti-adhesion nanofibers released effective concentrations of lidocaine and ketorolac for over 20 days post surgery. In addition, a transverse laparotomy was setup in a rat model for an in vivo assessment of activity of postoperative recovery. No tissue adhesion was observed at 2 weeks post surgery, demonstrating the potential anti-adhesion capability of the drug-eluting nanofibrous membrane. The postoperative activities were recorded for two groups of rats as follows: rats that did not have any membrane implanted (group A) and rats that had the analgesic-eluting membrane implanted (group B). Rats in group B exhibited faster recovery times than those in group A with regard to postoperative activities, confirming the pain relief effectiveness of the lidocaine- and ketorolac-loaded nanofibrous membranes. The experimental results suggested that the anti-adhesion nanofibrous membranes with sustainable elution of lidocaine and ketorolac are adequately effective and durable for the purposes of postoperative pain relief in rats.

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Introduction: Nanomedicine in the Brain

Huang

Xue

2019

Nanomedicine in Brain Diseases

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Sustained relief of pain from osteosynthesis surgery of rib fracture by using biodegradable lidocaine-eluting nanofibrous membranes

Cited by 12 publications

References 36 publications

Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies

Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies

Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain relief for surgical wounds

Introduction: Nanomedicine in the Brain

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