Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems

Yu, Cui‐Yun; Zhang, Xichen; Zhou, Fangzhou; Zhang, Xian‐Zheng; Cheng, Si‐Xue; Zhuo, Ren‐Xi

doi:10.1016/j.ijpharm.2008.01.030

Cited by 104 publications

(50 citation statements)

References 16 publications

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“…Low drug content could lead to the easier penetration of solution through microspheres and drug diffusion could be fast from the microspheres. Similar results were obtained in the literature (Zinutti et al, 1996;Nokhodchi & Tailor, 2004;Yu et al, 2008). Zinutti et al (1996) prepared ethylcellulose microspheres containing 5-FU by an oil-in-oil evaporation/ extraction method.…”

Section: Effect Of Concentration Of Fecl 3 On the 5-fu Releasesupporting

confidence: 85%

Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

Şanlı

Olukman

2013

Drug Delivery

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Ionically crosslinked microspheres of acrylamide (AAm) grafted poly (vinyl alcohol) (PVA)/ sodium alginate (NaAlg) were prepared by crosslinking with FeCl 3 and 5-fluorouracil (5-FU), which is an anticancer drug and was successfully encapsulated into the microspheres. The graft copolymer (PVA-g-PAAm) was characterized by using Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The prepared microspheres were characterized by FTIR and scanning electron microscopy (SEM). Microspheres were also characterized by particle diameter, equilibrium swelling values and release profiles. The release studies were carried out at three pH values 1.2, 6.8 and 7.4, respectively, each for 2 h. The effects of preparation conditions as PVA-g-PAAm/NaAlg ratio, drug/polymer ratio, crosslinker concentration and exposure time to FeCl 3 on the release of 5-FU were investigated for 6 h at 37 C. The highest 5-FU release was found to be as 99.57% (w/w) at the end of 6 h for PVA-g-PAAm/NaAlg ratio of 1:4 (w/w), drug/ polymer ratio of 1:8 (w/w), crosslinker concentration of 0.05 M and exposure time of 10 min. The release results were also supported by the swelling measurements of the microspheres. Release kinetics was described by Fickian and non-Fickian approaches.

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Section: Effect Of Concentration Of Fecl 3 On the 5-fu Releasesupporting

confidence: 85%

Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

Şanlı

Olukman

2013

Drug Delivery

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“…Several authors have reported a similar percentage release of various drugs from alginate/chitosan beads, demonstrating that these polymer coatings decrease drug release from microcapsules (Anal, Stevens, 2005;González-Rodríguez et al, 2002;Rajendran, Basu, 2009;Yu et al, 2008).…”

Section: In Vitro Release Profilementioning

confidence: 81%

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Reinas¹,

Hoscheid²,

Outuki³

et al. 2014

Braz. J. Pharm. Sci.

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An oleaginous fraction obtained from an alcohol extract of the fruit of Pterodon pubescens Benth. (FHPp) was microencapsulated in polymeric systems. These systems were developed using a complex coacervation method and consisted of alginate/medium-molecular-weight chitosan (F1-MC), alginate/ chitosan with greater than 75% deacetylation (F2-MC), and alginate/low-molecular-weight chitosan (F3-MC). These developed systems have the potential to both mask the taste of the extract, and to protect its constituents against possible chemical degradation. The influence of the formulation parameters and process were determined by chemical profiling and measurement of the microencapsulation efficiency of the oleaginous fraction, and by assessment of microcapsule morphology. The obtained formulations were slightly yellow, odorless, and had a pleasant taste. The average diameters of the microcapsules were 0.4679 µm (F2-MC), 0.5885 µm (F3-MC), and 0.9033 µm (F1-MC). The best formulation was F3-MC, with FHPp microencapsulation efficiency of 61.01 ± 2.00% and an in vitro release profile of 75.88 ± 0.45%; the content of vouacapans 3-4 was 99.49 ± 2.80%. The best model to describe the release kinetics for F1-MC and F3-MC was that proposed by Higuchi; however, F2-MC release displayed firstorder kinetics; the release mechanism was of the supercase II type for all formulations.Uniterms: Pterodon pubescens Benth./pharmacognosy. Sucupira. Microcapsules/preparation. Vouacapans. Alginate. Chitosan. Coacervation method. Natural polymers. Natural products.Uma fração oleaginosa obtida do extrato etanólico de frutos de Pterodon pubescens Benth (FHPp) foi microencapsulada em um sistema polimérico. Estes sistemas foram desenvolvidos utilizando o método de coacervação complexa, constituído de alginato/quitosana massa molecular média (F1-MC), alginato/ quitosana com desacetilação superior a 75% (F2-MC) e alginato/quitosana de massa molecular baixa (F3-MC). Estes sistemas desenvolvidos têm o potencial tanto de mascarar o sabor do extrato, quanto de protegê-lo de possível degradação química. A influência dos parâmetros de formulação e processo foram determinadas por caracterização química, determinação da eficiência de microencapsulação da fração oleaginosa e por avaliação morfológica da microcápsula. As formulações mostraram-se ligeiramente amareladas, inodoras e com sabor agradável. Os diâmetros médios das microcápsulas foram de 0,4679 µm (F2-MC), 0,5885 µm (F3-MC) e 0,9033 µm (F1-MC). A melhor formulação foi F3-MC, considerando-se que apresentou eficiência de encapsulação de 61,01 ± 2,00%, e perfil de liberação in vitro de 75,88 ± 0,45%; o conteúdo dos vouacapanos 3-4 foi 99,49 ± 2,80%. O melhor modelo para descrever a cinética de liberação foi o modelo proposto por Higuchi para F1-MC e F3-MC, entretanto, para F2-MC foi o modelo de primeira ordem, e o mecanismo de liberação foi do tipo super caso II para todas as formulações.Unitermos: Pterodon pubescens Benth./farmacognosia. Sucupira. Microcápsulas/preparação. Vouacapanos. Alginato. Quitosana. ...

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“…Complexation of alginate with chitosan reduces the porosity of the matrix and thus should decrease decrease the diffusion of the encapsulated material [14]. However, we found that higher allergen release from the alginate-coated microparticles actually occurred.…”

Section: Allergen Releasementioning

confidence: 64%

Development of Alginate/Chitosan Microparticles for Dust Mite Allerge

Suksamran¹,

Opanasopit²,

Rojanarata³

et al. 2011

Trop. J. Pharm Res

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Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems

Cited by 104 publications

References 16 publications

Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

Preparation of ferric ion crosslinked acrylamide grafted poly (vinyl alcohol)/sodium alginate microspheres and application in controlled release of anticancer drug 5-fluorouracil

Preparation and characterization of microcapsules of Pterodon pubescens Benth. by using natural polymers

Development of Alginate/Chitosan Microparticles for Dust Mite Allerge

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