Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Barahuie, Farahnaz; Dorniani, Dena; Saifullah, Bullo; Gothai, Sivapragasam; Hussein, Mohd Zobir; Pandurangan, Ashok Kumar; Arulselvan, Palanisamy; Norhaizan, Mohd Esa

doi:10.2147/ijn.s126245

Cited by 103 publications

(63 citation statements)

References 59 publications

(56 reference statements)

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“…The release parameters and kinetics were altered with surface modification and polymer coating of the drug-loaded nanoparticles. These results are similar to our previous results in mesoporous silica nanoparticles loaded with thymoquinone and coated with different polymer mixtures [31], as well as other studies [68]. Regarding the release of Pip from other DDSs, Shao et al reported that Pip release from a self-emulsifying DDS was 80% over 1 h [29].…”

Section: Discussionsupporting

confidence: 92%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

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Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

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Section: Discussionsupporting

confidence: 92%

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

et al. 2020

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“…Like several reported thermograms, the thermal events always begin with the elimination of absorbed water within the range of 25-122 °C (Barahuie et al 2014) and weight loss of 11.1%. Successively, the major decomposition of PA occurred at 262 °C and weight loss 67.4% (Barahuie et al 2017). Lastly, the residue decomposed at 308 °C with a weight loss of 9.1%.…”

Section: Thermal Properties Studiesmentioning

confidence: 97%

Synthesis and characterization of protocatechuic acid-loaded gadolinium-layered double hydroxide and gold nanocomposite for theranostic application

et al. 2018

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A theranostic nanocomposite was developed using anticancer agent, protocatechuic acid (PA) and magnetic resonance imaging (MRI) contrast agent gadolinium nitrate (Gd) for simultaneous delivery using layered double hydroxide (LDH) as the delivery agent. Gold nanoparticles (AuNPs) were adsorbed on the surface of the LDH, which served as a complementary contrast agent. Based on the concept of supramolecular chemistry (SPC) and multimodal delivery system (MDS), the PA and Gd guests were first intercalated into the LDH host and subsequently AuNPs were surface adsorbed as the third guest. The nanohybrid developed was named MAPGAu. The MAPGAu was exposed to various characterizations at different stages of synthesis, starting with XRD analysis, which was used to confirm the intercalation episode and surface adsorption of the guest molecules. Consequently, FESEM, Hi-TEM, XRD, ICP-OES, CHNS, FTIR and UV-Vis analyses were done on the nanohybrids. The result of XRD analysis indicated successful intercalation of the Gd and PA as well the adsorption of AuNPs. The UV-Vis release study showed 90% of the intercalated drug was released at pH 4.8, which is the pH of the cancer cells. The FESEM and TEM micrographs obtained equally confirmed the formation of MAGPAu nanocomposite, with AuNPs conspicuously deposited on the LDH surface. The cytotoxicity study of the nanohybrid also showed insignificant toxicity to normal cell lines and significant toxicity to cancer cell lines. The developed MAGPAu nanocomposite has shown prospects for future theranostic cancer treatment.

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“…Moreover, the diffusion systems rate release depends on the ratio at which the drug dissolves through a barrier which is typically a type of polymer. Diffusion systems can be broken into two subcategories, reservoir devices and matrix devices [10].…”

Section: The Barrier Principlementioning

confidence: 99%

“…Reservoir devices can coat the drug with polymers and in order for the reservoir devices to be in sustained release effects, also the polymer must not dissolve and let the drug be released through diffusion. The percentage of reservoir devices can be changed by changing the polymer and is possible be made to be zero-order release; nevertheless, drugs with higher molecular weight have difficulty diffusing through the barrier membrane [10].…”

Section: The Barrier Principlementioning

confidence: 99%

Design of Sustained Action Dosage Forms; Mini-Review

Abdellatif¹

2018

Pharm Anal Acta

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Greatest idealized per-oral sustained action products have been formulated in the form of oral dosage forms such as capsules or tablets. The characteristic trouble of preparing sustained action liquids has controlled the availability of such dosage forms. Encapsulated long-acting dosage forms have two particular benefits over capsules and tablet designs. Firstly, the inability to be disintegrated which may persist in the stomach for long periods of time, extremely suspending in the stomach and retard the absorption of maintenance dose. Secondly, the disintegration of the capsule shell in the gastric fluid releases particles that pass across the pyloric valve. Also, the release of drug by a meaningful fraction of the granules is highly possible. If a tablet fails to release drug, the entire maintenance dose is lost. This review discusses the different methods for enhancing the sustained drug action. cancer cells, such as the SSTRs, the folate receptor, and transferrin receptors. Moreover, nanoparticles coated cell-penetrating peptides and protein-transduction domains, such as oligoarginine and TAT facilitated the uptake of these nanoparticles which cannot successfully enter cancer cells [8]. This review discusses the different methods for enhancing the sustained drug action, the barrier principle, model based on diffusion, and model based on dissolution. Moreover, the review discusses the principle release from the matrix.

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Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system

Cited by 103 publications

References 59 publications

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Synthesis and characterization of protocatechuic acid-loaded gadolinium-layered double hydroxide and gold nanocomposite for theranostic application

Design of Sustained Action Dosage Forms; Mini-Review

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