Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes

Patel, Shraddha; Jammalamadaka, Uday; Sun, Lin; Tappa, Karthik; Mills, David K.

doi:10.3390/bioengineering3010001

Cited by 51 publications

(34 citation statements)

References 30 publications

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“…Its outer surface is mostly composed of SiO 2 and the inner surface of Al 2 O 3 , and, hence, those surfaces are oppositely charged [ 119 ]. The external siloxane and internal aluminol surface of halloysite is efficient as an absorbent (described above) or could be used as a carrier for drugs [ 120 , 121 , 122 , 123 ], nucleic acids [ 124 ], antibacterial agents [ 125 ], and antioxidants [ 119 , 126 , 127 , 128 , 129 , 130 ]. Therefore, halloysite is an efficient adsorbent both for cations and anions.…”

Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi. The occurrence of mycotoxins in food and feed causes negative health impacts on both humans and animals. Clay binders, yeast cell walls, or antioxidant additives are the most widely used products for mycotoxin elimination to reduce their impact. Although conventional methods are constantly improving, current research trends are looking for innovative solutions. Nanotechnology approaches seem to be a promising, effective, and low-cost way to minimize the health effects of mycotoxins. This review aims to shed light on the critical knowledge gap in mycotoxin elimination by nanotechnology. There are three main strategies: mold inhibition, mycotoxin adsorption, and reducing the toxic effect via nanoparticles. One of the most promising methods is the use of carbon-based nanomaterials. Graphene has been shown to have a huge surface and high binding capacity for mycotoxins. Attention has also been drawn to polymeric nanoparticles; they could substitute adsorbents or enclose any substance, which would improve the health status of the organism. In light of these findings, this review gives new insights into possible future research that might overcome challenges associated with nanotechnology utilization for mycotoxin elimination from agricultural products.

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Section: Nano Approaches For Mycotoxin Risk Eliminationmentioning

confidence: 99%

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

et al. 2018

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“…Due to the chemical makeup of the HNT lumen, it is capable of being doped with a diverse set of substances including antibiotics, chemotherapeutics, growth factors, RNA and DNA, and used as a vehicle for drug transportation and sustained release [20][21][22][23]. Additionally, several recent studies have demonstrated that HNTs are cytocompatible [20,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Bi-Functionalized Clay Nanotubes for Anti-Cancer Therapy

et al. 2018

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Systemic toxicity is an undesired consequence of the majority of chemotherapeutic drugs. Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. Halloysite clay nanotubes (HNTs) have shown potential as a drug delivery vehicle, and its surface can be modified and tailored as a targeted drug delivery system. In this short report, we modified the HNT surface by covalently bonding folic acid (FA) and fluorescein isothiocyanate (FITC). The modification of HNTs with folic acid imparts the potential to target tumor cells selectively. The addition of FITC offers a method for quantifying the effectiveness of the FA tagged HNTs ability to target tumor cells. We documented cell uptake of our bi-functionalized HNT (bHNT) through phase contrast and epi-fluorescent microscopy. bHNTs showed no signs of cytotoxicity up to a concentration of 150 µg/mL. The increase in cell death with increased bHNT concentration may be due to induced cytotoxicity resulting from intracellular bHNT accumulation that disrupts cellular function leading to cell death. With HNTs recognized as having the ability to serve as both a nanocontainer and nanocarrier, we envision our construct as a potential modular platform for potential use in cancer therapeutics. The HNT interior can be loaded with a variety of anti-cancer drugs (or other chemotherapeutics) and serve as a "death cargo" designed to kill cancer cells while providing feedback imaging data on drug efficacy. The surface of the HNT can be modified with gold or silver nanoparticles and used in photothermal therapy by converting light to heat inside tumors. Our HNT-based drug delivery system has the potential to provide localized and targeted therapies that limit or reduce side effects, reduce patient costs and length of hospital stays, and improve quality of life. However, further research is needed to validate the potential of this new chemotherapeutic drug delivery system.

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“…Halloysite has a molecular formula of Al 2 Si 2 O 5 (OH) 4 •nH 2 O ranging in the length from 0.2-2.0 µm. The inner and outer diameters of the halloysite nanotubes (HNTs) range from 15-50 nm and 30-50 nm respectively [31] with the difference in the inner and outer diameter imparting significant lumen space ranging from 10.7-39.0% [26]. In a recent publication by Liu and researchers [26], it has been stated that extensive research into the use of HNTs began in the 1940s and more recently it appears to be at the forefront of research partly due to the growing interest in tube-like nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Degradable Nanocomposites for Fused Filament Fabrication Applications

Healy

Waldron

Geever

et al. 2018

JMMP

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There has been a substantial increase in the use and development of plastics over the last century. However, due to ever-diminishing petroleum feedstocks and growing concern for the environment, there has been a rise in the use of eco-friendly polymers affording similar properties to that of their depleting counterparts. Poly(ε-caprolactone) is one such polymer. This present study investigates the possibility of developing a degradable nanocomposite, suitable for fused filament fabrication, utilizing hot melt extrusion technology to blend poly(ε-caprolactone), poly(ethylene) oxide and the nanoclay halloysite at loadings of two and six weight percent. The extruded blends were characterized using common polymer testing techniques. The addition of poly(ε-caprolactone) to the poly(ethylene) oxide matrix provided a plasticizing effect which was apparent with the melt flow index and melting point of the blends reducing with an increase in poly(ε-caprolactone) content. Upon reinforcing the matrix with halloysite, there was a significant improvement in mechanical properties. The addition of halloysite significantly increased Young's modulus 11% and 25% when the loading was two and six percent respectively. Furthermore, it was also possible to produce a filament with the desired properties, diameter 1.75 mm, for fused filament fabrication, with subsequent studies required to evaluate their printability.

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Sustained Release of Antibacterial Agents from Doped Halloysite Nanotubes

Cited by 51 publications

References 30 publications

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins

Bi-Functionalized Clay Nanotubes for Anti-Cancer Therapy

Degradable Nanocomposites for Fused Filament Fabrication Applications

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