Sustained Release of Amoxicillin from Ethyl Cellulose-Coated Amoxicillin/Chitosan–Cyclodextrin-Based Tablets

Abstract

Abstract. Sustained release mucoadhesive amoxicillin tablets with tolerance to acid degradation in the stomach were studied. The sustained-release tablets of amoxicillin were prepared from amoxicillin coated with ethyl cellulose (EC) and then formulated into tablets using chitosan (CS) or a mixture of CS and beta-cyclodextrin (CD) as the retard polymer. The effects of various (w/w) ratios of EC/amoxicillin, the particle sized of EC coated amoxicillin and the different (w/w) ratios of CS/CD for the retard polymer, on the amoxicillin release profile were investigated. The physicochemical properties of the EC coated amoxicillin particles and tablets were determined by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry. The result showed that the release profiles of amoxicillin were greatly improved upon coating with EC, while the inclusion of CD to the CS retardant additionally prolonged the release of the drug slightly. Overall, a sustained release of amoxicillin was achieved using amoxicillin coated with EC at a (w/w) ratio of 1:1 and a particle size of 75-100 μm. Therefore, the tablet formulation of amoxicillin may be an advantageous alternative as an orally administered sustained-release formulation for the treatment of peptic ulcers.

Hydrogels based on starch‐g‐poly(sodium‐2‐acrylamido‐2‐methyl‐1‐propane sulfonate‐co‐methacrylic acid) as controlled drug delivery systems

“…c, the spectrum of pure amoxicillin has a band at around 3470 cm −1 corresponding to the overlapped OH, NH stretching vibrations. The other characteristic peaks are at 1769 cm −1 (CO stretching of β‐lactam) and 1587 cm −1 of asymmetric stretching of craboxylate group . The band at 1008 cm −1 is attributed to the bending vibrations of CO.…”

Evaluation of Drug Release Profile from Patches Based on Styrene–Isoprene–Styrene Block Copolymer: The Effect of Block Structure and Plasticizer

“…Comparing with spectrum of pure MS, the characteristic peaks are strongly weakened in matrix-drug blends due to its low concentration in the matrix. No significant shifts in the peaks corresponding to MS or the adhesive matrix appear in the drug-polymer blends, which indicate there are no combinations of MS with the matrix (22).…”

Self-Assembled Nanocarriers Based on Modified Chitosan for Biomedical Applications: Preparation and Characterization

“…The capacity of the two macromolecular compounds to interact at the molecular level and form polyelectrolyte complexes was assessed through diffraction light scattering (DLS) and ultraviolet-visible (UV-VIS) spectrophotometry measurements. The synergistic properties of the self-assembled nanogels were highlighted by the determination of their responsiveness to environmental pH and temperature changes, as well as their antibacterial properties after being loaded with amoxicillin (Amox), a broad-spectrum antibiotic [23] with low efficacy and bioavailability.…”