Hydrogels based on starch‐g‐poly(sodium‐2‐acrylamido‐2‐methyl‐1‐propane sulfonate‐co‐methacrylic acid) as controlled drug delivery systems

Abstract

Novel hydrogel systems based on starch-g-poly(sodium-2-acrylamido-2-methyl-1-propane sulfonate-co-methacrylic acid) [starch-g-poly(AMPSNa-co-MAA)] has been prepared through graft copolymerization of AMPSNa and MAA onto starch chains. Characterization of these hydrogels is carried out using Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). Hydrogels with maximum swelling capacity have exhibited better drug absorption suggesting that they are suitable as carriers for controlled drug delivery. The capability of these hydrogels as drug delivery vehicles has been evaluated at pH values 4.0, 7.0, and 9.2 using amoxicillin trihydrate as the model drug and these hydrogels have shown more drug release in basic medium when compared to acidic or neutral media.

Synthesis and Some Physico‐Chemical Properties of Novel Starch‐g‐poly(citronellyl acrylate) Copolymers

“…As a result of the grafting process, the formation of thin polymer brush layer on a solid linear backbone of polymers is observed. These processes lead to the addition of new functional groups to polymers and thus the preparation of various structure materials which can be practically applied as stabilizers, modifiers, compatibilizers, emulsifiers, plastics, impact resistant materials, adsorbents, drug delivery systems, etc . The synthesis of various structure copolymers by applying the graft copolymerization is known.…”

“…The copolymers of carbohydrate polymers, e.g., starch, cellulose, dextran, carboxymethylcellulose, lignocellulose, alginate, chitosan, etc. and various structure vinyl monomers, e.g., styrene, methacrylates, acrylates can be synthesized . In addition, the graft copolymers of synthetic polymers such as (poly(chloroethyl vinyl ether)‐g‐polystyrene)comb‐b‐(poly(chloropyran ethoxy vinyl ether)‐g‐polyisoprene)comb, (meth)acrylate copolymer grafted with long fluorinated side chain, Nylon 6‐g‐poly(acrylic acid), polyethylene‐g‐poly(acrylic acid), polyaniline‐g‐(sulfonated polyurethane), poly(N‐vinylpyrrolidinone‐g‐styrene), etc.…”

“…These processes lead to the addition of new functional groups to polymers and thus the preparation of various structure materials which can be practically applied as stabilizers, modifiers, compatibilizers, emulsifiers, plastics, impact resistant materials, adsorbents, drug delivery systems, etc. [1][2][3][4][5][6][7][8][9] The synthesis of various structure copolymers by applying the graft copolymerization is known. The copolymers of carbohydrate polymers, e.g., starch, cellulose, dextran, carboxymethylcellulose, lignocellulose, alginate, chitosan, etc.…”

“…are also reported . Depending on the chemical structure of reagents, more hydrophobic or more hydrophilic type graft copolymers than initial polymeric materials can be prepared …”

Starch‐g‐poly(phenyl acrylate) copolymers—synthesis, characterization, and physicochemical properties

“…Due to this, such copolymers can be attractive materials for the preparation of hydrogels, adsorbents, sizers, adhesives, flocculants, matrices for chelating ion exchange resins, etc. [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. On the other hand, the grafting of hydrophobic type monomers, for example, aliphatic meth(acrylate)s or aromatic vinyl monomers, for example, styrene with polysaccharide backbone allows the synthesis of amphiphilic materials, which can be successfully utilized as a fillers, stabilizers, modifiers, matrices as well as more environmentally friendly polymers than synthetic plastics in many practical applications [15][16][17][18][19][20][21].…”