Sustained Ibuprofen Release Using Composite Poly(Lactic-co-Glycolic Acid)/Titanium Dioxide Nanotubes from Ti Implant Surface

Binary Graft Modification of Polypropylene for Anti‐Inflammatory Drug–Device Combo Products

“…PP‐g‐DMAEMA and (PP‐g‐DMAEMA)‐g‐NIPAAm with 30%, 49%, and 88% grafting showed release rate constant values of 22.52 (0.08), 17.41 (2.33), 17.20 (4.44), and 18.77 (3.56)% h −0.5 , respectively. Since plasma half‐life of ibuprofen is only 1–2 h, sustained release from a device could notably prolong the therapeutic effects . Compared with other previously reported approaches to prepare medical devices able to sustain the release of ibuprofen, the binary grafts (PP‐g‐DMAEMA)‐g‐NIPAAm showed a performance similar to that of TiO 2 nanotubes coated with poly(lactic‐co‐glycolic acid), with the advantage that no burst was observed for the binary grafts since the drug is hosted in the matrix of brushes and networks grafted onto PP.…”

Recent advances on smart TiO₂ nanotube platforms for sustainable drug delivery applications

“…This diffusion process can be defined by Fick's first law, which is influenced by various factors such as molecular size of the drugs, charge, dissolution rate and diffusion coefficient, dimensions of nanotubes, charge and surface chemistry, and interfacial interaction of drug molecules and TNT surface. [51][52][53][54][55] Depending on these conditions, different drug release profiles were obtained and different strategies have been implemented into TNT-based systems in order to provide a controlled drug release for a broad range of clinical therapies. It is known that different drug release strategies need to be considered for different therapies, thus TNT-based drug-releasing systems must be designed with flexible drug release capabilities and optimized parameters in order to fulfill the requirements of different therapies.…”

When 1 + 1 > 2: Nanostructured composites for hard tissue engineering applications

“…For example, carbon nanotube dispersion in a fumarate-based polymer yielded a material with excellent mechanical performance 126 ; however, the fate of such nanotubes in the body is uncertain, as it is difficult to predict based on the implant location whether they would degrade, migrate elsewhere or be inert. Tungsten disulfide 127 and titania 128 nanotubes have also been investigated for a potential application in polymeric composites for bone replacement. Titania nanotubes have attracted a particular attention because of the comparative ease with which they could be created as a coating on the titanium implant surface via electrochemical anodization 129 .…”