Binary Graft Modification of Polypropylene for Anti‐Inflammatory Drug–Device Combo Products

Meléndez‐Ortiz, H. Iván; Díaz‐Rodríguez, Patricia; Álvarez-Lorenzo, Carmen; Bucio, Emilio

doi:10.1002/jps.23903

Cited by 17 publications

(6 citation statements)

References 43 publications

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“…Gamma radiation (specifically 60 Co) is a technique for medical device modification, and it is used to graft or functionalize polymers on the surface of a device and to achieve drug and enzyme loading/release [12,13]. The method is based on the irradiation of the materials with gamma rays, which generates radicals on the surface that initiate the grafting polymerization process (the direct method) [14]. The advantages of this method include avoiding the use of a polymeric chemical initiator and the ability to obtain a sterilized product [15].…”

Section: Introductionmentioning

confidence: 99%

Radiation Grafting of a Polymeric Prodrug onto Silicone Rubber for Potential Medical/Surgical Procedures

et al. 2020

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Silicone rubber (SR) is a material used for medical procedures, with a common example of its application being in implants for cosmetic or plastic surgeries. It is also an essential component for the development of medical devices. SR was functionalized with the polymeric prodrug of poly(2-methacryloyloxy-benzoic acid) (poly(2MBA)) to render the analgesic anti-inflammatory drug salicylic acid by hydrolysis. The system was designed by functionalizing SR films (0.5 cm × 1 cm) with a direct grafting method, using gamma irradiation (60Co source) to induce the polymerization process. The absorbed dose (from 20 to 100 kGy) and the monomer concentration (between 0.4 and 1.5 M) were critical in controlling the surface and the bulk modifications of SR. Grafting poly(2MBA) onto SR (SR-g-2MBA) were characterized by attenuated total reflectance Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy/energy-dispersive X-ray spectrometry, fluorescence microscopy, the contact angle, and the swelling. SR-g-2MBA demonstrated the drug’s sustained and pH-dependent release in simulated physiological mediums (pH = 5.5 and 7.4). The drug’s release was quantified by high-performance liquid chromatography and confirmed by gas chromatography–mass spectrometry. Finally, cytocompatibility was demonstrated in murine fibroblast and human cervical cancer cell lines. The developed systems provide new polymeric drug release systems for medical silicone applications.

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Section: Introductionmentioning

confidence: 99%

Radiation Grafting of a Polymeric Prodrug onto Silicone Rubber for Potential Medical/Surgical Procedures

et al. 2020

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“…32,37–40,45 However, in this review, only vehicles which are specifically formulated for injection were removed from the greater localized delivery category. Hydrogels, 31,39 microparticles, 32,40 microspheres, 37,45 films/membranes, 34–36,42,43 and fibers 41,44,46 are all vehicle types that can be used to deliver drugs locally (Table 4). 31–46 These vehicle types require surgery to implant if too large to inject, unless they are used in periodontal applications, where the mucosa allows for drug penetration at the surface.…”

Section: Localized Deliverymentioning

confidence: 99%

Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

Haley

Recum

2018

Exp Biol Med (Maywood)

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Inflammatory processes are increasingly being identified at the core of many different disease states (e.g. heart disease, cancer, diabetes). As such, anti-inflammatory strategies available through drug delivery have undergone renewed interest. Due to the systemic side effects of steroidal drugs, non-steroidal anti-inflammatory drugs are often preferred for long-term treatment of inflammation in a variety of applications. While non-steroidal anti-inflammatory drugs are generally safe, there are some serious side effects that can be associated with their usage, particularly when given systemically or orally. Due to the high number of patients taking non-steroidal anti-inflammatory drugs, the reduction or elimination of these side effects, such as is possible through local drug delivery, could have a very powerful effect on patient quality of life. This review comments on a sampling of existing methods for localized or targeted delivery of non-steroidal anti-inflammatory drugs, with the goal of helping future research groups to focus on bettering methods shown to be effective and filling the gaps of knowledge in this field. Additionally, commentary is made on the field as a whole, and the standardization issues that arise from its expansiveness and diversity. Impact statement This work provides an overview of research currently being done exploring potential drug delivery device strategies for NSAIDs as an alternative to systemic delivery. Commentary on this field is made in an attempt to aid future experimental design, enabling researchers to determine the drugs and delivery vehicles which are most advantageous for them to pursue, as well as suggestions to standardize the reporting of such future research.

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“…When polymers are exposed to ionizing irradiation, trapped radicals and peroxides or hydroperoxides are formed and remain ready for initiating grafting copolymerization reactions Contreras-García et al, 2010;Ramírez-Jiménez et al, 2012). In previous works, copolymers of N-isopropyl acrylamide (NIPAAm) and N-(3-aminopropyl) methacrylamide hydrochloride (APMA) or N,N′-dimethylaminoethylmethacrylate (DMAEMA) were grafted on polypropylene (PP) films by means of a γ-ray preirradiation method in order to provide a surface layer suitable to load non-steroidal anti-inflammatory drugs (NSAIDs) and to control their release under physiological conditions (ContrerasGarcia et al, 2011;Meléndez-Ortiz et al, 2014). Cationic nitrogen groups in APMA and DMAEMA strongly interacted with diclofenac anionic groups; however, difficulties for grafting of positively charged monomers and concerns on cell compatibility prompt the search of alternative monomers that exhibit other mechanisms of interaction.…”

Section: Introductionmentioning

confidence: 99%

Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

Magaña¹,

Palomino²,

Cornejo-Bravo³

et al. 2015

Radiation Physics and Chemistry

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Binary Graft Modification of Polypropylene for Anti‐Inflammatory Drug–Device Combo Products

Cited by 17 publications

References 43 publications

Radiation Grafting of a Polymeric Prodrug onto Silicone Rubber for Potential Medical/Surgical Procedures

Radiation Grafting of a Polymeric Prodrug onto Silicone Rubber for Potential Medical/Surgical Procedures

Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

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